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排序方式: 共有191条查询结果,搜索用时 15 毫秒
1.
Raquel Cano Jos L. Prez Liss Angarita Dvila ngel Ortega Yosselin Gmez Nereida Josefina Valero-Cedeo Heliana Parra Alexander Manzano Teresa Isabel Vliz Castro María P. Díaz Albornoz Gabriel Cano Joselyn Rojas-Quintero Maricarmen Chacín Valmore Bermúdez 《International journal of molecular sciences》2021,22(9)
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required. 相似文献
2.
López-Castejón Maria Luisa Hurtado Maria del Carmen de la Fuente Julia Mena Baltasar Bengoechea Carlos 《Iranian Polymer Journal》2021,30(7):723-735
Iranian Polymer Journal - The present work focuses on the assessment of the ability of porcine plasma protein (PPP) to be electrospun satisfactorily to form fibre mats, and their rheological and... 相似文献
3.
M. Manzano M. Urueña M. Sužnjević E. Calle J. A. Hernández M. Matijasevic 《Multimedia Systems》2014,20(5):451-470
Cloud gaming is a new paradigm that is envisaged to play a pivotal role in the video game industry in forthcoming years. Cloud gaming, or gaming on demand, is a type of online gaming that allows on-demand streaming of game content onto non-specialised devices (e.g. PC, smart TV, etc.). This approach requires no downloads or game installation because the actual game is executed on the game company’s server and is streamed directly to the client. Nonetheless, this revolutionary approach significantly affects the network load generated by online games. As cloud gaming presents new challenges for both network engineers and the research community, both groups need to be fully conversant with these new cloud gaming platforms. The purpose of this paper is to investigate OnLive, one of the most popular cloud gaming platforms. Our key contributions are: (a) a review of the state-of-the-art of cloud gaming; (b) reverse engineering of the OnLive protocol; and (c) a synthetic traffic model for OnLive. 相似文献
4.
Society is now, more than ever, highly dependent on the large-scale networks that underpin its functions. In relatively recent times, significant failures have occurred on large-scale networks that have a considerable impact upon sizable proportions of the world’s inhabitants. The failure of infrastructure has, in turn, begot a subsequent loss of services supported by that network. Consequently, it is now vitally important to evaluate the robustness of such networks in terms of the services supported by the network in question. Evaluating network robustness is integral to service provisioning and thus any network should include explicit indication of the impact upon service performance. Traditionally, network robustness metrics focused solely on topological characteristics, although some new approaches have considered, to a degree, the services supported by such networks. Several shortcomings of these new metrics have been identified. With the purpose of solving the drawbacks of these metrics, this paper presents a new measure called endurance, which quantifies the level of robustness supported by a specific topology under different types of multiple failure scenarios, giving higher importance to perturbations affecting low percentages of elements of a network. In this paper, endurance of six synthetic complex networks is computed for a range of defined multiple failure scenarios, taking into account the connection requests that cannot be satisfied. It is demonstrated that our proposal is able to quantify the robustness of a network under given multiple failure scenarios. Finally, results show that different types of networks react differently depending on the type of multiple failure. 相似文献
5.
Antonio Fernández Anta José Luis López-Presa M. Araceli Lorenzo Pilar Manzano Juan Martinez-Romo Alberto Mozo Christopher Thraves 《Theory of Computing Systems》2011,48(1):1-22
In this paper we generalize the Continuous Adversarial Queuing Theory (CAQT) model (Blesa et al. in MFCS, Lecture Notes in
Computer Science, vol. 3618, pp. 144–155, 2005) by considering the possibility that the router clocks in the network are not synchronized. We name the new model Non Synchronized
CAQT (NSCAQT). Clearly, this new extension to the model only affects those scheduling policies that use some form of timing.
In a first approach we consider the case in which although not synchronized, all clocks run at the same speed, maintaining
constant differences. In this case we show that all universally stable policies in CAQT that use the injection time and the
remaining path to schedule packets remain universally stable. These policies include, for instance, Shortest in System (SIS)
and Longest in System (LIS). Then, we study the case in which clock differences can vary over time, but the maximum difference
is bounded. In this model we show the universal stability of two families of policies related to SIS and LIS respectively
(the priority of a packet in these policies depends on the arrival time and a function of the path traversed). The bounds
we obtain in this case depend on the maximum difference between clocks. This is a necessary requirement, since we also show
that LIS is not universally stable in systems without bounded clock difference. We then present a new policy that we call
Longest in Queues (LIQ), which gives priority to the packet that has been waiting the longest in edge queues. This policy
is universally stable and, if clocks maintain constant differences, the bounds we prove do not depend on them. To finish,
we provide with simulation results that compare the behavior of some of these policies in a network with stochastic injection
of packets. 相似文献
6.
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8.
Although beer is a relatively safe product, growth of spoilage microorganisms can cause economic damage. The most effective way to prevent the spoilage of beer is to control contamination with adequate cleaning and sanitation. The aim of this work was to evaluate the microbial flora present both before and after a specific hygiene process was implemented during a brewpub's craft beer production. Various selective and differential culture media methods for the enumeration of beer‐spoilage species are available, but they are time consuming compared to modern techniques. The utilisation of accurate molecular methods, added to the routine microbiological analyses, allowed for the fast identification of common environmental contaminants of beer. A poor sanitation plan by the brewer resulted in microbial contamination of the brewpub. This result demonstrates the importance of good sanitation to avoid the presence of undesirable microorganisms in the product. A cleaning‐in‐place (CIP) method, in operation in many small breweries, could be utilised to prevent the occurrence of such brewery and beer microbial contaminants. In small breweries, the simplest CIP units consist of a single tank and a portable pump. This method requires no additional equipment besides a spraying ball, which is usually included in the design of most tanks. 相似文献
9.
Miguel Manzano Antonio J. Salinas Francisco J. Gil María Vallet-Regí 《Journal of materials science. Materials in medicine》2009,20(9):1795-1801
In this paper, different organic–inorganic hybrid materials based in the CaO–SiO2–poly(dimethyl siloxane) PDMS system have been characterised by means of nanoindentation and their static mechanical properties
(Young’s modulus, and hardness) have been investigated. These mechanical properties have been discussed in relation to the
chemical composition and structure of the different hybrid materials. Besides, the mechanical behaviour of hybrid materials
is visco-elastic and it therefore presents phenomena of creep that will be influenced by the temperature of the mechanical
test; undoubtedly, a temperature of 37°C accelerates the processes of creep. 相似文献
10.
Elena Fernández Ángel Alegría Susana Delgado Baltasar Mayo 《International Dairy Journal》2010,20(3):142-148
A series of Lactococcus garvieae strains isolated as the majority population of a Spanish traditional, starter-free cheese made from raw milk were phenotypically and genotypically characterised to address their biochemical potential, safety requirements, and technological properties. As expected, all L. garvieae cheese strains fermented lactose but grew slowly in UHT-treated milk. Enzymatic activities of L. garvieae were similar to those of Lactococcus lactis, although higher esterase and lipase activities were recorded for L. garvieae strains. Profiles of the volatile compounds produced from milk by L. garvieae and L. lactis strains were also comparable. L. garvieae strains did not produce haemolysin, gelatinase and the biogenic amines tyramine and histamine. Five L. garvieae stains showed tetracycline resistance encoded by a tet(M) gene. The use of L. garvieae strains as starter or adjunct cultures might be recommended for certain cheese types, provided that the safety of the strains has been demonstrated. 相似文献