Diagnostic focus on the child with myoclonic seizures in isolation or associated with other types of seizures

Myoclonus may be observed in children with mild or severe epileptic syndromes. Both types are seen at characteristic ages, together with other factors: aetiology, family history, hereditary pattern, effect on psychomotor development and EEG-EMG findings. In children with progressive or degenerative encephalopathies and myoclonus, better known as progressive myoclonic epilepsy, there are also specific clinical data, together with biological and genetic markers which permit identification. The most specific clinical characteristics of each of these clinical pictures are described, as are the complementary tests which permit confirmation of these diagnoses.     

An optimization algorithm for multimodal functions inspired by collective animal behavior

Interest in multimodal function optimization is expanding rapidly as real-world optimization problems often demand locating multiple optima within a search space. This article presents a new multimodal optimization algorithm named as the collective animal behavior. Animal groups, such as schools of fish, flocks of birds, swarms of locusts, and herds of wildebeest, exhibit a variety of behaviors including swarming about a food source, milling around a central location, or migrating over large distances in aligned groups. These collective behaviors are often advantageous to groups, allowing them to increase their harvesting efficiency to follow better migration routes, to improve their aerodynamic, and to avoid predation. In the proposed algorithm, searcher agents are a group of animals which interact with each other based on the biologic laws of collective motion. Experimental results demonstrate that the proposed algorithm is capable of finding global and local optima of benchmark multimodal optimization problems with a higher efficiency in comparison with other methods reported in the literature.     

Al–Ti powder produced through mechanical alloying for different times

A powder mixture of aluminum, 10 wt% titanium, and 1.5 wt% of a wax acting as process control agent (PCA), has been attrition-milled for 2–20 h. Titanium powder had been previously ground to a lower particle size to make it similar to the as-received aluminum particle size. The overall aim of this work was to achieve a metastable titanium solution in the aluminum matrix. Changes with milling time of particle size and shape, microstructure, hardness and other powder characteristics have been studied. Given the used experimental-conditions, a process time of 10 h has been selected for the mechanical alloying (MA) of Al–10Ti powder, attaining a compromise between uniform microstructure development and a not so long processing time. At this milling time aluminum dissolves about 9 wt% Ti, increasing its Vickers microhardness (202 VH₂₀) more than 10 times with reference to the starting Al powder (20 VH₂₀). Milled particle size is smaller than the starting one (17 vs. 44 μm). Increasing milling for longer times, up to 20 h, does not produce important changes in powders structure.     

Impact of Zinc on Oxidative Signaling Pathways in the Development of Pulmonary Vasoconstriction Induced by Hypobaric Hypoxia

Hypobaric hypoxia is a condition that occurs at high altitudes (>2500 m) where the partial pressure of gases, particularly oxygen (PO₂), decreases. This condition triggers several physiological and molecular responses. One of the principal responses is pulmonary vascular contraction, which seeks to optimize gas exchange under this condition, known as hypoxic pulmonary vasoconstriction (HPV); however, when this physiological response is exacerbated, it contributes to the development of high-altitude pulmonary hypertension (HAPH). Increased levels of zinc (Zn²⁺) and oxidative stress (known as the “ROS hypothesis”) have been demonstrated in the vasoconstriction process. Therefore, the aim of this review is to determine the relationship between molecular pathways associated with altered Zn²⁺ levels and oxidative stress in HPV in hypobaric hypoxic conditions. The results indicate an increased level of Zn²⁺, which is related to increasing mitochondrial ROS (mtROS), alterations in nitric oxide (NO), metallothionein (MT), zinc-regulated, iron-regulated transporter-like protein (ZIP), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-induced protein kinase C epsilon (PKCε) activation in the development of HPV. In conclusion, there is an association between elevated Zn²⁺ levels and oxidative stress in HPV under different models of hypoxia, which contribute to understanding the molecular mechanism involved in HPV to prevent the development of HAPH.     

Protein Kinases and Parkinson’s Disease

Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson’s disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson’s disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson’s disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules.     

Effects of Si addition on the microstructure and the hydrogen storage properties of Ti26.5V45Fe8.5Cr20Ce0.5 BCC solid solution alloys

The microstructure and the hydrogen storage properties of Ti_26.5(V_0.45Fe_0.085)_100−xCr₂₀Ce_0.5Si_x (x = 0 and 1) have been investigated by EPMA, XRD, in situ temperature XRD, neutron diffraction and P-C isotherm. Si addition results in the precipitation of a TiFe₂-type Laves phase and produces chemical heterogeneity in the BCC phase. As a consequence, Si-added alloy exhibits a lower hydrogen capacity and both a higher plateau pressure and slope factor as compared to Si-free alloy. Si enters in both Laves and BCC phases with a higher preference for the former phase. For both alloys, all metal atoms (Ti, V, Fe and Cr) are supposed to be randomly distributed in the 2a sites of the BCC phase and deuterium atoms occupy the 8c sites on fully charged deuterides. Si has no significant influence on the hydrogen occupation. Two hydrides are observed during the desorption process for Ti_26.5(V_0.45Fe_0.085)₁₀₀Cr₂₀Ce_0.5 alloy, a hydrogen rich one with distorted FCC structure (space group: P4/mmm) and a hydrogen poor one with BCT structure (space group: I4/mmm).     

A satellite remote-sensing multi-index approach to discriminate pelagic Sargassum in the waters of the Yucatan Peninsula,Mexico

Recently, the need for quantitative information on the spatiotemporal distribution of floating macroalgae, particularly the two species of genus Sargassum, has grown because of blooms of these species in the Gulf of Mexico and Caribbean Sea. Remote sensing is one of the most frequently used tools to assess pelagic Sargassum distribution. The purpose of this study was to implement a methodological approach to detect floating algae in an efficient and replicable manner at a moderate cost. We analyzed Landsat 8 imagery, from which we calculated four vegetation indices and one floating-algae index to implement a supervised classification, together with the bands 2 and 5, using the Random Forest algorithm. The analysis was performed monthly from 2014 to 2015 for the northeastern Yucatan Peninsula, Mexico, with a total of 91 analyzed images. The quantitative performance metrics of the classifier (overall, Kappa and Tau) were greater than 80%, whereas bands 2 and 5 as well as the atmospherically resistant vegetation index made the greatest contributions to the classifications. During summer 2015, more than 4,000 ha of Sargassum coverage per image were observed, which was substantially greater than that over the rest of the period. This approach constitutes a transferable alternative for the systematic detection of Sargassum, which enables a quantitative semi-automated time series comparison.     

Influence of risk factors and pharmacological treatment on mortality in patients with essential hypertension

BACKGROUND: The V JNC consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality. AIM: To study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patients followed at an hypertension outpatient clinic. PATIENTS AND METHODS: Patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. Causes of death were obtained from hospital records and death certificates. Survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a Cox's proportional hazards model. RESULTS: Three hundred thirty-nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 +/- 4.9 years. Eighty-six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ACE inhibitors. Blood pressure dropped similarly with all medications. During follow up, 79 patients died. Life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. Similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. The proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality. CONCLUSIONS: In this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors.     

Harvester Ants Utilize Cuticular Hydrocarbons in Nestmate Recognition

Cuticular hydrocarbons appear to play a role in ant nestmate recognition, but few studies have tested this hypothesis experimentally with purified hydrocarbon extracts. We exposed captive colonies of the harvester ant Pogonomyrmex barbatus to small glass blocks coated with whole cuticular lipid extracts and the purified hydrocarbon portion of extracts from nestmate and nonnestmate workers. As an estimate of agonistic behavior, we measured the proportion of ants in contact with blocks that flared their mandibles. Blocks coated with cuticular extracts from nonnestmates were contacted by more workers in one of two experiments and elicited higher levels of aggression in both experiments than blocks bearing extracts from nestmates. The cuticular hydrocarbon fraction of extracts alone was sufficient to elicit agonistic behavior toward nonnestmates. The results demonstrate that harvester ants can perceive differences in cuticular hydrocarbon composition, and can use those differences in nestmate recognition.     

Interpersonal victimization patterns and psychopathology among Latino women: Results from the SALAS study.

[Correction Notice: An erratum for this article was reported in Vol 3(1) of Psychological Trauma: Theory, Research, Practice, and Policy (see record 2010-26899-001). There were citation errors in the last sentence of the first column of text on page 9, and a reference was omitted from the reference list. The sentence should have read: “This result is consistent with other work that has found support for the anxious and dissociative reaction associated with trauma among Latinos and how it may relate to “ataque de nervios” (Hinton, Chong, Pollack, Barlow, & McNally, 2008; Lewis-Fernandez et al., 2002; Schechter et al., 2000; Tolin, Robinson, Gaztambide, Horowitz, & Blank, 2007).] [Correction Notice: An erratum for this article was reported in of Psychological Trauma: Theory, Research, Practice, and Policy (see record 2010-26899-001). In the original article there were citation errors in the last sentence of the first column of text on page 9, and a reference was omitted from the reference list. The sentence should have read: “This result is consistent with other work that has found support for the anxious and dissociative reaction associated with trauma among Latinos and how it may relate to “ataque de nervios” (Hinton, Chong, Pollack, Barlow, & McNally, 2008; Lewis-Fernandez et al., 2002; Schechter et al., 2000; Tolin, Robinson, Gaztambide, Horowitz, & Blank, 2007).] Research on the victimization of Latino women and the subsequent psychological impact has been limited by focusing on individual forms of victimization, primarily partner violence or sexual assault. Another deficiency includes mainly using convenience and/or geographically restricted samples, which impacts the generalizability of the results. To overcome these research limitations, the Sexual Assault Among Latinas (SALAS) study aimed to evaluate the broader scope of victimization among Latino women. The study surveyed a national sample of 2,000 Latino women using random digit dial methodology. Women were asked about various forms of victimization in childhood and adulthood including physical assaults, sexual assaults, stalking, threats, and witnessed violence, as well as psychological symptomatology including depression, anxiety, anger, and dissociation. This analysis found that victimized women were more likely to experience some form of polyvictimization and/or revictimization throughout their lives, with only 36% of victimized women experiencing one form of victimization in childhood or adulthood alone. Furthermore, multiple victimization experiences significantly increased the proportion of women who experienced psychological distress symptoms in the clinical range. For almost all evaluated symptoms, the multiple forms of victimization or varying victimization patterns significantly predicted clinical levels of psychological distress over any specific form or single incident of victimization. The results suggest that victimized Latino women experience multiple forms of victimization and that the evaluation of a broader spectrum of victimization better accounts for pathological symptomatology. Clinical implications for Latino women and future research directions are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)