On‐the‐Spot Immobilization of Quantum Dots,Graphene Oxide,and Proteins via Hydrophobins

Class I hydrophobin Vmh2, a peculiar surface active and versatile fungal protein, is known to self‐assemble into chemically stable amphiphilic films, to be able to change wettability of surfaces, and to strongly adsorb other proteins. Herein, a fast, highly homogeneous and efficient glass functionalization by spontaneous self‐assembling of Vmh2 at liquid–solid interfaces is achieved (in 2 min). The Vmh2‐coated glass slides are proven to immobilize not only proteins but also nanomaterials such as graphene oxide (GO) and quantum dots (QDs). As models, bovine serum albumin labeled with Alexa 555 fluorophore, anti‐immunoglobulin G antibodies, and cadmium telluride QDs are patterned in a microarray fashion in order to demonstrate functionality, reproducibility, and versatility of the proposed substrate. Additionally, a GO layer is effectively and homogeneously self‐assembled onto the studied functionalized surface. This approach offers a quick and simple alternative to immobilize nanomaterials and proteins, which is appealing for new bioanalytical and nanobioenabled applications.     

Squamous cell carcinoma of the prostate: case report and review of literature

Carcinoma of the prostate, that is adenocarcinoma, is one of the most common malignancies in the male with an estimated incidence for 1991 of 122,000 new cases. On the other hand, squamous cell carcinoma of the prostate, with a median incidence of .5%-1% of all prostatic malignancies, has a similar clinical presentation but differs in treatment response and prognosis. We herein present one case of this histological pattern and review the literature pertaining to it.     

Cascade damage evolution: rate theory versus kinetic Monte Carlo simulations

The thermal evolution of defects produced by ion irradiation is studied by kinetic Monte Carlo and Rate Theory approaches. An isochronal annealing is simulated to evidence the different thermally activated mechanisms that govern defect evolution. KMC simulations show that in the case of ion irradiation, additional recovery peaks should be expected, in comparison to electron irradiation conditions. A comparison between kMC and RT results indicates that some of these peaks are due to spatially – correlated recombinations that occur at low temperature. Therefore kMC and RT approaches differ at low temperature. However, at higher temperature results obtained by both models are in near perfect agreement. In addition, we studied the influence of vacancy cluster mobility on the evolution of damage. KMC simulations show that the mobility of V₂, V₃ and V₄ clusters does not significantly affect the evolution of defects and can be neglected in these conditions.     

Red-green colour blindness in the Tormes-Alberche Valley (Avila-Central Spain)

A population from a Central Spanish region (Tormes-Alberche Valley) has been investigated for the presence of red-green colour vision defects. A sample of 998 subjects (469 male and 529 female) was analyzed. To identify colour vision defects, Ishihara test plates were used. The red-green colour blindness percentage obtained was 4.69 +/- 0.976% for males (2.13% protan and 2.56% deutan types) and none of the females tested were found to be colour blind. These results are within the variation range of Mediterranean populations and lower than the usual frequencies among non-Mediterranean European samples.     

Reasons for the autonomous community of Aragon's position against the Ebro transfer as envisaged in the national hydrological plan

The present paper outlines the views of the Government of Aragon on the National Hydrological Plan of Spain. It concludes that the transfer of water from the Ebro River will accentuate the differences among some regions of Spain in terms of their development potentials. It will unquestionably constrain the future development of regions that are already disadvantaged, such as Aragon. Alternatives are proposed where the regions in need of water can obtain it, but without adversely affecting the economic, social and environmental sustainability of the region and the people of Aragon.     

Hierarchical Self‐Assembly of Peptide‐Coated Carbon Nanotubes

Numerous applications, from molecular electronics to super‐strong composites, have been suggested for carbon nanotubes. Despite this promise, difficulty in assembling raw carbon nanotubes into functional structures is a deterrent for applications. In contrast, biological materials have evolved to self‐assemble, and the lessons of their self‐assembly can be applied to synthetic materials such as carbon nanotubes. Here we show that single‐walled carbon nanotubes, coated with a designed amphiphilic peptide, can be assembled into ordered hierarchical structures. This novel methodology offers a new route for controlling the physical properties of nanotube systems at all length scales from the nano‐ to the macroscale. Moreover, this technique is not limited to assembling carbon nanotubes, and could be modified to serve as a general procedure for controllably assembling other nanostructures into functional materials.     

Analysis and Design of Robust Controllers Using the Interval Diophantine Equation

In this paper the design of pole placement feedback controllers for interval plants is addressed within an Interval Analysis framework. Three main topics connected by the concept of interval Diophantine equation are treated: a relatively straightforward investigation about robust coprimeness of interval polynomials, a reliable computing approach for the design of pole placement controllers in the presence of inaccuracies of interval type, and the design of robust controllers with regional pole placement specifications. After explicitly characterizing a convex subset of robust controllers, the problem of designing non-fragile controllers is formulated as a design centering problem, which is then solved by a global optimization algorithm. Numerical examples illustrate the main characteristics of the approach proposed.This paper has been partially supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico–Brazil.     

On the impact of physical layer awareness on scheduling and resource allocation in broadband multicellular IEEE 802.16 systems [Radio Resource Management and Protocol Engineering for IEEE 802.16]

Multicellular networks based on the IEEE 802.16 standard appear to be very promising candidates to provide end users with broadband wireless access. However, they also pose interesting challenges in terms of radio resource management, where several design choices are not specified in the standard, intentionally left open to implementors. For this reason, we focus in this article on scheduling and resource allocation, and investigate how they could operate in a cross-layer fashion. In particular, we describe the principles of joint scheduling and resource allocation for IEEE 802.16 operating in AMC mode, and discuss the critical role played by physical layer considerations, especially intercell interference estimation and channel state awareness, in the obtained performance. This leads to identifying key open issues and possible general solutions     

Shumbler: a 155 Mb/s BiCMOS synchronous multiplexer chip for abroad-band customer premises network

The shumbler (shuffler/scrambler) is a circuit designed and fabricated to form part of a broadband customer premises network. The circuit is implemented in 1.2-μm BiCMOS double-metal technology. The circuit is bidirectional, and can perform the functions of scrambling and shuffling or descrambling and unshuffling by means of control signals to three integrated multiplexers. The shumbler also includes a programmable multiplexer that allows the selection of one out of the 16 output channels of the shuffler through a serial output for local system test purposes. The shumbler circuit interfaces emitter-coupled-logic (ECL) and transistor-transistor-logic (TTL) logic levels using a single power supply of -5 V, dissipating 1.5 W, and encapsulated in a 68-pin LCC package with a flat heat spreader which ensures a thermal resistivity of about 10°C/W