Theory of rough surface effects on the anisotropic BCS states

We present a Green's function theory of the rough surface effects on the anisotropic BCS states using the formulation developed in the randomly rippled wall model. It is shown that the randomly rippled wall formulation is general enough to treat rough surface effects from the specular limit to the diffusive limit. We propose a statistical wall configuration such that gives the diffusive limit in the normal state. Within the weak coupling theory, we give a formal solution of the quasi-classical Green's function in a slab geometry and in a semi-infinite geometry with arbitrarily rough surfaces. The formal solution already satisfies the boundary condition. In the diffusive limit, the present theory correctly recovers the linearized gap equation obtained by Kjäldman et al. for the p-wave state in a slab geometry.     

Alteration of substrate specificity of cholesterol oxidase from Streptomyces sp. by site-directed mutagenesis

Despite the structural similarities between cholesterol oxidasefrom Streptomyces and that from Brevibacterium, both enzymesexhibit different characteristics, such as catalytic activity,optimum pH and temperature. In attempts to define the molecularbasis of differences in catalytic activity or stability, substitutionsat six amino acid residues were introduced into cholesteroloxidase using site-directed mutagenesis of its gene. The aminoacid substitutions chosen were based on structural comparisonsof cholesterol oxidases from Streptomyces and Brevibacterium.Seven mutant enzymes were constructed with the following aminoacid substitutions: L117P, L119A, L119F, V145Q, Q286R, P357Nand S379T. All the mutant enzymes exhibited activity with theexception of that with the L117P mutation. The resulting V145Qmutant enzyme has low activities for all substrates examinedand the S379T mutant enzyme showed markedly altered substratespecificity compared with the wild-type enzyme. To evaluatethe role of V145 and S379 residues in the reaction, mutantswith two additional substitutions in V145 and four in S379 wereconstructed. The mutant enzymes created by the replacement ofV145 by Asp and Glu had much lower catalytic efficiency forcholesterol and pregnenolone as substrates than the wild-typeenzyme. From previous studies and this study, the V145 residueseems to be important for the stability and substrate bindingof the cholesterol oxidase. In contrast, the catalytic efficiencies(k_cat/K_m) of the S379T mutant enzyme for cholesterol and pregnenolonewere 1.8- and 6.0-fold higher, respectively, than those of thewild-type enzyme. The enhanced catalytic efficiency of the S379Tmutant enzyme for pregnenolone was due to a slightly high k_catvalue and a low K_m value. These findings will provide severalideas for the design of more powerful enzymes that can be appliedto clinical determination of serum cholesterol levels and assterol probes.     

Rough Surface Effects on the p-Wave Fermi Superfluids

Rough surface effects on p-wave Fermi superfluids are discussed on the basis of our recently proposed quasi-classical theory that can treat in a unified way the surface scattering ranging from the specular limit to the diffusive limit. We show how the transition temperature of the ABM state in a slab geometry depends on the surface roughness. In the diffusive limit, our result agrees with Kjäldmann et al. We consider the BW state, the ABM state and the polar state in a half-infinite geometry with a plane rough surface and discuss the self-consistent order parameter and the surface density of states at low temperatures. The rough surface effects on the Andreev scattering in the BW state are also discussed within the same framework.     

E2011 a novel, selective and reversible inhibitor of monoamine oxidase type A

E2011, (5R)-3-[2-((1S)-3-cyano-1hydroxypropyl)benzothiazol- 6-yl]-5-methoxymethyl-2-oxazolidine, is a novel inhibitor of monoamine oxidase type A (MAO-A). We have characterized the neurochemical and pharmacological profiles of E2011 and compared them with those of known inhibitors of MAO-A. E2011 potently inhibited MAO-A with more than 30,000 times higher selectivity for MAO-A relative to MAO-B in rat brain homogenate. E2011 did not affect putative neural receptors or reuptake of biogenic amines into synaptosomes of rat brain, which suggests that it is specific to monoaminergic systems. In vivo, E2011 at a dose of 0.3 mg/kg p.o. exhibited potent MAO-A inhibitory activity, whereas MAO-B inhibition was not observed even at 100 mg/kg p.o. E2011 inhibited monoamine metabolism in the rat brain, but the effect disappeared 24 h after administration. Like other reversible MAO-A inhibitors, E2011 did not show a cumulative inhibitory effect during repeated administration for 7 days. However, inhibition of MAO-A by E2011 in ex vivo experiments appeared to be less potent than that by moclobemide. The MAO-A inhibition by E2011 was partially but significantly reversed by dialysis at 4 degrees C for 24 h, which indicates that E2011 could be dissociated from the enzyme. These findings suggest that E2011 is a reversible and highly selective inhibitor of MAO-A. The potency of inhibition by highly reversible MAO-A inhibitors such as E2011 is likely to be underestimated in ex vivo studies because of dilution of the homogenate in the assay system.     

Energy transmission transformer for a wireless capsule endoscope: analysis of specific absorption rate and current density in biological tissue

This paper reports on the electromagnetic influences on the analysis of biological tissue surrounding a prototype energy transmission system for a wireless capsule endoscope. Specific absorption rate (SAR) and current density were analyzed by electromagnetic simulator in a model consisting of primary coil and a human trunk including the skin, fat, muscle, small intestine, backbone, and blood. First, electric and magnetic strength in the same conditions as the analytical model were measured and compared to the analytical values to confirm the validity of the analysis. Then, SAR and current density as a function of frequency and output power were analyzed. The validity of the analysis was confirmed by comparing the analytical values with the measured ones. The SAR was below the basic restrictions of the International Commission on Nonionizing Radiation Protection (ICNIRP). At the same time, the results for current density show that the influence on biological tissue was lowest in the 300-400 kHz range, indicating that it was possible to transmit energy safely up to 160 mW. In addition, we confirmed that the current density has decreased by reducing the primary coil's current.     

Proximity Effect between a Dirty Fermi Liquid and Superfluid 3He

The proximity effect in superfluid ³He partly filled with high porosity aerogel is discussed. This system can be regarded as a dirty Fermi liquid/spin-triplet p-wave superfluid junction. Our attention is mainly paid to the case when the dirty layer is in the normal state owing to the impurity pair-breaking effect by the aerogel. We use the quasiclassical Green’s function to determine self-consistently the spatial variations of the p-wave order parameter and the impurity self-energy. On the basis of the fully self-consistent calculation, we analyze the spatial dependence of the pair function (anomalous Green’s function). The spin-triplet pair function has in general even-frequency odd-parity and odd-frequency even-parity components. We show that the admixture of the even- and odd-frequency pairs occurs near the aerogel/superfluid ³He-B interface. Among those Cooper pairs, only the odd-frequency s-wave pair can penetrate deep into the aerogel layer. As a result, the proximity-induced superfluidity in a thick aerogel layer is dominated by the Cooper pair with the odd-frequency s-wave symmetry. We also analyze the local density of states and show that it has a characteristic zero-energy peak reflecting the existence of the odd-frequency s-wave pair, in agreement with previous works using the Usadel equation.     

An unusual parotid gland in the tent-building bat, Uroderma bilobatum: possible correlation of interspecific ultrastructural differences with differences in salivary pH and buffering capacity

PURPOSE: To determine the utility and accuracy of helical CT angiography (CTA) in the evaluation of carotid artery stenosis. METHODS: A comparison of CTA and conventional arteriogram was performed in 53 patients undergoing evaluation for carotid artery stenosis. Ninety-six carotid systems were evaluable. CTA stenosis was determined by the percent of area reduction seen on axial images through the level of greatest narrowing. MIP images were used to identify the point of maximal stenosis and to visualize overall vascular anatomy. The percent diameter stenosis was measured on conventional arteriograms using strict North American Symptomatic Carotid Endarterectomy Trial (NASCET) and European Carotid Surgery Trial (ECST) criteria. RESULTS: Significant correlation was found between CTA and arteriography (NASCET method R=0.87, ECST method R=0.87, p < 0.001). Using NASCET >60% as an indicator for disease, CTA had a sensitivity of 87%, specificity of 90%, accuracy of 89%, negative predictive value of 88%, and positive predictive value of 89%. CTA identified plaque characteristics such as ulcerations (8), occlusion (10), fatty plaques (22), calcifications (48), and fibrosis (2). CTA underestimated 2 cases of short segment stenoses because of volume averaging, but this discrepancy was detected by duplex scan. No complications or renal dysfunction occurred with CTA; 1 patient became symptomatic during arteriography, necessitating termination of the procedure. CONCLUSION: CTA is a safe, non-invasive technique that precisely measures carotid artery area reduction and highly correlates to conventional arteriography. With this new technology, the current standards for carotid artery imaging may need to be reevaluated, and the precise role for helical CTA more clearly defined.     

Theory of Acoustic Impedance of Superfluid 3He

No Heading A microscopic theory of transverse acoustic impedance of superfluid ³He at low temperatures is presented. we calculate the stress tensor of superfluid ³He as a response to the oscillating rough wall. For that purpose, we extend a quasi-classical theory based on the random S-matrix model to time dependent problems. We show that by virtue of the pair breaking mechanism the transverse impedance can be finite even at T=0 K. This is in contrast to the theories using the quasi-particle distribution function which predict that the impedance tends to zero like a Yosida function.PACS numbers: 67.57.Np, 67.57.Jj     

Laser-assisted replication of large-area nanostructures

We proposed and demonstrated a high-throughput fabrication method for large-area nanostructured polymers. The mold used consists of a quartz substrate and a nanostructured diamond-like carbon (DLC) thin film. A laser is irradiated from the back of the mold and only the DLC surface is directly heated. Then the surface of a polymethyl methacrylate (PMMA) film pressed by the mold is melted and the nanostructures are replicated. In this method, replication can be achieved with a low amount of heat and a short cycle time compared with conventional thermal replication. The effects of the laser power density, irradiation time, and environmental temperature on the replication area were experimentally investigated via the spot irradiation of a laser. Furthermore, the temperature distribution around the surfaces of the mold and polymer was investigated by performing numerical simulations. By scanning the laser, we successfully demonstrated the replication of a 500-nm-pitch pattern on a PMMA film with an area of 10 × 10 mm² in about 10 s. This technique is expected to lead to the high-throughput and low-energy fabrication of large-area nanostructured optical films.