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Matthias Siemon Olaf Riese Burkhard Forell Dominic Krnung Walter Klein‐Heßling 《火与材料》2019,43(5):497-513
In the context of industrial buildings and power plants, electrical installations and cable trays represent a main fuel load and a potential initial fire source due to possible short circuits or comparable malfunction. Furthermore, a fire can spread from one tray to additional trays mounted above and/or horizontally on one tray. Because of the high significance of cable fires, several research projects have been carried out, investigating the fire behaviour of cables from small‐scale tests, eg, the cone calorimeter, up to large‐scale tests, analysing complete cable tray constructions. The goal of the work presented in this paper is the extension of the knowledge regarding the influence of geometrical parameters like the packing density and tray distance on the burning behaviour and fire spread of cable tray installations. The results are considered, together with test results from the literature, to quantify the main physical parameters describing the burning behaviour. In a next step, the general applicability of these parameters as input data for the parametrization of the source term of numerical simulations is shown. The test results show that the burning behaviour and the fire spreading highly depend on the cable arrangement of the cables on the cable tray, in combination with other boundary conditions. By applying the results as input for a fire simulation, the mass loss rate is considered appropriately. 相似文献
3.
Resilient optical networks are predominately designed to protect against single failures of fiber links. But in larger networks, operators also see dual failures. As the capacity was planned for single failures, disconnections can occur by dual failures even if enough topological connectivity is provided. In our approach the design of the network minimizes the average loss caused by dual failures, while single failures are still fully survived. High dual failure restorability is the primary aim, capacity is optimized in a second step. For WDM networks with full wavelength conversion, we formulate mixed integer linear programming models for dedicated path protection, shared (backup) path protection, and path rerouting with and without stub-release. For larger problem instances in path rerouting, we propose two heuristics. Computational results indicate that the connectivity is of much more importance for high restorability values than the overall protection capacity. Shared protection has similar restorability levels as dedicated protection while the capacity is comparable to rerouting. Rerouting surpasses the protection mechanisms in restorability and comes close to 100% dual failure survivability. Compared to single failure planning, both shared path protection and rerouting need significantly more capacity in dual failure planning. 相似文献
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Gradient-corrected density functional theory was used to investigate the adsorption of H2S on Pd(1 1 1) surface. Molecular adsorption was found to be stable with H2S binding preferentially at top sites. In addition, the adsorption of other S moieties (SH and S) was investigated. SH and S were found to be preferentially bind at the bridge and fcc sites, respectively. The reaction pathways and energy profiles for H2S decomposition giving rise to adsorbed S and H were determined. Both H2S(ad) → SH(ad) + H(ad) and SH(ad) → S(ad) + H(ad) reactions were found to have low barriers and high exothermicities. This reveals that the decomposition of H2S on Pd(1 1 1) surface is a facile process. 相似文献
7.
Integrated Microfluidic CustomArray Device for Bacterial Genotyping and Identification 总被引:2,自引:0,他引:2
8.
Daniel Pak-Kong Lun Tak-Wai Shen Tai-Chiu Hsung Dominic K.C. Ho 《Digital Signal Processing》2012,22(6):1161-1173
A reliable speech presence probability (SPP) estimator is important to many frequency domain speech enhancement algorithms. It is known that a good estimate of SPP can be obtained by having a smooth a-posteriori signal to noise ratio (SNR) function, which can be achieved by reducing the noise variance when estimating the speech power spectrum. Recently, the wavelet denoising with multitaper spectrum (MTS) estimation technique was suggested for such purpose. However, traditional approaches directly make use of the wavelet shrinkage denoiser which has not been fully optimized for denoising the MTS of noisy speech signals. In this paper, we firstly propose a two-stage wavelet denoising algorithm for estimating the speech power spectrum. First, we apply the wavelet transform to the periodogram of a noisy speech signal. Using the resulting wavelet coefficients, an oracle is developed to indicate the approximate locations of the noise floor in the periodogram. Second, we make use of the oracle developed in stage 1 to selectively remove the wavelet coefficients of the noise floor in the log MTS of the noisy speech. The wavelet coefficients that remained are then used to reconstruct a denoised MTS and in turn generate a smooth a-posteriori SNR function. To adapt to the enhanced a-posteriori SNR function, we further propose a new method to estimate the generalized likelihood ratio (GLR), which is an essential parameter for SPP estimation. Simulation results show that the new SPP estimator outperforms the traditional approaches and enables an improvement in both the quality and intelligibility of the enhanced speeches. 相似文献
9.
Peter K. Windsor Stephen P. Plassmeyer Dominic S. Mattock Jonathan C. Bradfield Erika Y. Choi Bill R. Miller III Byung Hee Han 《International journal of molecular sciences》2021,22(6)
Deposition of amyloid β (Aβ) fibrils in the brain is a key pathologic hallmark of Alzheimer’s disease. A class of polyphenolic biflavonoids is known to have anti-amyloidogenic effects by inhibiting aggregation of Aβ and promoting disaggregation of Aβ fibrils. In the present study, we further sought to investigate the structural basis of the Aβ disaggregating activity of biflavonoids and their interactions at the atomic level. A thioflavin T (ThT) fluorescence assay revealed that amentoflavone-type biflavonoids promote disaggregation of Aβ fibrils with varying potency due to specific structural differences. The computational analysis herein provides the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferentially bind to the aromatic-rich, partially ordered N-termini of Aβ fibril via the π–π interactions. Moreover, docking scores correlate well with the ThT EC50 values. Molecular dynamic simulations revealed that biflavonoids decrease the content of β-sheet in Aβ fibril in a structure-dependent manner. Hydrogen bond analysis further supported that the substitution of hydroxyl groups capable of hydrogen bond formation at two positions on the biflavonoid scaffold leads to significantly disaggregation of Aβ fibrils. Taken together, our data indicate that biflavonoids promote disaggregation of Aβ fibrils due to their ability to disrupt the fibril structure, suggesting biflavonoids as a lead class of compounds to develop a therapeutic agent for Alzheimer’s disease. 相似文献
10.
Pauline V. Marck Marco T. Pessoa Yunhui Xu Laura C. Kutz Dominic M. Collins Yanling Yan Cierra King Xiaoliang Wang Qiming Duan Liquan Cai Jeffrey X. Xie Jerry B. Lingrel Zijian Xie Jiang Tian Sandrine V. Pierre 《International journal of molecular sciences》2021,22(7)
The Na/K-ATPase is the specific receptor for cardiotonic steroids (CTS) such as ouabain and digoxin. At pharmacological concentrations used in the treatment of cardiac conditions, CTS inhibit the ion-pumping function of Na/K-ATPase. At much lower concentrations, in the range of those reported for endogenous CTS in the blood, they stimulate hypertrophic growth of cultured cardiac myocytes through initiation of a Na/K-ATPase-mediated and reactive oxygen species (ROS)-dependent signaling. To examine a possible effect of endogenous concentrations of CTS on cardiac structure and function in vivo, we compared mice expressing the naturally resistant Na/K-ATPase α1 and age-matched mice genetically engineered to express a mutated Na/K-ATPase α1 with high affinity for CTS. In this model, total cardiac Na/K-ATPase activity, α1, α2, and β1 protein content remained unchanged, and the cardiac Na/K-ATPase dose–response curve to ouabain shifted to the left as expected. In males aged 3–6 months, increased α1 sensitivity to CTS resulted in a significant increase in cardiac carbonylated protein content, suggesting that ROS production was elevated. A moderate but significant increase of about 15% of the heart-weight-to-tibia-length ratio accompanied by an increase in the myocyte cross-sectional area was detected. Echocardiographic analyses did not reveal any change in cardiac function, and there was no fibrosis or re-expression of the fetal gene program. RNA sequencing analysis indicated that pathways related to energy metabolism were upregulated, while those related to extracellular matrix organization were downregulated. Consistent with a functional role of the latter, an angiotensin-II challenge that triggered fibrosis in the α1r/rα2s/s mouse failed to do so in the α1s/sα2s/s. Taken together, these results are indicative of a link between circulating CTS, Na/K-ATPase α1, ROS, and physiological cardiac hypertrophy in mice under baseline laboratory conditions. 相似文献