Synthesis,Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Journal of Inorganic and Organometallic Polymers and Materials - In this work, a borosilicate glass sample (5SiO2–45B2O3–20Na2O–25CaO–5Ag2O) was added to nano-sized...     

Thyroid surgery for tumours: the Semon Lecture, presented at the RSM November 1996

1,1,1-Trichloroethane (TRI) is a commonly used industrial solvent with a considerable potential for inhalation abuse. Previous studies in our laboratory and elsewhere have shown that this agent exerts a suppressant effect on operant responding, as well as a number of additional neurobehavioral effects that are similar to those of central nervous system (CNS) depressant drugs. In an effort to provide information relevant to potential mechanisms involved in the behavioral effects and abuse potential of TRI, the present study evaluated the acute effects of this agent on the activity of the hypothalamo-pituitary-adrenal (HPA) axis . Male Sprague-Dawley rats were exposed to 3500 or 5000 ppm TRI by inhalation for 10 or 30 min. Following exposure, plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone and levels of ACTH and corticotropin-releasing factor (CRF) in three brain regions--hypothalamus, hippocampus, and frontal cortex--were determined by selective radioimmunoassays. Levels of TRI in the three brain regions as well as blood were measured by headspace gas chromatography to determine the target tissue concentrations responsible for neuroendocrine changes. Uptake of TRI in blood and all brain regions was very rapid, with stable concentrations apparently achieved within 10 min and maintained for 30 min. During this time course, a significant decrease in plasma corticosterone was produced at 30 min but no significant change in plasma ACTH was observed with 3500 ppm TRI. However, after exposure to 5000 ppm, both plasma ACTH and plasma corticosterone were significantly reduced at 10 and 30 min. ACTH levels in the three brain regions were not significantly changed by TRI, while hypothalamic CRF was significantly increased during exposure to 3500 ppm. However, hypothalamic concentrations of CRF declined following 30 min at 3500 ppm and were not significantly changed by 5000 ppm. This complexity of effects on the regulation of HPA axis activity likely precluded the establishment of consistent relationships between changes in hormonal levels and blood or regional brain concentrations of the inhalant. However, these actions of TRI were strikingly similar to those previously reported for the benzodiazepines.     

Pharmacokinetics and pharmacodynamics of sibrafiban (Ro 48-3657), an orally active IIb/IIIa antagonist, administered alone or in combination with heparin, aspirin, and recombinant tissue-type plasminogen activator in beagles

OBJECTIVE: The study aimed to determine the effectiveness of prophylactic medical intervention in reducing the incidence of cystoid macular edema (CME) and the effectiveness of medical treatment for chronic CME after cataract surgery. DESIGN: The study design was a systematic review and meta-analysis of published reports of randomized clinical trials (RCTs). PARTICIPANTS: Sixteen RCTs involving 2898 eyes examining the effectiveness of medical prophylaxis of CME and 4 RCTs involving 187 eyes testing the effectiveness of medical treatment of chronic CME were used in the study. INTERVENTIONS: Medical prophylaxis of treatment (cyclo-oxygenase inhibitors or corticosteroids) versus control (placebo or active treatment) was performed. MAIN OUTCOME MEASURES: Incidence of angiographically diagnosed CME, incidence of clinically significant CME, and vision were measured. RESULTS: Thirty-six articles reported testing a prophylactic medical intervention for CME after cataract surgery. The incidence of CME varied extensively across studies and was related to the study design used. Summary odds ratios (OR) indicated that prophylactic intervention was effective in reducing the incidence of both angiographic CME (OR = 0.36; 95% confidence interval [CI] = 0.28-0.45) and clinically relevant CME (OR = 0.49; 95% CI = 0.33-0.73). There also was a statistically significant positive effect on improving vision (OR = 1.97; 95% CI = 1.14-3.41). A combination of the results of the four RCTs testing medical therapy for chronic CME indicated a treatment benefit in terms of improving final visual acuity by two or more Snellen lines (OR = 2.67; 95% CI = 1.35-5.30). Assessment of the quality of the 20 RCTs included in the meta-analyses indicated problems in the design, execution, and reporting of a number of trials. CONCLUSION: A combination of the results from RCTs indicates that medical prophylaxis for aphakic and pseudophakic CME and medical treatment for chronic CME are beneficial. Because most of the RCTs performed to date have problems related to quality, a well-designed RCT is needed to confirm this result, using clinical CME and vision as outcomes.     

Majority bargaining for resource division

We address the problem of how a set of agents can decide to share a resource, represented as a unit-sized pie. The pie can be generated by the entire set but also by some of its subsets. We investigate a finite horizon non-cooperative bargaining game, in which the players take it in turns to make proposals on how the resource should for this purpose be allocated, and the other players vote on whether or not to accept the allocation. Voting is modelled as a Bayesian weighted voting game with uncertainty about the players’ weights. The agenda, (i.e., the order in which the players are called to make offers), is defined exogenously. We focus on impatient players with heterogeneous discount factors. In the case of a conflict, (i.e., no agreement by the deadline), no player receives anything. We provide a Bayesian subgame perfect equilibrium for the bargaining game and conduct an ex-ante analysis of the resulting outcome. We show that the equilibrium is unique, computable in polynomial time, results in an instant Pareto optimal outcome, and, under certain conditions provides a foundation for the core and also the nucleolus of the Bayesian voting game. In addition, our analysis leads to insights on how an individual’s bargained share is influenced by his position on the agenda. Finally, we show that, if the conflict point of the bargaining game changes, then the problem of determining the non-cooperative equilibrium becomes NP-hard even under the perfect information assumption. Our research also reveals how this change in conflict point impacts on the above mentioned results.     

Dual Band PIFA MIMO Antenna Design with High Isolation for Mobile and Wireless Applications by Using the Genetics Algorithms and Non-uniform Overlapping Method

Wireless Personal Communications - Due to the development and growth of Internet platforms and web services as communication resources, the competition for the network and its limited resources is...     

An efficient recommender system algorithm using trust data

The Journal of Supercomputing - Smart services are a concept that provides services to the citizens in an efficient manner. The online shopping and recommender system can play an important role for...     

Novel nano polymeric system containing biosynthesized core shell silver/silica nanoparticles for functionalization of cellulosic based material

An innovative strategy for functional finishing of cellulosic based materials is based on the incorporation of a thin layer of surface modifying systems (SMS) in the form of stimuli-sensitive nanogels containing combining metal nanoparticles and silica. The silver–silica core–shell nanoparticles (NPs) were synthesized by simple one pot chemical method. Silica/silver nanoparticles have been synthesized using low concentration of dextran as reducing and stabilizing agent and using ascorbic acid as antioxidant agent. The core–shell NPs were characterized for their structural, morphological, compositional and optical behaviour using X-ray diffraction, scanning electron microscopy and energy dispersive X-ray analysis. Stimuli-responsive nanogel was prepared by copolymerization of poly(N-isopropylacrylamide) with pullulan, results in a nanogel that is responsive to both temperature and pH, the nano-particulate hydrogel of poly-NiPAAm-pullulan copolymer was synthesized using surfactant-free emulsion method. The prepared nano-particles were used during the preparation steps of the pullulan nanogel to obtain nanogel/combining metal/silica NPs to produce a composite materials. The nanoparticle size in dry (collapsed) state is estimated at 250 nm by SEM and TEM, and effect of temperature and pH on gel-nanoparticles was investigated by DLS and UV–vis spectrophotometry. The incorporation of the nanoparticles to cellulosic material was done by a simple pad dry-cure procedure from aqueous nanoparticle dispersion that contained a cross-linking agent. This application method provided sufficient integrity to coating by maintaining the responsiveness of surface modifying system. The stimuli responsiveness of modified cellulosic materials has been confirmed in terms of regulating its water uptake in dependence of pH and temperature.     

Towards quantum reversible ternary coded decimal adder

Quantum ternary logic is a promising emerging technology for the future quantum computing. Ternary reversible logic circuit design has potential advantages over the binary ones like its logarithmic reduction in the number of qudits. In reversible logic all computations are done in an invertible fashion. In this paper, we propose a new quantum reversible ternary half adder with quantum cost of only 7 and a new quantum ternary full adder with a quantum cost of only 14. We termed it QTFA. Then we propose 3-qutrit parallel adders. Two different structures are suggested: with and without input carry. Next, we propose quantum ternary coded decimal (TCD) detector circuits. Two different approaches are investigated: based on invalid numbers and based on valid numbers. Finally, we propose the quantum realization of TCD adder circuits. Also here, two approaches are discussed. Overall, the proposed reversible ternary full adder is the best between its counterparts comparing the figures of merits. The proposed 3-qutrit parallel adders are compared with the existing designs and the improvements are reported. On the other hand, this paper suggested the quantum reversible TCD adder designs for the first time. All the proposed designs are realized using macro-level ternary Toffoli gates which are built on the top of the ion-trap realizable ternary 1-qutrit gates and 2-qutrit Muthukrishnan–Stroud gates.     

A modular computer vision system for picture segmentation and interpretation

The objective of a computer vision system is to outline the objects in a picture and label them with an appropriate interpretation. This paper proposes a new paradigm for a modular computer vision system which is both data directed and knowledge based. The system consists of three different types of units, two of which are associative data memories implemented as relational databases. The short-term memory (STM) contains the raw color picture data and the most current interpretations and deductions about the original scene. The long-term memory (LTM) contains a detailed model of the scene under consideration. A collection of analysis processors, each of which is specialized for a particular task, can communicate with both of these memories. The information in the LTM remains unchanged during the analysis, while the STM is being continually updated and revised by the appropriate processors. The latter may be conceived of as being activated by certain data conditions in the STM, and using the information in both the LTM and STM to alter the status of the STM.     

Effects of silver nanoparticles on thermal properties of DBSA-doped polyaniline/PVC blends

Dodecylbenzenesulfonic acid (DBSA)-doped polyaniline (PAND) has been synthesized by redoping (PANDR) and aqueous polymerization (PANDA) methods. Silver nanoparticles were incorporated into the PANDR/tetrahydrofuran solution (PANDS) and then mixed with poly (vinyl chloride) (PVC) solution to prepare PANDS/PVC nanocomposites. In the present study, effects of silver nanoparticles on thermal properties of PAND/PVC blends have been investigated by employing thermal gravimetric analysis and heat flow microcalorimetry techniques. From these results it has been observed that the thermal stability of blends have increased by increasing the concentration of PAND in blends and nanocomposites. Addition of silver nanoparticles has suppressed the dehydrochlorination process and evolution/degradation of DBSA in PANDS/PVC nanocomposites. Presence of silver nanoparticles in PAND/PVC nanocomposites has reduced the mobility of PANI chains which in turn inhibited the transfer of free radicals formed during degradation of PAND and PVC through inter-chain reactions; hence, degradation process has been slowed down and thermal stability has been improved. Embedment of silver nanoparticles has reduced thermal weight loss corresponding to polymer degradation step and attains lower heat flow level in inert atmosphere for nanocomposites in contrast to those with no nanoparticles, thereby further improving thermal stability of nanocomposites. The heats of oxidation measured for blends and nanocomposites were independent of PAND/PVC blends composition.