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1.
Definition of the problem
Full age patients with mental disorders and preserved decision-making capacity are increasingly interested in drafting advance directives. Whereas in Switzerland (as well as in Germany) advance directives are binding in principle, an advance directive is not binding and has only to be considered in case of involuntary admission due to a mental disorder. Thereby, the virtual aim of an advance directive – the anticipated self-determination – is questioned.Arguments
From an ethical perspective, patients with mental disorders have the same rights as patients with somatic diseases. Therefore, the question arises if there are good reasons for this unequal treatment. In the present contribution, four possible reasons are analyzed: (1) persons with mental disorders are “different”; (2) protection from self-harm; (3) often not present end-of-life context; (4) reduced bindingness as the more appropriate standard in general.Conclusion
The authors come to the conclusion that patients with mental disorders are often capable of composing a valid advance directive, and just as any other human being, they have a principal and binding right for self-determination, even though they are particularly vulnerable in crisis situations.2.
3.
This Extended Technical Note shows that the final accuracy level of reverse engineered surfaces depends on scanning distance and scanning angle of the laser beam, hence it also depends on the morphology of the scanned objects. On scanning strongly curved objects, such as the ones with free form surfaces, the distance and impact angle of the laser beam are changing continuously during the scanning process. On the basis of these, two critical parameters are specified for the design model, which make it possible to predict these two factors in advance, depending on the morphology of the scanned object. First, a mathematical-statistical design model of the scanning process is generated, which relies on ANOVA (analysis of variance) and DOE (design of experiments). In the next step, a fitness function is optimized by the genetic algorithm (GA) program. This optimization improves the accuracy of the final scanned surfaces, in terms of the minimum standard deviation values of reverse engineered 3D surface model. The proposed approach was confirmed in a case study, which is presented at the end of this Technical Note. 相似文献
4.
Veronika Bilanovi
ov Nikola Rýdza Lilla Koczka Martin Hess Elena Feraru Jií Friml Tomasz Nodzyski 《International journal of molecular sciences》2022,23(11)
Much of plant development depends on cell-to-cell redistribution of the plant hormone auxin, which is facilitated by the plasma membrane (PM) localized PIN FORMED (PIN) proteins. Auxin export activity, developmental roles, subcellular trafficking, and polarity of PINs have been well studied, but their structure remains elusive besides a rough outline that they contain two groups of 5 alpha-helices connected by a large hydrophilic loop (HL). Here, we focus on the PIN1 HL as we could produce it in sufficient quantities for biochemical investigations to provide insights into its secondary structure. Circular dichroism (CD) studies revealed its nature as an intrinsically disordered protein (IDP), manifested by the increase of structure content upon thermal melting. Consistent with IDPs serving as interaction platforms, PIN1 loops homodimerize. PIN1 HL cytoplasmic overexpression in Arabidopsis disrupts early endocytic trafficking of PIN1 and PIN2 and causes defects in the cotyledon vasculature formation. In summary, we demonstrate that PIN1 HL has an intrinsically disordered nature, which must be considered to gain further structural insights. Some secondary structures may form transiently during pairing with known and yet-to-be-discovered interactors. 相似文献
5.
The idea of non-hierarchical production networks consisting of autonomous enterprises has been present in scientific community for more than 20 years. Although some global corporations are using their own production networks across continents, they are not similar to the original idea of non-hierarchical production networks in many aspects. It seems that this idea waited for production systems to acquire proper information and communications technology (ICT) or new industrial platforms, like Industry 4.0. The result is a new type of production network called Cyber-Physical Production Network (CPPN). The CPPN is, from ICT point of view, ready to act as non-hierarchical production networks consisting of autonomous production systems with many automated processes. One of the most important processes of the CPPN is a selection of optimal partners (enterprises) to be part of a new virtual enterprise, created inside production network. An optimisation problem emerges in this process, and it is called Partner Selection Problem (PSP). It is non-polynomial-hard combinatorial problem. Since metaheuristic algorithms are well-proven in solving that kind of problem, a specially designed metaheuristic algorithm derived from ant colony optimisation and named the HUMANT (HUManoid ANT) algorithm is used in this paper. It is multi-objective optimisation algorithm that successfully solves different instances of PSP with two, three, four or more objectives. 相似文献
6.
Silk electrogelation involves the transition of an aqueous silk fibroin solution to a gel state (E-gel) in the presence of an electric current. The process is based on local pH changes as a result of water electrolysis - generating H(+) and OH(-) ions at the (+) and (-) electrodes, respectively. Silk fibroin has a pI=4.2 and when local pH相似文献
7.
In this article, the role of the restoring stiffness, as one of the basic parameters in ship hydroelastic analysis, is brought
out. It is formulated using the variational principle and the method of virtual displacements. It is shown that asymmetry
of the restoring stiffness is a physical reality. Moreover, it is confirmed that modal variation, still disputed in the relevant
literature, has to be taken into account to satisfy the ship’s stability. Consistent stiffness is formulated here by regarding
stiffness definition as relation between forces and displacements. Hybrid stiffness known from the literature is wrong since
some terms are specified as relation between forces and displacement gradient. Influence of the consistent and symmetrized
stiffness matrix, and the hybrid one, on dynamic response is illustrated for a prismatic pontoon and a large container ship.
It is found that the latter two matrices do not assure convergence of transfer functions of sectional forces to zero value
as the wave frequency approaches zero. The rigid body and elastic responses are compared, and pertinent conclusions are drawn.
It is also shown that it is not necessary to use the unified geometric and restoring stiffness for ordinary hydroelastic analysis
of ship structures. The consistent formulation of the restoring stiffness matrix will be useful for extending linear potential
theory hydrodynamic codes for rigid body analysis to deformable bodies. 相似文献
8.
9.
Jing-jing Wang Zhen‐hong Jia Xi‐zhong Qin Jie Yang Nikola Kasabov 《International journal of imaging systems and technology》2015,25(1):7-14
In order to solve the problem of noise amplification, low contrast and image distortion in the process of medical image enhancement, a new algorithm is proposed which combines NSCT (nonsubsampled contourlet transform) and improved fuzzy contrast. The image is decomposed by NSCT. Firstly, linear enhancement method is used in low frequency coefficients; secondly the improved adaptive threshold function is used to deal with the high frequency coefficients. Finally, the improved fuzzy contrast is used to enhance the global contrast and the Laplace operator is used to enhance the details of the medical images. Experimental results show that the proposed algorithm can improve the image visual effects, remove the noise and enhance the details of medical images. © 2015 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 25, 7–14, 2015 相似文献