华润置地广安门生态展廊设计

这个＂悬浮的装置＂位于北京广安门地区的高耸楼群之中,是为华润置地广安门项目销售与生态展示所设计的一个使用期限约为3年的临时性建筑。     

面向二维GIS矢量数据三维可视化的地形匹配技术研究

提出一种二维GIS矢量数据三维可视化过程中地物与地形的快速匹配方法.结合矢量所代表地物的特性,对基于矢量信息的三维地物进行了分类,综合采用了地物匹配地形和地形匹配地物两种方法.地物匹配地形算法通过实时调整地物的位置和姿态实现与地形的匹配,地形匹配地物算法以不同的距离度量为基础,对矢量约束域内地形进行变形操作实现匹配.本算法还讨论了原始地形数据分辨率较低以及多个地形匹配影响域相交等特殊情况的处理方法.试验结果表明,本方法能满足基于点、线、面矢量信息的三维地物与地形的匹配需求,实现地物与地形无缝结合及平滑过渡,从而达到改善视觉效果的目的.     

Manipulating Estrogenic/Anti-Estrogenic Activity of Triphenylethylenes towards Development of Novel Anti-Neoplastic SERMs

Selective estrogen receptor modulators (SERMs) act as estrogen receptor (ERα) agonists or antagonists depending on the target issue. Tamoxifen (TAM) (a non-steroidal triphenylethylene derivative) was the first SERM approved as anti-estrogen for the treatment of metastatic breast cancer. On the hunt for novel SERMs with potential growth inhibitory activity on breast cancer cell lines yet no potential to induce endometrial carcinoma, we designed and synthesized 28 novel TAM analogs. The novel analogs bear a triphenylethylene scaffold. Modifications on rings A, B, and C aim to attenuate estrogenic/anti-estrogenic activities of the novel compounds so they can potentially inhibit breast cancer and provide positive, beneficial estrogenic effects on other tissues with no risk of developing endometrial hyperplasia. Compound 12 (E/Z-1-(2-{4-[1-(4-Chloro-phenyl)-2-(4-methoxy-phenyl)-propenyl]-phenoxy}-ethyl)-piperidine) showed an appreciable relative ERα agonistic activity in a yeast estrogen screen (YES) assay. It successfully inhibited the growth of the MCF-7 cell line with GI₅₀ = 0.6 µM, and it was approximately three times more potent than TAM. It showed no potential estrogenicity on Ishikawa endometrial adenocarcinoma cell line via assaying alkaline phosphatase (AlkP) activity. Compound 12 was tested in vivo to assess its estrogenic properties in an uterotrophic assay in an ovariectomized rat model. Compared to TAM, it induced less increase in wet uterine wet weight and showed no uterotrophic effect. Compound 12 is a promising candidate for further development due to its inhibition activity on MCF-7 proliferation with moderate AlkP activity and no potential uterotrophic effects. The in vitro estrogenic activity encourages further investigations toward potential beneficial properties in cardiovascular, bone, and brain tissues.     

悦丰岛有机农场系列——采摘亭,昆山,江苏,中国

评语/Jury Comments:这是一个将清晰的设计概念和精准的技术选择充分贯彻的项目,并且营造了融入自然的空间氛围。□This project,out of clear design concepts and precise technical choices,create