全文获取类型
收费全文 | 227篇 |
免费 | 21篇 |
国内免费 | 2篇 |
专业分类
电工技术 | 6篇 |
综合类 | 1篇 |
化学工业 | 69篇 |
金属工艺 | 5篇 |
机械仪表 | 7篇 |
建筑科学 | 4篇 |
能源动力 | 16篇 |
轻工业 | 23篇 |
水利工程 | 2篇 |
石油天然气 | 1篇 |
无线电 | 27篇 |
一般工业技术 | 51篇 |
冶金工业 | 14篇 |
原子能技术 | 2篇 |
自动化技术 | 22篇 |
出版年
2023年 | 3篇 |
2022年 | 14篇 |
2021年 | 25篇 |
2020年 | 19篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 12篇 |
2014年 | 8篇 |
2013年 | 20篇 |
2012年 | 5篇 |
2011年 | 7篇 |
2010年 | 7篇 |
2009年 | 6篇 |
2008年 | 6篇 |
2007年 | 5篇 |
2006年 | 5篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2003年 | 8篇 |
2002年 | 3篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1998年 | 4篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1993年 | 4篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 1篇 |
1977年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有250条查询结果,搜索用时 31 毫秒
1.
R Bharti 《Canadian Metallurgical Quarterly》1994,66(4):443-448
Fluoroquinolones, a new class of compounds characterised by broad antimicrobial spectrum including mycobacteria together with limited toxicity, have recently been introduced in the chemotherapy of various human infectious diseases. Pefloxacin, one of the members of this class, was recently demonstrated to be bactericidal against M.leprae in the mouse foot-pad model and clinically beneficial in lepromatous leprosy patients. Clinical response to standard MDT with added pefloxacin in ten previously untreated (both PB and MB) was compared with that in ten similar patients on MDT alone in the present trial. The results of chemotherapy were quantified by a method of clinical scoring. This pilot study showed that addition of pefloxacin led to significant and rapid clinical improvement. There were no side effects attributable to pefloxacin. 相似文献
2.
Biswas Uttara Rakshit Jayanta Kumar Das Joyashree Bharti Gaurav Kumar Suthar Bhuvneshwer Amphawan Angela Najjar Monia 《SILICON》2021,13(3):885-892
Silicon - In the present report, a photonic crystal based micro-ring resonator (MRR) structure is proposed which is very compact in size and has very fast response and is employed for temperature... 相似文献
3.
Dr. Richa Sharma Tulika Srivastava Alka Raj Pandey Dr. Tripti Mishra Dr. Bhagyashri Gupta Dr. Sabbu Sathish Reddy Dr. Suriya P. Singh Dr. Tadigoppula Narender Aradhya Tripathi Dr. Balasubramanian Chandramouli Dr. Koneni V. Sashidhara Dr. Smriti Priya Dr. Niti Kumar 《ChemMedChem》2021,16(13):2146-2156
Defective protein folding and accumulation of misfolded proteins is associated with neurodegenerative, cardiovascular, secretory, and metabolic disorders. Efforts are being made to identify small-molecule modulators or structural-correctors for conformationally destabilized proteins implicated in various protein aggregation diseases. Using a metastable-reporter-based primary screen, we evaluated pharmacological chaperone activity of a diverse class of natural products. We found that a flavonoid glycoside ( C-10 , chrysoeriol-7-O-β-D-glucopyranoside) stabilizes metastable proteins, prevents its aggregation, and remodels the oligomers into protease-sensitive species. Data was corroborated with additional secondary screen with disease-specific pathogenic protein. In vitro and cell-based experiments showed that C-10 inhibits α-synuclein aggregation which is implicated in synucleinopathies-related neurodegeneration. C-10 interferes in its structural transition into β-sheeted fibrils and mitigates α-synuclein aggregation-associated cytotoxic effects. Computational modeling suggests that C-10 binds to unique sites in α-synuclein which may interfere in its aggregation amplification. These findings open an avenue for comprehensive SAR development for flavonoid glycosides as pharmacological chaperones for metastable and aggregation-prone proteins implicated in protein conformational diseases. 相似文献
4.
Powder Metallurgy and Metal Ceramics - Powder compaction is the most crucial process in powder metallurgy since almost all the desired properties of a material, such as a shape, size, density,... 相似文献
5.
Jina Ryu Mats Brittberg Bomi Nam Jinyeong Chae Minju Kim Yhan Colon Iban Martin Magneli Eiji Takahashi Bharti Khurana Charles R. Bragdon 《International journal of molecular sciences》2022,23(5)
Cartilage lesions are difficult to repair due to low vascular distribution and may progress into osteoarthritis. Despite numerous attempts in the past, there is no proven method to regenerate hyaline cartilage. The purpose of this study was to investigate the ability to use a 3D printed biomatrix to repair a critical size femoral chondral defect using a canine weight-bearing model. The biomatrix was comprised of human costal-derived cartilage powder, micronized adipose tissue, and fibrin glue. Bilateral femoral condyle defects were treated on 12 mature beagles staged 12 weeks apart. Four groups, one control and three experimental, were used. Animals were euthanized at 32 weeks to collect samples. Significant differences between control and experimental groups were found in both regeneration pattern and tissue composition. In results, we observed that the experimental group with the treatment with cartilage powder and adipose tissue alleviated the inflammatory response. Moreover, it was found that the MOCART score was higher, and cartilage repair was more organized than in the other groups, suggesting that a combination of cartilage powder and adipose tissue has the potential to repair cartilage with a similarity to normal cartilage. Microscopically, there was a well-defined cartilage-like structure in which the mid junction below the surface layer was surrounded by a matrix composed of collagen type I, II, and proteoglycans. MRI examination revealed significant reduction of the inflammation level and progression of a cartilage-like growth in the experimental group. This canine study suggests a promising new surgical treatment for cartilage lesions. 相似文献
6.
Shyam S. Shukla Alka S. Shukla Kwun-Chi Lee
Tejraj M. Aminabhavi
Ramachandra H. Balundgi 《Journal of hazardous materials》1992,30(3):317-331Solidification/stabilization of toxic pentachlorophenol (PCP) has been studied by using spectroscopic and electrochemical techniques. Portland type I c 相似文献
7.
8.
The use of α, ω‐alkanedisulfonic acid, HO3S(CH2)nSO3H (n = 1, 4, 6 and 12), as a dopant for polyaniline (PANi) was investigated. This series of disulfonic acids with varying chain lengths were synthesized and used in the doping of PANi. The doped polymers showed conductivity in the range 10?2 to 10?1 S cm?1. Thermal studies showed that the doped polymers, depending on the chain length of α,ω‐alkanedisulfonic acid, were stable up to ca 300 °C and the thermal stability decreased with increasing dopant chain length. The thermal stability of α,ω‐alkanedisulfonic acid‐doped PANi was higher than that of alkanesulfonic acid‐doped PANi which typically degrades around 250 °C, suggesting a moderately broader processing window for α,ω‐alkanedisulfonic acid‐doped PANi for blending with other thermoplastics. Copyright © 2012 Society of Chemical Industry 相似文献
9.
10.
One hundred twenty-seven 7-, 9-, and 11-year-old children were presented large or small samples of own-gender enhancing or other-gender enhancing observations. Children read arguments based on the observations, rated argument intelligence, judged the number of other children to whom the observations could be generalized, and provided verbal justifications for their judgments. Own-gender reasoning biases declined with age; these declines were, however, partially accounted for by declines in the strength of self-reported gender affiliations. Reasoning biases-demonstrated by problem-to-problem shifts in reasoning quality-were constrained by sample size, indicating a modest degree of rationality even among 7-year-olds. Specifically, biases co-existed with reasonably extensive generalization from large samples of other-gender evidence. Children were thus able to satisfy motivations for own-gender favoritism and reason in accord with the law of large numbers. Several explanations of the findings-based on changes in the salience of gender, multiple classification skills, and the ability to reason independently from beliefs-are offered. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献