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1.
Karina Polak Beata Bergler-Czop Micha Szczepanek Kamila Wojciechowska Aleksandra Frtczak Norbert Kiss 《International journal of molecular sciences》2021,22(9)
Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Psoriasis Microbiome Index were developed in order to distinguish between psoriatic and healthy individuals. The “leaky gut syndrome” and bacterial translocation is considered by some authors as a triggering factor for the onset of the disease, as it promotes chronic systemic inflammation. The alterations were also found to resemble those in inflammatory bowel diseases, obesity and certain cardiovascular diseases. Microbiota dysbiosis, depletion in SCFAs production, increased amount of produced TMAO, dysregulation of the pathways affecting the balance between lymphocytes populations seem to be the most significant findings concerning gut physiology in psoriatic patients. The gut microbiota may serve as a potential response-to-treatment biomarker in certain cases of biological treatment. Oral probiotics administration as well as fecal microbial transplantation were most reported in bringing health benefits to psoriatic patients. However, the issue of psoriatic bacterial gut composition, its role and healing potential needs further investigation. Here we reviewed the literature on the current state of the relationship between psoriasis and gut microbiome. 相似文献
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Marcus Heinze Sandra Starke Marcel Händler Hartmut Komber Marco Drache Norbert Moszner Brigitte Voit Doris Pospiech 《应用聚合物科学杂志》2019,136(48):48256
We demonstrate in this study that the combination of modern inline monitoring methods [here: inline nuclear magnetic resonance (NMR)] with simulations gains more exact and profound kinetic results than previously used methods like linearization without that combination. The 1H-NMR spectroscopic data (more than 100 data points) are used to construct the copolymerization diagram. The reactivity ratios are obtained applying the van Herks nonlinear least square method. The examination of the radical copolymerization of 2-hydroxyethyl methacrylate (HEMA) with (2-{[2-(ethoxycarbonyl)prop-2-en-1-yl]oxy}ethyl) phosphonic acid (ECPPA) as important adhesive monomer used in dentistry yields reactivity ratios of rHEMA = 1.83; rECPPA = 0.42. The copolymerization diagram reflects nonideal, non-azeotropic copolymerization. The sequence distribution of the obtained by Monte Carlo simulation indicates the generation of statistical copolymers. As an important finding, it is demonstrated that the repeating units responsible for etching and adhesion are arranged over the whole polymer chain, which is necessary to achieve proper functionality. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 48256. 相似文献
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R Zahn A Vogt K Seidl S Schuster H Gülker KW Heinrich M Gottwik K Neuhaus J Senges 《Canadian Metallurgical Quarterly》1997,86(9):712-721
Balloon angioplasty as the treatment of first choice in the setting of an acute myocardial infarction (AMI) is gaining widespread acceptance because of favourable results from specialised centres concerning high patency rates and low mortality. This study reports the results of angioplasty for AMI at large community hospitals during 1992-1995. 4625 procedures were performed at 68 centres of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhaus?rzte (ALKK). The age of the patients was 60.8 +/- 11.3 years, with 75.1% men. The infarct related artery was the left anterior descendent in 43%, the right coronary artery in 37%, the circumflex artery in 16%, a bypass graft in 2.3% and the left main stem in 1.4% of patients. The success rate (residual stenosis < 50%) of the intervention was 86%. There was a wide range of procedures per centre, with a median of 40 AMI angioplasties per year and centre. The amount of angioplasties for AMI in relation to all angioplasties performed during this period rose from 5.2% in 1992 to 5.9% in 1995 (p = 0.01). Local complications at the puncture site occurred in 3.2%, with the need for a surgical intervention in 1.1% of patients. In 273 (5.9%) of the patients a second angioplasty was performed during the hospital stay. Aortocoronary bypass surgery was performed in 3% of the patients. Hospital mortality was 9.5% (438/4625 patients). The mortality rate remained constant during the years investigated (1992: 10.6%; 1993: 8.6%; 1994: 9.7%; 1995: 9.8%; p = ns). Higher mortality was observed in older patients, patients with multiple vessel disease, the left anterior descending artery or a bypass graft as infarct related artery as well as in patients with failed reperfusion (residual stenoses > 50%). Hospitals with a case load of more than 40 angioplasties for AMI per year showed a lower mortality as compared to the others. In clinical practice at large community hospitals results of angioplasty for AMI concerning mortality, complications and technical success rate are comparable to those of highly specialised centres. The absolute numbers of angioplasties for AMI increased constantly over the years. 相似文献
8.
Norbert Fischer Siegfried Nitz und Friedrich Drawert 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1987,185(3):195-201
Zusammenfassung In grünem (Taiwan Gunpowder) und schwarzem (Ceylon high OP) Tee sind beträchtliche Mengen an Aromastoffen in glykosidischer Bindung vorhanden; ihr Anteil ist sogar höher als der an freien Aromastoffen. Hauptkomponenten sind in beiden Teesorten cis-3-Hexen-1-ol, Benzylalkohol und 2-Phenylethanol in gebundener Form, dazu im Schwarztee Linalool und im grünen Tee Geraniol. Die unterschiedlichen Anteile dieser beiden Terpenalkohole spiegeln die unterschiedlichen Tee-Varietäten wieder, denen die untersuchten Teesorten angehören: der Ceylon-Tee ist der Varietätassamica zuzuordnen, der Tee aus Taiwan der Varietätsinensis. Die Zusammensetzung der aus gebundenen Formen freisetzbaren Aromastoffe war ähnlich komplex wie die der freien Aromastoffe, wobei die Unterschiede zwischen den beiden Teesorten auf den verschiedenen Herstellungsverfahren beruhen. Das Auftreten gebundener Formen solcher Aromastoffe, die nicht originär vorhanden sind, sondern erst während der Welk- oder der Fermentationsphase gebildet werden, impliziert das Vorhandensein glykosidierender Aktivitäten im Teeblatt noch in relativ späten Stadien der Schwarzteeherstellung. Die Untersuchung der gebundenen Anteile an Aromastoffen trägt neben der Analyse der freien Aromastoffe wesentlich zum Verständnis der Reaktionen im Teeblatt wahrend der verschiedenen Produktionsstadien bei.
Auszug aus der Dissertation von N. Fischer, Technische Universitat München 1986
1. Mitteilung Chem Mikrobiol Technol Lebensm 9:87 (1985) 相似文献
Bound flavour compounds in plants 2. Part. Free and bound flavour compounds in green and black tea
Summary Green and black tea contains considerable amounts of flavour compounds which are present in glycosidic bonds, their portion being even higher than that of free flavour compounds. The main components in both of these tea varieties are 3-hexene-1-ol, benzylalcohol and 2-phenylethanol, which are present in the bound forms, and additionally linalool in black tea and geraniol in green tea. The different amounts of these terpene alcohols reflect the different varieties the teas under investigation belong to: the Ceylon tea belongs to the variety assamica, and the Taiwan tea to the variety sinensis. The composition of the flavour compounds liberated from bound forms had a similar complexity to that of the free flavour compounds, the difference being based upon the different production procedures. The occurrence of bound forms of such components that are not originally present but are produced during the withering or fermentation stage implies that glycosidating activities are still present in the tea leaf, even in a relatively late stage of the black tea production process. The investigation of the bound parts of flavour compounds delivers a valuable contribution to a better understanding of the reactions occurring in the tea leaf during the different stages of tea production.
Auszug aus der Dissertation von N. Fischer, Technische Universitat München 1986
1. Mitteilung Chem Mikrobiol Technol Lebensm 9:87 (1985) 相似文献
9.
Abe Schwartz Lili Wang Edward Early Adolfas Gaigalas Yu-zhong Zhang Gerald E. Marti Robert F. Vogt 《Journal of research of the National Institute of Standards and Technology》2002,107(1):83-91
The quantitation of fluorescence radiance may at first suggest the need to obtain the number of fluorophore that are responsible for the measured fluorescence radiance. This goal is beset by many difficulties since the fluorescence radiance depends on three parameters 1) the probability of absorbing a photon (molar extinction), 2) the number of fluorophores, and 3) the probability of radiative decay of the excited state (quantum yield). If we use the same fluorophore in the reference solution and the analyte then, to a good approximation, the molar extinction drops out from the comparison of fluorescence radiance and we are left with the comparison of fluorescence yield which is defined as the product of fluorophore concentration and the molecular quantum yield. The equality of fluorescence yields from two solutions leads to the notion of equivalent number of fluorophores in the two solutions that is the basis for assignment of MESF (Molecules of Equivalent Soluble Fluorophore) values. We discuss how MESF values are assigned to labeled microbeads and by extension to labeled antibodies, and how these assignments can lead to the estimate of the number of bound antibodies in flow cytometer measurements. 相似文献
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Yan T Wong Norbert Dommel Philip Preston Luke E Hallum Torsten Lehmann Nigel H Lovell Gregg J Suaning 《IEEE transactions on neural systems and rehabilitation engineering》2007,15(3):425-434
A neurostimulator application-specific integrated circuit (ASIC) with scalable circuitry that can stimulate 14 channels, has been developed for an epi-retinal vision prosthesis. This ASIC was designed to allow seven identical units to be connected to control up to 98 channels, with the ability to stimulate 14 electrodes simultaneously. The neurostimulator forms part of a vision prosthesis, designed to restore vision to patients who have lost their sight due to retinal diseases such as retinitis pigmentosa and macular degeneration. For charge balance, the neurostimulator was designed to stimulate with current sources and sinks operating together, and with the ability to drive a hexagonal mosaic of electrodes to reduce the electrical crosstalk that occurs when multiple bipolar stimulation sites are active simultaneously. A hexagonal mosaic of electrodes surrounds each stimulation site and has been shown to effectively isolate each site, increasing the ability to inject localized independent charge into multiple regions simultaneously. 相似文献