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1.
Sarah Gilgunn Keefe Murphy Henning Stckmann Paul J. Conroy T. Brendan Murphy R. William Watson Richard J. OKennedy Pauline M. Rudd Radka Saldova 《International journal of molecular sciences》2020,21(23)
The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression patterns change with the cellular modifications that accompany the onset of tumorigenesis. The aim of this study was to investigate if differential glycosylation patterns could distinguish between indolent, significant, and aggressive PCa. Whole serum N-glycan profiling was carried out on 117 prostate cancer patients’ serum using our automated, high-throughput analysis platform for glycan-profiling which utilizes ultra-performance liquid chromatography (UPLC) to obtain high resolution separation of N-linked glycans released from the serum glycoproteins. We observed increases in hybrid, oligomannose, and biantennary digalactosylated monosialylated glycans (M5A1G1S1, M8, and A2G2S1), bisecting glycans (A2B, A2(6)BG1) and monoantennary glycans (A1), and decreases in triantennary trigalactosylated trisialylated glycans with and without core fucose (A3G3S3 and FA3G3S3) with PCa progression from indolent through significant and aggressive disease. These changes give us an insight into the disease pathogenesis and identify potential biomarkers for monitoring the PCa progression, however these need further confirmation studies. 相似文献
2.
Effects of breed and age at slaughter on degradation of muscle lipids during processing of dry‐cured hams
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Linda Storrustløkken Hanne Marie Devle Lars Erik Gangsei Carl Fredrik Naess‐Andresen Bjørg Egelandsdal Ole Alvseike Dag Ekeberg 《International Journal of Food Science & Technology》2015,50(8):1933-1943
Hams from Landrace, Duroc and Hampshire pigs slaughtered at ages 6, 7.5 and 9 months were processed to generate Norwegian Parma‐style hams. Lipid contents and the compositions of fatty acid classes (ΣSFA, ΣMUFA, ΣPUFA) within neutral lipids, phospholipids and free fatty acids were determined. Small differences in lipid degradation and composition of the classes were revealed. However, significant sensory differences related to lipids were observed. Breed was more important than age. Dry‐cured Hampshire hams gave a more intense mature odour that may be associated with higher overall lipid degradation. Unexpectedly, these hams also demonstrated high juiciness and tenderness, which could be related to the melting characteristics of the fat. Dry‐cured Duroc hams showed a higher susceptibility towards rancidity, presumably associated with preferential oxidation of n‐6 fatty acids relative to C18:1 n‐9. Dry‐cured Landrace hams showed the lowest juiciness and tenderness, likely due to their lower fat content (marbling). 相似文献
3.
Henning Fernau 《Acta Informatica》1997,34(11):837-857
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6.
In the last decade there was growing interest in strategic management literature about factors that influence a company's ability to use IT. There is general consensus that knowledge and competency are necessary in developing an IT capability, but there is very little understanding of what the necessary competencies are, and how they influence IS usage in different contexts. The small and medium-sized enterprise context is particularly interesting for two reasons: it constitutes a major part of the economy and it has been relatively unsuccessful in exploiting e-business. 相似文献
7.
Henning H. Mikkelsen Jens Oddershede John R. Sabin Ejvind Bonderup 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》1995,100(4):451-457
We derive a Bethe formula for the stopping of swift ions by target molecules oriented with respect to the beam. The theory is characterized by a directional mean excitation energy formed from transition energies and dipole matrix elements. The expression for the mean excitation energy is similar to the one for an isotropic sample but the dipole matrix elements corresponding to the various transition moment directions carry unequal weights which depend on the orientation of the molecule with respect to the beam. For a large class of molecules, the logarithm of the mean excitation energy is linear in sin2 θ, where θ denotes the angle between the beam and the principal molecular axis. We illustrate the properties of the theory in the simple case of a diatomic molecule. 相似文献
8.
Johan P. Hansen Henning Stichtenoth 《Applicable Algebra in Engineering, Communication and Computing》1990,1(1):67-77
We construct a series of algebraic geometric codes using a class of curves which have many rational points. We obtain codes of lengthq
2 over
q
, whereq = 2q
0
2
andq
0 = 2
n
, such that dimension + minimal distance q
2
+ 1 – q
0
(q – 1). The codes are ideals in the group algebra
q
[S], whereS is a Sylow-2-subgroup of orderq
2 of the Suzuki-group of orderq
2
(q
2
+ 1)(q – 1). The curves used for construction have in relation to their genera the maximal number of
GF
q
-rational points. This maximal number is determined by the explicit formulas of Weil and is effectively smaller than the Hasse—Weil bound.Supported by Deutsche Forschungsgemeinschaft while visiting Essen University 相似文献
9.
Werner Strohmaier Henning Klostermeyer Paul Deuritz Erich Windhab 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1992,194(6):531-535
Summary Current texture-measuring instruments and a recently developed measuring method (two-dimensional measuring of the force necessary to spread a sample) were compared in measuring the spreadability of processed cheese. How far subjective assessment by a qualified panel correlates with the instrumental results in determining spreadability and firmness was also investigated. Samples of processed cheese with various consistencies were measured by an Universal testing machine, a buttermeasuring instrument (DIN 10331), a rotational-type rheometer (oscillation mode) and a two-dimensional force measuring instrument. The evaluation of the results shows that an oscillating rheometer is most suitable to measure the spreadability of processed cheese; the correlation coefficient (r) between the dynamic Weissenberg number, calculated from parameters of the rheometer, and the subjective judgement by the panel wasr=0.91. For the determination of firmness the two-dimensional force measuring instrument is most suitable. The correlation coefficient between the parameter tangential energy (S
t) and the sensorially evaluated firmness wasr=0.95.
Vergleich verschiedener Bestimmungsmethoden für die Streichfähigkeit und Festigkeit von Schmelzkäse
Zusammenfassung Verschiedene gebräuchliche Meßinstrumente und ein neu entwickeltes Gerät zur zweidimensionalen Messung der Kräfte, die zum Ausstreichen einer Probe erforderlich sind, wurden vergleichend zur Charakterisierung der Streichfähigkeit von Schmelzkäse erprobt. Dabei wurde auch geprüft, inwieweit die subjektiven Beurteilungen eines qualifizierten Prüferpanels mit den Meßwerten für Streichfähigkeit und Festigkeit korrelierten. Gemessen wurde mit einer Universalprüfmaschine, dem Butterprüfgerät (DIN 10331), einem Rotationsrheometer und mit dem zweidimensional registrierenden Kraftmeßgerät. Dabei zeigte sich, daß das Rheometer im oscillierenden Modus die Streichfähigkeit am besten zu charakterisieren vermag. Die Korrelation zwischen den Rheometerwerten, berechnet als dynamische Weissenbergzahl, und den sensorisch ermittelten Werten für die Streichfähigkeit betrugr=0,91. Zur Bestimmung der Festigkeit ist das zweidimensional registrierende Kraftmeßgerät am besten geeignet, was sich in einem Korrelationskoeffizienten vonr=0,95 zwischen dem ParameterS t und den im Sensoriktest ermittelten Werten für dieFestigkeit ausdrückt.相似文献
10.
TIBER II is designed to be a minimum size and cost candidate for an international Engineering Test Reactor. High-current density Nb3Sn superconducting magnets with radiation-tolerant polymide insulation is combined with a minimum thickness tungsten inbored shield and a common, external vacuum boundary to minimize the inner radial build of the tokamak core. This results in a major radius of 3 m, compared to 5 m for previous ETR designs such as INTOR, with correspondingly lower costs expected. Cyclic stress fatigue limits the number of pulses so that steady-state current drive, based on a combination of neutral beams, lower hybrid and ECH, is designed to achieve reactor-relevant nuclear testing conditions (Fluence 3MW yr/m2, rwall > 1 MW/m2 in steady state).This report is abstracted from a more complete information document UCID-20863 with numerous authors. See Ref. l for complete credits. 相似文献