排序方式： 共有6条查询结果，搜索用时 0 毫秒
1
1.
Di Wu Meng Qin Duo Xu Lan Wang Chaoyong Liu Jie Ren George Zhou Chen Chen Fengmei Yang Yanyan Li Yuan Zhao Ruyi Huang Sina Pourtaheri Chunsheng Kang Masakazu Kamata Irvin S. Y. Chen Zhanlong He Jing Wen Wei Chen Yunfeng Lu 《Advanced materials (Deerfield Beach, Fla.)》2019,31(18)
Central nervous system (CNS) diseases are the leading cause of morbidity and mortality; their treatment, however, remains constrained by the blood–brain barrier (BBB) that impedes the access of most therapeutics to the brain. A CNS delivery platform for protein therapeutics, which is achieved by encapsulating the proteins within nanocapsules that contain choline and acetylcholine analogues, is reported herein. Mediated by nicotinic acetylcholine receptors and choline transporters, such nanocapsules can effectively penetrate the BBB and deliver the therapeutics to the CNS, as demonstrated in mice and non‐human primates. This universal platform, in general, enables the delivery of any protein therapeutics of interest to the brain, opening a new avenue for the treatment of CNS diseases. 相似文献
2.
3.
4.
5.
Duo Xu Di Wu Meng Qin Lina R. Nih Chaoyong Liu Zheng Cao Jie Ren Xiangjun Chen Zhanlong He Wenhai Yu Jiaoqiong Guan Suqin Duan Fang Liu Xiangsheng Liu Jesse Li Dushawn Harley Bin Xu Lihua Hou Irvin S. Y. Chen Jing Wen Wei Chen Sina Pourtaheri Yunfeng Lu 《Advanced materials (Deerfield Beach, Fla.)》2019,31(33)
The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood–brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule‐based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases. 相似文献
6.
Duo Xu Di Wu Meng Qin Lina R. Nih Chaoyong Liu Zheng Cao Jie Ren Xiangjun Chen Zhanlong He Wenhai Yu Jiaoqiong Guan Suqin Duan Fang Liu Xiangsheng Liu Jesse Li Dushawn Harley Bin Xu Lihua Hou Irvin S. Y. Chen Jing Wen Wei Chen Sina Pourtaheri Yunfeng Lu 《Advanced materials (Deerfield Beach, Fla.)》2019,31(33)
1