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排序方式: 共有176条查询结果,搜索用时 15 毫秒
1.
Mootaz M. Salman Zaid Al-Obaidi Philip Kitchen Andrea Loreto Roslyn M. Bill Richard Wade-Martins 《International journal of molecular sciences》2021,22(9)
Neurodegenerative diseases (NDs) including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease are incurable and affect millions of people worldwide. The development of treatments for this unmet clinical need is a major global research challenge. Computer-aided drug design (CADD) methods minimize the huge number of ligands that could be screened in biological assays, reducing the cost, time, and effort required to develop new drugs. In this review, we provide an introduction to CADD and examine the progress in applying CADD and other molecular docking studies to NDs. We provide an updated overview of potential therapeutic targets for various NDs and discuss some of the advantages and disadvantages of these tools. 相似文献
2.
Adnan Hasan Bdair Aighuraibawi Selvakumar Manickam Rosni Abdullah Zaid Abdi Alkareem Alyasseri Ayman Khallel Dilovan Asaad Zebari Hussam Mohammed Jasim Mazin Mohammed Abed Zainb Hussein Arif 《计算机系统科学与工程》2023,47(1):553-574
Internet Protocol version 6 (IPv6) is the latest version of IP that goal to host 3.4 × 1038 unique IP addresses of devices in the network. IPv6 has introduced new features like Neighbour Discovery Protocol (NDP) and Address Auto-configuration Scheme. IPv6 needed several protocols like the Address Auto-configuration Scheme and Internet Control Message Protocol (ICMPv6). IPv6 is vulnerable to numerous attacks like Denial of Service (DoS) and Distributed Denial of Service (DDoS) which is one of the most dangerous attacks executed through ICMPv6 messages that impose security and financial implications. Therefore, an Intrusion Detection System (IDS) is a monitoring system of the security of a network that detects suspicious activities and deals with a massive amount of data comprised of repetitive and inappropriate features which affect the detection rate. A feature selection (FS) technique helps to reduce the computation time and complexity by selecting the optimum subset of features. This paper proposes a method for detecting DDoS flooding attacks (FA) based on ICMPv6 messages using a Binary Flower Pollination Algorithm (BFPA-FA). The proposed method (BFPA-FA) employs FS technology with a support vector machine (SVM) to identify the most relevant, influential features. Moreover, The ICMPv6-DDoS dataset was used to demonstrate the effectiveness of the proposed method through different attack scenarios. The results show that the proposed method BFPA-FA achieved the best accuracy rate (97.96%) for the ICMPv6 DDoS detection with a reduced number of features (9) to half the total (19) features. The proven proposed method BFPA-FA is effective in the ICMPv6 DDoS attacks via IDS. 相似文献
3.
Zaid M. Odibat Cyrille Bertelle M.A. Aziz-Alaoui Gérard H.E. Duchamp 《Computers & Mathematics with Applications》2010,59(4):1462-1472
The differential transform method (DTM) is an analytical and numerical method for solving a wide variety of differential equations and usually gets the solution in a series form. In this paper, we propose a reliable new algorithm of DTM, namely multi-step DTM, which will increase the interval of convergence for the series solution. The multi-step DTM is treated as an algorithm in a sequence of intervals for finding accurate approximate solutions for systems of differential equations. This new algorithm is applied to Lotka–Volterra, Chen and Lorenz systems. Then, a comparative study between the new algorithm, multi-step DTM, classical DTM and the classical Runge–Kutta method is presented. The results demonstrate reliability and efficiency of the algorithm developed. 相似文献
4.
Khamirul Amin Matori Loy Chee Wah Mansor Hashim Ismayadi Ismail Mohd Hafiz Mohd Zaid 《International journal of molecular sciences》2012,13(12):16812-16821
We report on a recycling project in which α-Al2O3 was produced from aluminum cans because no such work has been reported in literature. Heated aluminum cans were mixed with 8.0 M of H2SO4 solution to form an Al2(SO4)3 solution. The Al2(SO4)3 salt was contained in a white semi-liquid solution with excess H2SO4; some unreacted aluminum pieces were also present. The solution was filtered and mixed with ethanol in a ratio of 2:3, to form a white solid of Al2(SO4)3·18H2O. The Al2(SO4)3·18H2O was calcined in an electrical furnace for 3 h at temperatures of 400–1400 °C. The heating and cooling rates were 10 °C/min. XRD was used to investigate the phase changes at different temperatures and XRF was used to determine the elemental composition in the alumina produced. A series of different alumina compositions, made by repeated dehydration and desulfonation of the Al2(SO4)3·18H2O, is reported. All transitional alumina phases produced at low temperatures were converted to α-Al2O3 at high temperatures. The X-ray diffraction results indicated that the α-Al2O3 phase was realized when the calcination temperature was at 1200 °C or higher. 相似文献
5.
Ibrahim I. T. Attallah K. H. Elsaid M. Fahmy M. H. Abo Zaid L. A. 《Radiochemistry》2019,61(2):220-225
Radiochemistry - Aspirin, one of nonsteroidal anti-inflammatory analgesic drugs, was labeled with 125I with a labeling yield of 85.5% under the following conditions: pH 9, 100 mg of the substrate,... 相似文献
6.
Abdellah Tebani Lahouaria Zanoutene-Cheriet Zoubir Adjtoutah Lenaig Abily-Donval Carole Brasse-Lagnel Annie Laquerrière Stephane Marret Abla Chalabi Benabdellah Soumeya Bekri 《International journal of molecular sciences》2016,17(5)
Mucopolysaccharidoses (MPS’s) represent a subgroup of lysosomal storage diseases related to a deficiency of enzymes that catalyze glycosaminoglycans degradation. Mucopolysaccharidosis type I (MPS I) is a rare autosomal recessive disorder caused by a deficiency of α-l-iduronidase encoded by the IDUA gene. Partially degraded heparan sulfate and dermatan sulfate accumulate progressively and lead to multiorgan dysfunction and damage. The aim of this study is to describe the clinical, biochemical, and molecular characteristics of 13 Algerian patients from 11 distinct families. MPS I diagnosis was confirmed by molecular study of the patients’ IDUA gene. Clinical features at the diagnosis and during the follow-up are reported. Eighty-four percent of the studied patients presented with a mild clinical phenotype. Molecular study of the IDUA gene allowed the characterization of four pathological variations at the homozygous or compound heterozygote status: IDUA NM_00203.4:c.1598C>G-p.(Pro533Arg) in 21/26 alleles, IDUA NM_00203.4:c.532G>A-p.(Glu178Lys) in 2/26 alleles, IDUA NM_00203.4:c.501C>G-p.(Tyr167*) in 2/26 alleles, and IDUA NM_00203. 4: c.1743C>G-p.(Tyr581*) in 1/26 alleles. This molecular study unveils the predominance of p.(Pro533Arg) variation in our MPS I patients. In this series, the occurrence of some clinical features linked to the Scheie syndrome is consistent with the literature, such as systematic valvulopathies, corneal opacity, and umbilical hernia; however, storage signs, facial dysmorphic features, and hepatomegaly were more frequent in our series. Screening measures for these debilitating diseases in highly consanguineous at-risk populations must be considered a priority health problem. 相似文献
7.
Effects of pH and chloride concentration on pitting corrosion of AA6061 aluminum alloy 总被引:1,自引:0,他引:1
Effects of pH solution and chloride (Cl−) ion concentration on the corrosion behaviour of alloy AA6061 immersed in aqueous solutions of NaCl have been investigated using measurements of weight loss, potentiodynamic polarisation, linear polarisation, cyclic polarisation experiment combined with open circuit potential transient technique and optical or scanning electron microscopy.The corrosion behaviour of the AA6061 aluminum alloy was found to be dependant on the pH and chloride concentration [NaCl] of solution. In acidic or slightly neutral solutions, general and pitting corrosion occurred simultaneously. In contrast, exposure to alkaline solutions results in general corrosion. Experience revealed that the alloy AA6061 was susceptible to pitting corrosion in all chloride solution of concentration ranging between 0.003 wt% and 5.5 wt% NaCl and an increase in the chloride concentration slightly shifted both the pitting Epit and corrosion Ecor potentials to more active values. In function of the conditions of treatment, the sheets of the alloy AA6061 undergo two types of localised corrosion process, leading to the formation of hemispherical and crystallographic pits.Polarisation resistance measurements in acidic (pH = 2) and alkaline chloride solutions (pH = 12) which are in good agreement with those of weight loss, show that the corrosion kinetic is minimised in slightly neutral solutions (pH = 6). 相似文献
8.
9.
A. Chalabi 《Calcolo》1982,19(3):269-300
This paper deals with the study of the problem of long waves in shallow water, when viscesity is taken into account. Existence
and uniqueness of the solution are established. For the numerical treatment, an implicit scheme is proposed together with
results of stability and convergence.
Le présent travail a été réalisé au Laboratoire de Matématiques Appliquees de l'Université Scientitique et Médicale de Grenoble (France). 相似文献
Le présent travail a été réalisé au Laboratoire de Matématiques Appliquees de l'Université Scientitique et Médicale de Grenoble (France). 相似文献
10.
H. M. Zaid A. P. G. Robinson R. E. Palmer M. Manickam J. A. Preece 《Advanced functional materials》2007,17(14):2522-2527
Molecular resists, such as triphenylene derivatives, are small carbon rich molecules, and thus give the potential for higher lithographic resolution and etch durability, and lower line width roughness than traditional polymeric compounds. Their main limitation to date has been poor sensitivity. A new triphenylene derivative molecular resist, with pendant epoxy groups to aid chemically amplified crosslinking, was synthesized and characterized. The sensitivity of the negative tone, pure triphenylene derivative when exposed to an electron beam with energy 20 keV was ~ 6 × 10–4 C cm–2, which increased substantially to ~ 1.5 × 10–5 C cm–2 after chemical amplification (CA) using a cationic photoinitiator. This was further improved, by the addition of a second triphenylene derivative, to ~ 7 × 10–6 C cm–2. The chemically amplified resist demonstrated a high etch durability comparable with the novolac resist SAL 601. Patterns with a minimum feature size of ~ 40 nm were realized in the resist with a 30 keV electron beam. 相似文献