全文获取类型
收费全文 | 5947篇 |
免费 | 126篇 |
国内免费 | 11篇 |
专业分类
电工技术 | 290篇 |
综合类 | 3篇 |
化学工业 | 1202篇 |
金属工艺 | 183篇 |
机械仪表 | 117篇 |
建筑科学 | 90篇 |
矿业工程 | 1篇 |
能源动力 | 183篇 |
轻工业 | 404篇 |
水利工程 | 18篇 |
无线电 | 649篇 |
一般工业技术 | 1058篇 |
冶金工业 | 1293篇 |
原子能技术 | 164篇 |
自动化技术 | 429篇 |
出版年
2023年 | 19篇 |
2022年 | 65篇 |
2021年 | 99篇 |
2020年 | 39篇 |
2019年 | 46篇 |
2018年 | 82篇 |
2017年 | 63篇 |
2016年 | 115篇 |
2015年 | 80篇 |
2014年 | 118篇 |
2013年 | 271篇 |
2012年 | 201篇 |
2011年 | 247篇 |
2010年 | 181篇 |
2009年 | 245篇 |
2008年 | 218篇 |
2007年 | 186篇 |
2006年 | 161篇 |
2005年 | 165篇 |
2004年 | 126篇 |
2003年 | 142篇 |
2002年 | 142篇 |
2001年 | 135篇 |
2000年 | 126篇 |
1999年 | 176篇 |
1998年 | 528篇 |
1997年 | 304篇 |
1996年 | 269篇 |
1995年 | 169篇 |
1994年 | 157篇 |
1993年 | 143篇 |
1992年 | 75篇 |
1991年 | 84篇 |
1990年 | 65篇 |
1989年 | 62篇 |
1988年 | 65篇 |
1987年 | 65篇 |
1986年 | 54篇 |
1985年 | 54篇 |
1984年 | 65篇 |
1983年 | 61篇 |
1982年 | 48篇 |
1981年 | 51篇 |
1980年 | 52篇 |
1979年 | 37篇 |
1978年 | 34篇 |
1977年 | 28篇 |
1976年 | 46篇 |
1974年 | 27篇 |
1973年 | 16篇 |
排序方式: 共有6084条查询结果,搜索用时 15 毫秒
1.
Abidur Rahman Makoto Kobayashi Kotaro Sugimoto Yuta Endo Manabu Kojima Shigenori Furukawa Takafumi Watanabe Shu Soeda Yuko Hashimoto Keiya Fujimori Hideki Chiba 《International journal of molecular sciences》2021,22(7)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Methods: We generated a monoclonal Ab (mAb) against human/mouse CLDN12 and verified its specificity. By performing immunohistochemical staining and semiquantification, we evaluated the relationship between CLDN12 expression and clinicopathological parameters in tissues from 138 cases of cervical cancer. Results: Western blot and immunohistochemical analyses revealed that the established mAb selectively recognized the CLDN12 protein. Twenty six of the 138 cases (18.8%) showed low CLDN12 expression, and the disease-specific survival (DSS) and recurrence-free survival rates were significantly decreased compared with those in the high CLDN12 expression group. We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively). Conclusions: It can be concluded that a reduced CLDN12 expression predicts a poor outcome for cervical cancer. The novel anti-CLDN12 mAb could be a valuable tool to evaluate the biological relevance of the CLDN12 expression in diverse cancer types and other diseases. 相似文献
2.
Vancha Harish Effi Haque Magdalena
miech Hiroaki Taniguchi Sarah Jamieson Devesh Tewari Anupam Bishayee 《International journal of molecular sciences》2021,22(9)
Xanthohumol (XH) is an important prenylated flavonoid that is found within the inflorescence of Humulus lupulus L. (Hop plant). XH is an important ingredient in beer and is considered a significant bioactive agent due to its diverse medicinal applications, which include anti-inflammatory, antimicrobial, antioxidant, immunomodulatory, antiviral, antifungal, antigenotoxic, antiangiogenic, and antimalarial effects as well as strong anticancer activity towards various types of cancer cells. XH acts as a wide ranging chemopreventive and anticancer agent, and its isomer, 8-prenylnaringenin, is a phytoestrogen with strong estrogenic activity. The present review focuses on the bioactivity of XH on various types of cancers and its pharmacokinetics. In this paper, we first highlight, in brief, the history and use of hops and then the chemistry and structure–activity relationship of XH. Lastly, we focus on its prominent effects and mechanisms of action on various cancers and its possible use in cancer prevention and treatment. Considering the limited number of available reviews on this subject, our goal is to provide a complete and detailed understanding of the anticancer effects of XH against different cancers. 相似文献
3.
4.
Eicosapentaenoic acid (EPA) production by an oleaginous fungus Mortierella alpina expressing heterologous the Δ17‐desaturase gene under ordinary temperature
下载免费PDF全文
![点击此处可从《European Journal of Lipid Science and Technology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
5.
Hiromichi Ichinose Masanori Taira Sachiko Furuta Hiroaki Katsuki 《Journal of the American Ceramic Society》2003,86(9):1605-1608
Niobium- or vanadium-doped anatase sols were prepared by hydrothermal treatment of 0.1 mol/dm3 peroxotitanium complex aqueous solutions dissolving 0–10 mol% niobium or vanadium at 100°C for 8 h. Niobium-doping caused the increase of lattice constants of anatase and the shape change of anatase crystal from spindle-like to cubic-like structure, but no change of the optical absorbance. Vanadium-doping caused the decrease of lattice constant of c -axis, the miniaturization of anatase crystal and the increase of optical absorbance at the wavelength from 350–700 nm. 相似文献
6.
A comparative study of DPSK and OOK WDM transmission over transoceanic distances and their performance degradations due to nonlinear phase noise 总被引:1,自引:0,他引:1
Mizuochi T. Ishida K. Kobayashi T. Abe J. Kinjo K. Motoshima K. Kasahara K. 《Lightwave Technology, Journal of》2003,21(9):1933-1943
We have compared experimentally the transmission performance of return-to-zero differential phase-shift keying (RZ-DPSK) with RZ-ON-OFF keying (OOK), nonreturn-to-zero differential phase-shift keying (NRZ-DPSK), and NRZ-OOK for 100/spl times/10-Gb/s transmission with a spectral efficiency of 0.22 b/s/Hz over transoceanic distances. The Q degradation of the RZ-DPSK after transmission over 9180 km was 3 dB greater than that of RZ-OOK. The experimental results clearly showed the major cause of degradation for DPSK is not cross-phase modulation but self-phase modulation. The calculated nonlinear phase noise, i.e., the Gordon-Mollenauer effect, agreed with the experimental results. A distributed-Raman-amplifier assisted erbium-doped-fiber-amplified transmission line acted well in reducing the nonlinear phase noise. 相似文献
7.
8.
Sachiyuki Hasegawa Kazuyuki Shimizu Takeshi Kobayashi Masakazu Matsubara 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》1985,35(1):33-42
Repeated batch operation using two fermentors (RBTF) to penicillin fermentation was demonstrated by computer simulation to improve productivity. Three operation modes were compared: chemostat, repeated batch operation using a single fermentor (RBSF) and RBTF; in each case account was made of the lag period before growth. The simulated fermentor performances were assessed on the basis of the penicillin productivity and concentration; the simulation was based on published batch fermentation data. It was shown that RBTF was superior to RBSF and chemostat. The advantage of RBTF increased as the lag period became greater. 相似文献
9.
E Kobayashi Y Yoshida A Fujimura T Yamanaka H Endo T Hamamoto Y Kagawa 《Canadian Metallurgical Quarterly》1997,24(12):1775-1777
We studied the in vivo gene transfusion using a gene gun, formerly used in plants and culture cells. The hand-held type gene gun (Helios Gene Gun System) is simple and convenient for effective gene transfection in living animals. This method has some advantages in that there is no need for use of viral vector, independence on the cell cycle and local inducement of plural genes. There is a great possibility for application to local-regional cancer. 相似文献
10.
BACKGROUND/PURPOSE: Recent reports have identified abnormal innervation of the circular muscle layer involving the fine intramuscular nerve fibers in hypertrophic pyloric stenous (HPS). HPS presenting after 3 months of age is rare. The aim of this study was to determine the distribution pattern of nerve fibers in the smooth muscle layers in HPS and correlate this with age at presentation. METHODS: Full-thickness pyloric muscle biopsy specimens were obtained from eight patients with HPS (five age 3 to 5 weeks, two age 3 months, and one age 7 months) and five controls with normal pylorus (age 5 days to 3 years). All specimens were stained with monoclonal antibody to the neural cell adhesion molecule (NCAM) using immunohistochemistry. RESULTS: There were many NCAM-positive nerve fibers in the circular and longitudinal muscle layers in the controls. No NCAM positive nerve fibers were seen in the circular or longitudinal muscle layers in the five cases of HPS in which the patients were less than 5 weeks old. In the two cases in which the patients were 3 months old, occasional NCAM-positive nerve fibers were seen in the circular layer, and moderate numbers of NCAM positive fibers were seen in the longitudinal muscle layers. Moderate numbers of NCAM-positive nerve fibers in the circular muscle layer and many NCAM positive nerve fibers in the longitudinal muscle layers were identified in the 7-month-old HPS patient. CONCLUSIONS: The data suggest that the pyloric muscle lacks innervation in the young HPS infant. Whereas, at 3 months of age the hypertrophied pyloric muscle is partially innervated, and at 7 months of age the pyloric muscle has practically normal innervation. 相似文献