Bee Bread Ameliorates Vascular Inflammation and Impaired Vasorelaxation in Obesity-Induced Vascular Damage Rat Model: The Role of eNOS/NO/cGMP-Signaling Pathway

Obesity and hyperlipidemia are major risk factors for developing vascular diseases. Bee bread (BB) has been reported to exhibit some biological actions, including anti-obesity and anti-hyperlipidemic. This study aims to investigate whether bee bread can ameliorate vascular inflammation and impaired vasorelaxation activity through eNOS/NO/cGMP pathway in obese rats. Forty male Sprague-Dawley rats were randomly divided into four groups (n = 10/group), namely: control (normal group), obese rats (OB group), obese rats treated with bee bread (0.5 g/kg/day, OB/BB group) and obese rats treated with orlistat (10 mg/kg/day, OB/OR group). The latter three groups were given a high-fat diet (HFD) for 6 weeks to induced obesity before being administered with their respective treatments for another 6 weeks. After 12 weeks of the total experimental period, rats in the OB group demonstrated significantly higher Lee obesity index, lipid profile (total cholesterol, triglyceride, low-density lipoprotein), aortic proinflammatory markers (tumor necrosis factor-α, nuclear factor-κβ), aortic structural damage and impairment in vasorelaxation response to acetylcholine (ACh). Bee bread significantly ameliorated the obesity-induced vascular damage manifested by improvements in the lipid profile, aortic inflammatory markers, and the impaired vasorelaxation activity by significantly enhancing nitric oxide release, promoting endothelial nitric oxide synthase (eNOS) and cyclic guanosine monophosphate (cGMP) immunoexpression. These findings suggest that the administration of bee bread ameliorates the impaired vasorelaxation response to ACh by improving eNOS/NO/cGMP-signaling pathway in obese rats, suggesting its vascular therapeutic role.     

A new deep convolutional neural network model for classifying breast cancer histopathological images and the hyperparameter optimisation of the proposed model

The Journal of Supercomputing - Deep learning algorithms have yielded remarkable results in medical diagnosis and image analysis, besides their contribution to improvements in a number of fields...     

A novel double-circuit-rotor balanced induction motor for improvedslip-energy recovery drive performance. I. Modeling and simulation

A new construction for the rotor windings of balanced wound-rotor induction motors employed in the slip energy recovery drives is proposed, in this paper, to reduce the time harmonics which are commonly generated in the machine. The proposed machine has a double-circuit in the rotor. One circuit is star connected while the other is delta connected. Each of these two circuits is connected to a diode-bridge rectifier to achieve a twelve-pulse operation characteristics. The main objective of this paper is to develop a new model which is capable of simulating the proposed machine, neglecting nonlinearities due to magnetic saturation, and its associated converters. Such a model is further complicated due to the presence of the two rotor circuits and their mutual interaction     

Nitrogen dioxide effect in the reduction of nitric oxide by propane in oxidizing atmosphere

The role of nitrogen dioxide in the selective reduction of NO by propane over a Cu-MFI zeolite is investigated. NO₂ and NO reductions were carried out under similar conditions of reaction. In the presence of oxygen, the reduction of NO by C₃H₈ does not differ significantly from that of NO₂. In the absence of oxygen, the reduction of NO₂ by propane occurs with a partial decomposition of the nitric dioxide molecule. Such a decomposition leads to the formation of oxygen, which is responsible for the increase in catalytic activity by comparison with the same reaction performed with NO. NO₂ formed and released in the gas phase during the reduction of NO by propane in the presence of oxygen does not play a predominant role in the catalytic process.     

Privacy issues in a psychiatric context: applying the ISD privacy framework to a psychiatric behavioural monitoring system

Privacy issues are frequently discussed amongst researchers, practitioners and patients in healthcare. However, psychiatric patients’ privacy issues get less attention in information system development (ISD), whereby they are one of the most important stakeholders. This paper applies Carew and Stapleton’s ISD privacy framework to psychiatric monitoring systems to understand the issues that are related to monitoring psychiatric patients’ behaviour. By understanding the privacy issues amongst patients, the research will be able to provide guidance to system developers to produce a privacy-sensitive system that can contribute to the system engineering for international stability. We will elaborate each factor in the framework (physical, social, psychological and informational) and then explain the relationship to the privacy of psychiatric patient.     

Fourier transform infrared (FTIR) authentication and batch-to-batch consistency for different types of paints using benchtop and handheld FTIR spectrophotometers for oil and gas industry

Standardization of Fourier transform infrared (FTIR) fingerprint region for paints and assessment on the reproducibility using different spectrophotometers were investigated. While selective fingerprint regions may be confusing for technicians/analysts who are non-chemists, we attempt to generalize these regions (e.g., 1300–1000 cm⁻¹ for Epoxy part A and 1400–1000 cm⁻¹ for Epoxy part B) by choosing a universal region (2000–900 cm⁻¹) that works for different paints. Comparison result using a paired student t-test shows that the degree of similarity (r) values from the studied regions are not statistically different. The paint fails the screening analysis occasionally on-site when analyzed using handheld FTIR due to the higher level of noise that gives low r values (r < 0.900 ± 0.002). The same samples were analyzed using a benchtop FTIR and the r values are above 0.900 ± 0.002. While the screening may lead to a false rejection of the sample on-site, there could be occurrence of false acceptance. The on-site screening of EPZ part A with different formulations, for instance, shows that the r values over the entire IR spectrum are above 0.900 ± 0.002 when analyzed using handheld FTIR. After the samples were analyzed using the benchtop, the r values fall below 0.900 ± 0.002.     

Blending science and public policies for remediation of a degraded ecosystem: Jackfish Bay, north shore of Lake Superior, Ontario, Canada

The Jackfish Bay Remedial Action Plan is the first of Lake Superior's Areas of Concern (AOCs) to consider recognition as an Area in Recovery (AiR). As a result of a high degree of complexity and uncertainty, ecosystem recovery in Jackfish Bay has been determined using a combination of regulatory policies and scientific evidence and extensive public and expert-based decision making. As a result, the conceptualization of the AiR status in Jackfish Bay has been developed with the adaptive management and the ecosystem approach, which provide the basic principles of assessing, monitoring, and managing the Area of Concern. To determine the status of beneficial use impairments caused by effluent from the Terrace Bay Pulp Inc., three public advisory committees—an academic panel of experts, a government technical review committee, and the Jackfish Bay Public Area in Recovery Review Committee (PARRC)—reviewed relevant scientific data and documents, including peer-reviewed publications, to assess changes in pollution levels in Jackfish Bay and improvements to aquatic, biotic, and benthic environments of the bay. The public decision-making process concluded with recommendations by the PARRC to develop a systematic monitoring program so that the ecosystem recovery process in the bay could be assessed on a continued basis, leading to its eventual delisting as an AOC. The entire process provides an example of blending science and public policies for remediation of a degraded ecosystem on the Great Lakes.     

A new approach based on a discrete hidden Markov model using the Rocchio algorithm for the diagnosis of heart valve diseases

Abstract: Application of the Doppler ultrasound technique in the diagnosis of heart diseases has been increasing in the last decade since it is non‐invasive, practicable and reliable. In this study, a new approach based on the discrete hidden Markov model (DHMM) is proposed for the diagnosis of heart valve disorders. For the calculation of hidden Markov model (HMM) parameters according to the maximum likelihood approach, HMM parameters belonging to each class are calculated by using training samples that only belong to their own classes. In order to calculate the parameters of DHMMs, not only training samples of the related class but also training samples of other classes are included in the calculation. Therefore HMM parameters that reflect a class's characteristics are more represented than other class parameters. For this aim, the approach was to use a hybrid method by adapting the Rocchio algorithm. The proposed system was used in the classification of the Doppler signals obtained from aortic and mitral heart valves of 215 subjects. The performance of this classification approach was compared with the classification performances in previous studies which used the same data set and the efficiency of the new approach was tested. The total classification accuracy of the proposed approach (95.12%) is higher than the total accuracy rate of standard DHMM (94.31%), continuous HMM (93.5%) and support vector machine (92.67%) classifiers employed in our previous studies and comparable with the performance levels of classifications using artificial neural networks (95.12%) and fuzzy‐C‐means/CHMM (95.12%).     

Ti3AlC2 coated D-shaped fiber saturable absorber for Q-switched pulse generation

In this letter, a titanium aluminum carbide (Ti3AlC2) coated D-shaped fiber is proposed and demonstrated as a new saturable absorber (SA) for Q-switched laser pulse generation. In preparing the SA, the Ti3AlC2 powder is dispersed in liquid polyvinyl alcohol (PVA) before the solution is dropped and left to dry onto a polished surface of D-shape fiber. The SA is added to an erbium-doped fiber laser (EDFL) cavity to modulate the cavity loss for Q-switching. The Q-switched laser is obtained at 1 561 nm. The pulse width of the pulses can be varied between 7.4 µs and 5.1 µs with a corresponding repetition rate range from 41.26 kHz to 54.35 kHz, when the pump power is increased from 42.2 mW to 71.5 mW. At 71.5 mW pump, the pulse energy is obtained at 70.3 nJ. The signal-to-noise ratio (SNR) of the fundamental frequency is recorded at 67 dB, which indicates the stability of the laser.