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Kruk Menno R.; Halász József; Meelis Wout; Haller József 《Canadian Metallurgical Quarterly》2004,118(5):1062
Aggressive behavior induces an adrenocortical stress response, and sudden stressors often precipitate violent behavior. Experiments in rats revealed a fast, mutual, positive feedback between the adrenocortical stress response and a brain mechanism controlling aggression. Stimulation of the aggressive area in the hypothalamus rapidly activated the adrenocortical response, even in the absence of an opponent and fighting. Hypothalamic aggression, in turn, was rapidly facilitated by a corticosterone injection in rats in which the natural adrenocortical stress response was prevented by adrenalectomy. The rapidity of both effects points to a fast, mutual, positive feedback of the controlling mechanisms within the time frame of a single conflict. Such a mutual facilitation may contribute to the precipitation and escalation of violent behavior under stressful conditions. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Walter Binder Ion Constantinescu Boi Faltings Klaus Haller Can Türker 《Autonomous Agents and Multi-Agent Systems》2006,12(2):219-237
This article presents an architecture to automatically create ad-hoc processes for complex value-added services and to execute
them in a reliable way. The uniqueness of ad-hoc processes is to support users not only in standardized situations like traditional
workflows do, but also in unique non-recurring situations. Based on user requirements, a service composition engine generates
such ad-hoc processes, which integrate individual services in order to provide the desired functionality. Our infrastructure
executes ad-hoc processes by transactional agents in a peer-to-peer style. The process execution is thereby performed under
transactional guarantees. Moreover, the service composition engine is used to re-plan in the case of execution failures.
The work presented in this article was supported by the Swiss National Science Foundation as part of the project MAGIC (FNRS-68155),
as well as by the Swiss National Funding Agency OFES as part of the European projects KnowledgeWeb (FP6-507482) and DIP (FP6-507483).
Authors in alphabetic order 相似文献
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W. S. Holland P. A. R. Ade M. J. Griffin I. D. Hepburn D. G. Vickers C. R. Cunningham P. R. Hastings W. K. Gear W. D. Duncan T. E. C. Baillie E. E. Haller J. W. Beeman 《Journal of Infrared, Millimeter and Terahertz Waves》1996,17(4):669-692
We describe the design and construction of bolometric detectors for SCUBA - the Submillimetre Common-User Bolometer Array for the James Clerk Maxwell Telescope in Hawaii. The instrument contains 131 individual detectors, in two arrays, optimized for the submillimetre atmospheric transmission windows. The detectors are cooled by dilution refrigeration to a temperature of 100 mK, so that the receiver performance will be limited by photon noise from the sky and telescope background in all wavebands. A future paper will describe the performance of the detectors with reference to typical data obtained during the laboratory commissioning period. 相似文献
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CG Moertel TR Fleming JS Macdonald DG Haller JA Laurie 《Canadian Metallurgical Quarterly》1993,11(12):2386-2390
PURPOSE: To determine the frequency and nature of hepatic toxicity associated with fluorouracil (5-FU) plus levamisole adjuvant therapy. PATIENTS AND METHODS: All patients had resection of stage II or stage III colon cancer and were randomized to receive observation only, levamisole alone, or 5-FU plus levamisole. Serial liver function studies were documented in 1,025 patients who did not develop recurrence during the year of therapy. RESULTS: One hundred forty-nine (39.6%) of 376 patients treated with 5-FU plus levamisole showed laboratory abnormalities consistent with hepatic toxicity, compared with 16.3% of 251 patients treated with levamisole alone and 16.1% of 398 untreated controls. Most common was elevation of alkaline phosphatase, frequently accompanied by elevations of transaminase or serum bilirubin. Characteristically, these changes were mild, not associated with symptoms, and resolved when therapy was stopped. In some instances, they were associated with elevated carcinoembryonic antigen (CEA) tests or with fatty liver seen on computed tomographic (CT) scan or liver biopsy. CONCLUSION: Mild and reversible hepatotoxicity is a common consequence of 5-FU plus levamisole adjuvant therapy, but this is only rarely symptomatic. However, the oncologist should be alert to this phenomenon, since the associated laboratory and imaging findings may simulate those associated with hepatic metastasis. 相似文献
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J Haller I Pintér I Gyertyán E Békási GB Makara 《Canadian Metallurgical Quarterly》1996,4(1-2):111-113
We investigated a family with optic atrophy which occurred in childhood or early adulthood plus late-onset cerebellar ataxia. The magnetic resonance imaging in the proband revealed cerebellar atrophy. The proband and her brother were homoplasmic for the most common mitochondrial DNA (mtDNA) 11778 mutation associated with Leber's hereditary optic neuropathy (LHON). This study showed further evidence that central nervous system lesions can occur in cases of LHON mtDNA mutation. 相似文献
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J Haller I Abrahám D Zelena G Juhász GB Makara MR Kruk 《Canadian Metallurgical Quarterly》1998,9(5-6):469-475
Early investigators of brain stimulation-evoked complex behaviours (attack, escape, feeding, self-grooming, sexual behaviour) reported that experience may affect the behavioural outcome of brain stimulation. This intriguing example of functional neuronal plasticity was later totally neglected. The present experiment investigated the behavioural outcome of in vivo microdialysis perfusion of the glutamate agonist kainate and/or the GABAA antagonist bicuculline into the hypothalamic attack area (HAA) of (1) animals naive to dyadic encounters; (2) animals with a recent aggressive experience (the probe being implanted 6-24 h after the last of a series of dyadic encounters); and (3) animals with an earlier aggressive experience (probe being implanted 2 weeks after the last aggressive experience). On the experimental day, rats received two 5-min infusions during a dyadic encounter lasting 35 min with an unknown opponent. Flow rate was 1.5-2 microliters/min, drug concentrations were 1.8 x 10(-5) and 1.5 x 10(-5) M for kainate and bicuculline, respectively. Behaviour was analysed before, during and after perfusions. Only the combined kainate + bicuculline treatment had significant effects on behaviour at the doses studied. A significant increase in aggressive behaviour was elicited only in animals with a recent aggressive experience, while naive animals and with an earlier experience responded to the treatments by grooming. These results appear to support early observations indicating that one important aspect of brain stimulation effects is previous experience. 相似文献