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2.
Direction-dependent scaling, shaping, and rotation of Gaussian basis functions are introduced for maximal trend sensing with minimal parameter representations for input output approximation. It is shown that shaping and rotation of the radial basis functions helps in reducing the total number of function units required to approximate any given input-output data, while improving accuracy. Several alternate formulations that enforce minimal parameterization of the most general radial basis functions are presented. A novel "directed graph" based algorithm is introduced to facilitate intelligent direction based learning and adaptation of the parameters appearing in the radial basis function network. Further, a parameter estimation algorithm is incorporated to establish starting estimates for the model parameters using multiple windows of the input-output data. The efficacy of direction-dependent shaping and rotation in function approximation is evaluated by modifying the minimal resource allocating network and considering different test examples. The examples are drawn from recent literature to benchmark the new algorithm versus existing methods 相似文献
3.
PS Frenette S Subbarao IB Mazo UH von Andrian DD Wagner 《Canadian Metallurgical Quarterly》1998,95(24):14423-14428
The adhesive mechanisms allowing hematopoietic progenitor cells (HPC) homing to the bone marrow (BM) after BM transplantation are poorly understood. We investigated the role of endothelial selectins and vascular cell adhesion molecule-1 (VCAM-1) in this process. Lethally irradiated recipient mice deficient in both P-and E-selectins (P/E-/-), reconstituted with minimal numbers (=5 x 10(4)) of wild-type BM cells, poorly survived the procedure compared with wild-type recipients. Excess mortality in P/E-/- mice, after a lethal dose of irradiation, was likely caused by a defect of HPC homing. Indeed, we observed that the recruitment of HPC to the BM was reduced in P/E-/- animals, either splenectomized or spleen-intact. Homing into the BM of P/E-/- recipient mice was further compromised when a function-blocking VCAM-1 antibody was administered. Circulating HPC, 14 hr after transplantation, were greatly increased in P/E-/- mice treated with anti-VCAM-1 compared with P/E-/- mice treated with just IgG or wild-type mice treated with either anti-VCAM-1 or IgG. Our results indicate that endothelial selectins play an important role in HPC homing to the BM. Optimal recruitment of HPC after lethal doses of irradiation requires the combined action of both selectins and VCAM-1 expressed on endothelium of the BM. 相似文献
4.
James L. Julson Gurram Subbarao D. D. Stokke Heath H. Gieselman K. Muthukumarappan 《应用聚合物科学杂志》2004,93(5):2484-2493
Plastic fiber composites, consisting of polypropylene (PP) or polyethylene (PE), and pinewood, big blue stem (BBS), soybean hulls, or distillers dried grain and solubles (DDGS), were prepared by extrusion. Young's modulus, tensile and flexural strengths, melt flow, shrinkage, and impact energy, with respect to the type, amount, and size of fiber on composites, were evaluated. Young's moduli under tensile load of wood, BBS, and soybean‐hull fiber composites, compared with those of pure plastic controls, were either comparable or higher. Tensile strength significantly decreased for all the PP/fiber composites when compared with that of the control. Strength of BBS fiber composites was higher than or comparable to that of wood. When natural fibers were added there was a significant decrease in the melt flow index for both plastic/fiber composites. There was no significant difference in the shrinkage of all fiber/plastic composites compared to that of controls. BBS/PE plastic composites resulted in higher notched impact strength than that of wood or soybean‐hull fiber composites. There was significant reduction in the unnotched impact strength compared to that of controls. BBS has the potential to be used as reinforcing materials for low‐cost composites. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 2484–2493, 2004 相似文献
5.
Preparation and surface- active properties of polyoxyethylene-glycol (600) monoesters of fatty acids
T. Chandrasekhara Rao Y. Sita Rama Sastry R. Subbarao Gollamudi Lakshminarayana 《Journal of the American Oil Chemists' Society》1977,54(1):15-16
Polyoxyethyleneglycol (PEG-600) monoesters of undecylenic, lauric, myristic, palmitic, stearic, oleic, ricinoleic and 12-hydroxystearic
acids were prepared in 80-85% yield by reacting PEG with boric acid, esterifying the resultant borate with fatty acid, and
selectively hydrolyzing the borate ester; their surface active properties were evaluated. Increase in acyl chain length increased
the surface tension. The presence of a double bond or hydroxyl group in C18 series improved the wetting and emulsifying proper-ties. Unsaturation in the fatty acid chain reduced the foaming power. 相似文献
6.
Some of the current best conformant probabilistic planners focus on finding a fixed length plan with maximal probability. While these approaches can find optimal solutions, they often do not scale for large problems or plan lengths. As has been shown in classical planning, heuristic search outperforms bounded length search (especially when an appropriate plan length is not given a priori). The problem with applying heuristic search in probabilistic planning is that effective heuristics are as yet lacking.In this work, we apply heuristic search to conformant probabilistic planning by adapting planning graph heuristics developed for non-deterministic planning. We evaluate a straight-forward application of these planning graph techniques, which amounts to exactly computing a distribution over many relaxed planning graphs (one planning graph for each joint outcome of uncertain actions at each time step). Computing this distribution is costly, so we apply Sequential Monte Carlo (SMC) to approximate it. One important issue that we explore in this work is how to automatically determine the number of samples required for effective heuristic computation. We empirically demonstrate on several domains how our efficient, but sometimes suboptimal, approach enables our planner to solve much larger problems than an existing optimal bounded length probabilistic planner and still find reasonable quality solutions. 相似文献
7.
8.
Ravi Gummadi Anupam Khulbe Aravind Kalavagattu Sanil Salvi Subbarao Kambhampati 《Journal of Intelligent Information Systems》2012,38(3):575-599
Many web databases can be seen as providing partial and overlapping information about entities in the world. To answer queries effectively, we need to integrate the information about the individual entities that are fragmented over multiple sources. At first blush this is just the inverse of traditional database normalization problem—rather than go from a universal relation to normalized tables, we want to reconstruct the universal relation given the tables (sources). The standard way of reconstructing the entities will involve joining the tables. Unfortunately, because of the autonomous and decentralized way in which the sources are populated, they often do not have Primary Key–Foreign Key relations. While tables may share attributes, naive joins over these shared attributes can result in reconstruction of many spurious entities thus seriously compromising precision. Our system, SmartInt is aimed at addressing the problem of data integration in such scenarios. Given a query, our system uses the Approximate Functional Dependencies (AFDs) to piece together a tree of relevant tables to answer it. The result tuples produced by our system are able to strike a favorable balance between precision and recall. 相似文献
9.
Chen Guang Yu Vimala Bondada Hina Iqbal Kate L. Moore John C. Gensel Subbarao Bondada James W. Geddes 《International journal of molecular sciences》2022,23(1)
Microglia/astrocyte and B cell neuroimmune responses are major contributors to the neurological deficits after traumatic spinal cord injury (SCI). Bruton tyrosine kinase (BTK) activation mechanistically links these neuroimmune mechanisms. Our objective is to use Ibrutinib, an FDA-approved BTK inhibitor, to inhibit the neuroimmune cascade thereby improving locomotor recovery after SCI. Rat models of contusive SCI, Western blot, immunofluorescence staining imaging, flow cytometry analysis, histological staining, and behavioral assessment were used to evaluate BTK activity, neuroimmune cascades, and functional outcomes. Both BTK expression and phosphorylation were increased at the lesion site at 2, 7, 14, and 28 days after SCI. Ibrutinib treatment (6 mg/kg/day, IP, starting 3 h post-injury for 7 or 14 days) reduced BTK activation and total BTK levels, attenuated the injury-induced elevations in Iba1, GFAP, CD138, and IgG at 7 or 14 days post-injury without reduction in CD45RA B cells, improved locomotor function (BBB scores), and resulted in a significant reduction in lesion volume and significant improvement in tissue-sparing 11 weeks post-injury. These results indicate that Ibrutinib exhibits neuroprotective effects by blocking excessive neuroimmune responses through BTK-mediated microglia/astroglial activation and B cell/antibody response in rat models of SCI. These data identify BTK as a potential therapeutic target for SCI. 相似文献
10.
G. Venkateswara Rao R. Subbarao K. T. Achaya 《Journal of the American Oil Chemists' Society》1970,47(8):292-294
Hydroxylation of safflower and linseed oils by routes involving halogen compounds is described. A product containing 20.5%
Br was obtained by treatment of safflower oil in CCl4 solution with N-bromosuccinimide (NBS) in presence of benzoyl peroxide and UV illumination. Bromine was totally removed using
Ag2O in 50% dioxan; the resulting hydroxyl value (HV) was only 100, against an expected HV of 180, perhaps because of dehydration
and ether formation. Using other silver salts, bromine replacement with hydroxyl was always incomplete. Such residual bromine
was totally replaced by hydrogen, without altering other characteristics, by treatment of the product with zinc amalgam in
acetic acid. Linseed oil by similar NBS bromination (Br 22.2%) and Ag2O treatment gave a product with Br 2.9%, HV 74, conj. diene 15% and conj. triene 4%. Halogenreplacement difficulties also
attended the hydrobromination of these oils at the double bonds, followed by hydroxylation. Addition of hypochlorous or hypobromous
acid to safflower oil, followed by total replacement of halogen with hydrogen using zinc amalgam, yielded products of HV 75
and 83 respectively. The degree of hydroxylation was only half of that expected from the loss of unsaturation. 相似文献