悉尼理工大学工程和计算机系系馆 澳大利亚悉尼

<正>悉尼理工大学工程和计算机系系馆位于市区的显赫地段,旨在重新给大学城市校区注入活力,成为悉尼商务中心南端的门户。建筑本体如同一件雕塑作品,迥然和周围的传统建筑风格相异。建筑地上14层,地下4层,设有先进的演讲厅、学术办公室、会议室、学习和研究实验室、营业咖啡厅、娱乐区、停车场,并在隔壁建筑旁设计自行车停靠处。     

A method for functional magnetic resonance imaging of olfaction

A method for generating olfactory stimuli for humans within a functional magnetic resonance imaging (fMRI) experimental design is described. The system incorporates a nasal-mask in which the change from odorant to no-odorant conditions occurs in less than 500 ms and is not accompanied by visual, auditory, tactile, or thermal cues. The mask provides an ordorant-free environment following prolonged ordorant presence. Specific imaging parameters that are conducive to the study of the human olfactory system are described. In a pilot study performed using these methods, the specific patterns of activation observed converged with published experimental and clinical findings.     

Exclusion of BMP6 as a candidate gene for cleidocranial dysplasia

Cleidocranial dysplasia (CCD) is an autosomal dominant, generalized skeletal dysplasia in humans that has been mapped to the short arm of chromosome 6. We report linkage of a CCD mutation to 6p21 in a large family and exclude the bone morphogenetic protein 6 gene (BMP6) as a candidate for the disease by cytogenetic localization and genetic recombination. CCD was linked with a maximal two-point LOD score of 7.22 with marker D6S452 at theta = 0. One relative with a recombination between D6S451 and D6S459 and another individual with a recombination between D6S465 and CCD places the mutation within a 7 cM region between D6S451 and D6S465 at 6p21. A phage P1 genomic clone spanning most of the BMP6 gene hybridized to chromosome 6 in band region p23-p24 using FISH analysis, placing this gene cytogenetically more distal than the region of linkage for CCD. We derived a new polymorphic marker from this same P1 clone and found recombinations between the marker and CCD in this family. The results confirm the map position of CCD on 6p21, further refine the CCD genetic interval by identifying a recombination between D6S451 and D6S459, and exclude BMP6 as a candidate gene.     

Molecular analysis of cellulose biosynthesis in Arabidopsis

Cellulose, an abundant, crystalline polysaccharide, is central to plant morphogenesis and to many industries. Chemical and ultrastructural analyses together with map-based cloning indicate that the RSW1 locus of Arabidopsis encodes the catalytic subunit of cellulose synthase. The cloned gene complements the rsw1 mutant whose temperature-sensitive allele is changed in one amino acid. The mutant allele causes a specific reduction in cellulose synthesis, accumulation of noncrystalline beta-1,4-glucan, disassembly of cellulose synthase, and widespread morphological abnormalities. Microfibril crystallization may require proper assembly of the RSW1 gene product into synthase complexes whereas glucan biosynthesis per se does not.     

Intelligent scheduling with tabu search: An application to jobs with linear delay penalties and sequence-dependent setup costs and times

In this article we study thetabu search (TS) method in an application for solving an important class of scheduling problems. Tabu search is characterized by integrating artificial intelligence and optimization principles, with particular emphasis on exploiting flexible memory structures, to yield a highly effective solution procedure. We first discuss the problem of minimizing the sum of the setup costs and linear delay penalties when N jobs, arriving at time zero, are to be scheduled for sequential processing on a continuously available machine. A prototype TS method is developed for this problem using the common approach of exchanging the position of two jobs to transform one schedule into another. A more powerful method is then developed that employs insert moves in combination with swap moves to search the solution space. This method and the best parameters found for it during the preliminary experimentation with the prototype procedure are used to obtain solutions to a more complex problem that considers setup times in addition to setup costs. In this case, our procedure succeeded in finding optimal solutions to all problems for which these solutions are known and a better solution to a larger problem for which optimizing procedures exceeded a specified time limit (branch and bound) or reached a memory overflow (branch and bound/dynamic programming) before normal termination. These experiments confirm not only the effectiveness but also the robustness of the TS method, in terms of the solution quality obtained with a common set of parameter choices for two related but different problems.     

ExoPranayama: a biofeedback-driven actuated environment for supporting yoga breathing practices

Both breathing and internal self-awareness are an integral part of any yoga practice. We describe and discuss the development of ExoPranayama, an actuated environment that physically manifests users’ breathing in yoga. Through a series of trials with yoga practitioners and expert teachers, we explore its role in the practice of yoga. Our interview results reveal that biofeedback through the environment supported teaching and improved self-awareness, but it impacted group cohesion. Two practical uses of the technology emerged for supporting breath control in yoga: (1) biofeedback can provide new information about users’ current internal states; (2) machine-driven feedback provides users with a future state or goal and leads to improved cohesiveness.     

Fixed-wavelength operation of a copper-laser-pumped dye laser injection seeded by low-power He-Ne lasers

The design and operating characteristics of a dye laser pumped by a 3-W copper-vapor laser (CVL) and injection seeded by low-power (1-5 mW) He-Ne lasers at 633 nm are reported. An extremely simple optical arrangement is used wherein the output mirror of the He-Ne laser and a third mirror form the dye laser cavity. Laser efficiency in fixed-wavelength operation has been investigated for variable CVL pump power, He-Ne injection power and polarization, and cavity output coupling for a standard Rhodamine 590/Rhodamine 640 dye solution. Over 90% of free-running (unseeded) laser power is obtained in fixed-wavelength (seeded) operation at low CVL pump powers (≤1 W), dropping to approximately 60% at 3-W pump power. Maximum CVL pump to dye laser optical conversion efficiency in narrow-band, fixed-wavelength operation at 633 nm was 12%.     

Scatter search and star-paths: beyond the genetic metaphor

Scatter search and genetic algorithms have originated from somewhat different traditions and perspectives, yet exhibit features that are strongly complementary. Links between the approaches have increased in recent years as variants of genetic algorithms have been introduced that embody themes in closer harmony with those of scatter search. Some researchers are now beginning to take advantage of these connections by identifying additional ways to incorporate elements of scatter search into genetic algorithm approaches. There remain aspects of the scatter approach that have not been exploited in conjunction with genetic algorithms, yet that provide ways to achieve goals that are basic to the genetic algorithm design. Part of the gap in implementing hybrids of these procedures may derive from relying too literally on the genetic metaphor, which in its narrower interpretation does not readily accommodate the strategic elements underlying scatter search. The theme of this paper is to show there are benefits to be gained by going beyond a perspective constrained too tightly by the connotations of the term genetic. We show that the scatter search framework directly leads to processes for combining solutions that exhibit special properties for exploiting combinatorial optimization problems. In the setting of zero-one integer programming, we identify a mapping that gives new ways to create combined solutions, producing constructions calledstar-paths for exploring the zero-one solution space. Star-path trajectories have the special property of lying within regions assured to include optimal solutions. They also can be exploited in association with both cutting plane and extreme point solution approaches. These outcomes motivate a deeper look into current conceptions of appropriate ways to combine solutions, and disclose there are more powerful methods to derive information from these combinations than those traditionally applied.This research is supported in part by the Joint Air Force Office of Scientific Research and Office of Naval Research Contract No. F49620-90-C-0033 at the University of Colorado