The low overall survival rate of patients with pancreatic cancer has driven research to seek a new therapeutic protocol. Radiotherapy (RT) is frequently an option in the neoadjuvant or palliative settings for pancreatic cancer treatment. This study explored the effect of RT protocols on the tumor microenvironment (TME) and their consequent impact on anti-programmed cell death ligand-1 (PD-L1) therapy. Using a murine orthotopic pancreatic tumor model, UN-KC-6141, RT-disturbed TME was examined by immunohistochemical staining. The results showed that ablative RT is more effective than fractionated RT at recruiting T cells. On the other hand, fractionated RT induces more myeloid-derived suppressor cell infiltration than ablative RT. The RT-disturbed TME presents a higher perfusion rate per vessel. The increase in vessel perfusion is associated with a higher amount of anti-PD-L1 antibody being delivered to the tumor. Animal survival is increased by anti-PD-L1 therapy after ablative RT, with 67% of treated animals surviving more than 30 days after tumor inoculation compared to a median survival time of 16.5 days for the control group. Splenocytes isolated from surviving animals were specifically cytotoxic for UN-KC-6141 cells. We conclude that the ablative RT-induced TME is more suited than conventional RT-induced TME to combination therapy with immune checkpoint blockade. 相似文献
Unloaded ring-oscillator simulations, performed with a generic process/physics-based compact model for double-gate (DG) MOSFETs and supplemented with model-predicted on-state currents and gate capacitances for varying supply voltages (VDD), are used to show and explain the speed superiority of extremely scaled DG CMOS over the single-gate (e.g., bulk-Si) counterpart. The DG superiority for unloaded circuits is most substantive for low VDD < ~1 V 相似文献
Based on a high-performance liquid chromatographic pump, we have built a device that allows recirculation of DNA through a 63-microm orifice with ensuing fractionation to a minimum fragment size of approximately 300 base pairs. Residence time of the DNA fragments in the converging flow created by a sudden contraction was found to be sufficiently long to allow extension of the DNA molecules into a highly extended conformation and, hence, breakage to occur at midpoint. In most instances, 30 passages sufficed to obtain a narrow size distribution, with >90% of the fragments lying within a 2-fold size distribution. The shear rate required to achieve breakage was found to be inversely proportional to the 1.0 power of the molecular weight. Compared with a restriction digest, up to 40% of all fragments could be cloned directly, with only marginal improvements in cloning efficiency having been observed upon prior end repair with Klenow, T4 polymerase or T4 polynucleotide kinase. Sequencing revealed a fairly random distribution of the fragments. 相似文献
A criterion for the local taper angle of a low-loss single-mode fibre coupler is established by considering the dominant mode coupling in the coupler taper. Effects due to structure parameters, such as cladding/core thickness ratio, corecladding index difference and core separation, are investigated. It is found that the criterion for the coupler taper can be well approximated by that for the single-mode fibre taper with the same structure parameters. 相似文献
Polycylic aromatic hydrocarbons (PAHs) are listed as carcinogenic and mutagenic priority pollutants, belonging to the environmental endocrine disrupters. Most PAHs in the environment stem from the atmospheric deposition and diesel emission. Consequently, the elimination of PAHs in the off-gases is one of the priority and emerging challenges. Catalytic oxidation has been widely used in the destruction of organic compounds due to its high efficiency (or conversion of reactants), its economic benefits and good applicability.
This study investigates the application of the catalytic oxidation using Pt/γ-Al2O3 catalysts to decompose PAHs and taking naphthalene (the simplest and least toxic PAH) as a target compound. It studies the relationships between conversion, operating parameters and relevant factors such as treatment temperatures, catalyst sizes and space velocities. Also, a related reaction kinetic expression is proposed to provide a simplified expression of the relevant kinetic parameters.
The results indicate that the Pt/γ-Al2O3 catalyst used accelerates the reaction rate of the decomposition of naphthalene and decreases the reaction temperature. A high conversion (over 95%) can be achieved at a moderate reaction temperature of 480 K and space velocity below 35,000 h−1. Non-catalytic (thermal) oxidation achieves the same conversion at a temperature beyond 1000 K. The results also indicate that Rideal–Eley mechanism and Arrhenius equation can be reasonably applied to describe the data by using the pseudo-first-order reaction kinetic equation with activation energy of 149.97 kJ/mol and frequency factor equal to 3.26 × 1017 s−1. 相似文献
We formulate a problem of state information transmission over a state-dependent channel with states known at the transmitter. In particular, we solve a problem of minimizing the mean-squared channel state estimation error E/spl par/S/sup n/ - S/spl circ//sup n//spl par/ for a state-dependent additive Gaussian channel Y/sup n/ = X/sup n/ + S/sup n/ + Z/sup n/ with an independent and identically distributed (i.i.d.) Gaussian state sequence S/sup n/ = (S/sub 1/, ..., S/sub n/) known at the transmitter and an unknown i.i.d. additive Gaussian noise Z/sup n/. We show that a simple technique of direct state amplification (i.e., X/sup n/ = /spl alpha/S/sup n/), where the transmitter uses its entire power budget to amplify the channel state, yields the minimum mean-squared state estimation error. This same channel can also be used to send additional independent information at the expense of a higher channel state estimation error. We characterize the optimal tradeoff between the rate R of the independent information that can be reliably transmitted and the mean-squared state estimation error D. We show that any optimal (R, D) tradeoff pair can be achieved via a simple power-sharing technique, whereby the transmitter power is appropriately allocated between pure information transmission and state amplification. 相似文献
Based on Alamouti code, Lee and Williams proposed two-branch transmit diversity block-coded orthogonal frequency-division multiplexing (TDBC-OFDM) systems, namely, space-time block-coded OFDM (STBC-OFDM) and space-frequency block-coded OFDM (SFBC-OFDM). However, they employed the simple maximum-likelihood (SML) detector, which was designed under the assumption that the channel is static over the duration of a space-time/frequency codeword. Therefore, STBC-OFDM/SFBC-OFDM suffers from the high time/frequency selectivity of the wireless mobile fading channel. In this paper, besides the original SML detector, three detectors proposed by Vielmon et al. are applied to improve the two-branch TDBC-OFDM systems. Additionally, assuming sufficient cyclic prefix, the performances of all systems in spatially uncorrelated time-varying multipath Rayleigh-fading channels are evaluated by theoretical derivation and computer simulation, as well. According to the derived bit-error rate (BER), we further derive the bit-error outage (BEO) to provide a more object judgment on the transmission quality within a fading environment. Numerical results have revealed that significant performance improvement can be achieved even when the systems are operated in highly selective channels. 相似文献