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1.
2.
Dina Had?iosmanovi? Damiano Bolzoni Pieter H. Hartel 《International Journal of Information Security》2012,11(4):231-251
SCADA (supervisory control and data acquisition) systems are used for controlling and monitoring industrial processes. We propose a methodology to systematically identify potential process-related threats in SCADA. Process-related threats take place when an attacker gains user access rights and performs actions, which look legitimate, but which are intended to disrupt the SCADA process. To detect such threats, we propose a semi-automated approach of log processing. We conduct experiments on a real-life water treatment facility. A preliminary case study suggests that our approach is effective in detecting anomalous events that might alter the regular process workflow. 相似文献
3.
Lejla Medzikovic Hylja Heese Pieter B. van Loenen Cindy P. A. A. van Roomen Ingeborg B. Hooijkaas Vincent M. Christoffels Esther E. Creemers Carlie J. M. de Vries Vivian de Waard 《International journal of molecular sciences》2021,22(4)
Fibrosis is a hallmark of adverse cardiac remodeling, which promotes heart failure, but it is also an essential repair mechanism to prevent cardiac rupture, signifying the importance of appropriate regulation of this process. In the remodeling heart, cardiac fibroblasts (CFs) differentiate into myofibroblasts (MyoFB), which are the key mediators of the fibrotic response. Additionally, cardiomyocytes are involved by providing pro-fibrotic cues. Nuclear receptor Nur77 is known to reduce cardiac hypertrophy and associated fibrosis; however, the exact function of Nur77 in the fibrotic response is yet unknown. Here, we show that Nur77-deficient mice exhibit severe myocardial wall thinning, rupture and reduced collagen fiber density after myocardial infarction and chronic isoproterenol (ISO) infusion. Upon Nur77 knockdown in cultured rat CFs, expression of MyoFB markers and extracellular matrix proteins is reduced after stimulation with ISO or transforming growth factor–β (TGF-β). Accordingly, Nur77-depleted CFs produce less collagen and exhibit diminished proliferation and wound closure capacity. Interestingly, Nur77 knockdown in neonatal rat cardiomyocytes results in increased paracrine induction of MyoFB differentiation, which was blocked by TGF-β receptor antagonism. Taken together, Nur77-mediated regulation involves CF-intrinsic promotion of CF-to-MyoFB transition and inhibition of cardiomyocyte-driven paracrine TGF-β-mediated MyoFB differentiation. As such, Nur77 provides distinct, cell-specific regulation of cardiac fibrosis. 相似文献
4.
Pieter Coenen Margriet Formanoy Marjolein Douwes Tim Bosch Heleen de Kraker 《Applied ergonomics》2014
Exposure to mechanical vibrations at work (e.g., due to handling powered tools) is a potential occupational risk as it may cause upper extremity complaints. However, reliable and valid assessment methods for vibration exposure at work are lacking. Measuring hand-arm vibration objectively is often difficult and expensive, while often used information provided by manufacturers lacks detail. Therefore, a subjective hand-arm vibration assessment method was tested on validity and inter-observer reliability. 相似文献
5.
A wireless sensor network (WSN) commonly whilst a body sensor network (BSN) must be secured with requires lower level security for public information gathering, strong authenticity to protect personal health information. In this paper, some practical problems with the message authentication codes (MACs), which were proposed in the popular security architectures for WSNs, are reconsidered. The analysis shows that the recommended MACs for WSNs, e.g., CBC- MAC (TinySec), OCB-MAC (MiniSec), and XCBC-MAC (SenSee), might not be exactly suitable for BSNs. Particularly an existential forgery attack is elaborated on XCBC-MAC. Considering the hardware limitations of BSNs, we propose a new family of tunable lightweight MAC based on the PRESENT block cipher. The first scheme, which is named TukP, is a new lightweight MAC with 64-bit output range. The second scheme, which is named TuLP-128, is a 128-bit variant which provides a higher resistance against internal collisions. Compared with the existing schemes, our lightweight MACs are both time and resource efficient on hardware-constrained devices. 相似文献
6.
Zhong Zhiyuan Schneiderbauer Stefan Dijkstra Pieter J. Westerhausen Matthias Feijen Jan 《Polymer Bulletin》2003,50(3):175-182
Summary
Single-site calcium initiators containing chelating tmhd
(H-tmhd = 2,2,6,6-tetramethylheptane-33-dione) ligands
[(THF)Ca(tmhd)]2[-N(SiMe3)2](-tmhd)
(2) and
[(THF)Ca(tmhd)]2[-OCH(Me)Ph](-tmhd)
(3) have been synthesized and
applied for the ring-opening polymerization of L-lactide and
-caprolactone. Both 2 and
3 were highly reactive and
promoted a fast polymerization of L-lactide and -caprolactone
to high monomer conversions under mild conditions (THF as a
solvent, room temperature). More importantly, results showed
that the ring-opening polymerizations of lactides and lactones
initiated by either 3 or
2 in the presence of equivalent
2-propanol are living, to provide polymers and block copolymers
of controlled molecular weights and tailored end-groups. The
polymerizations were first-order in monomer up to high
conversions, in which the in
situ initiating system 2/2-propanol revealed no induction period
and much faster polymerization kinetics as compared to
3. 相似文献
7.
Journal of Scheduling - Employee absences are inevitable in practice due to illness, heavy workloads or accidents. These unforeseen events result in the disruption of employee shift rosters, which... 相似文献
8.
Renaud Merlet Louis Winnubst Arian Nijmeijer Mohammad Amirilargani Ernst J. R. Sudhölter Louis C. P. M. de Smet Sara Salvador Cob Pieter Vandezande Matthieu Dorbec Soraya Sluijter Henk van Veen Yvonne VanDelft Ingrid Wienk Petrus Cuperus Subhalaxmi Behera Yusak Hartanto Ivo F. J. Vankelecom Patrick de Wit 《化学,工程师,技术》2021,93(9):1389-1395
Organic solvent nanofiltration (OSN) is gradually expanding from academic research to industrial implementation. The need for membranes with low and sharp molecular weight cutoffs that are able to operate under aggressive OSN conditions is increasing. However, the lack of comparable and uniform performance data frustrates the screening and membrane selection for processes. Here, a collaboration is presented between several academic and industrial partners analyzing the separation performance of 10 different membranes using three model process mixtures. Membrane materials range from classic polymeric and thin film composites (TFCs) to hybrid ceramic types. The model solutions were chosen to mimic cases relevant to today's industrial use: relatively low molar mass solutes (330–550 Da) in n-heptane, toluene, and anisole. 相似文献
9.
Tom Schrijvers Guido Tack Pieter Wuille Horst Samulowitz Peter J. Stuckey 《Constraints》2013,18(2):269-305
The ability to model search in a constraint solver can be an essential asset for solving combinatorial problems. However, existing infrastructure for defining search heuristics is often inadequate. Either modeling capabilities are extremely limited or users are faced with a general-purpose programming language whose features are not tailored towards writing search heuristics. As a result, major improvements in performance may remain unexplored. This article introduces search combinators, a lightweight and solver-independent method that bridges the gap between a conceptually simple modeling language for search (high-level, functional and naturally compositional) and an efficient implementation (low-level, imperative and highly non-modular). By allowing the user to define application-tailored search strategies from a small set of primitives, search combinators effectively provide a rich domain-specific language (DSL) for modeling search to the user. Remarkably, this DSL comes at a low implementation cost to the developer of a constraint solver. The article discusses two modular implementation approaches and shows, by empirical evaluation, that search combinators can be implemented without overhead compared to a native, direct implementation in a constraint solver. 相似文献
10.