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Yan Jing Zhu Rongying Wu Fan Zhao Ziyin Ye Huan Hou Mengying Liu Yong Yin Lichen 《Nano Research》2020,13(10):2706-2715
Nano Research - Insufficient intratumoral penetration greatly hurdles the anticancer performance of nanomedicine. To realize highly efficient tumor penetration in a precisely and spatiotemporally... 相似文献
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Wan Huan Wang Hui Scotney Bryan Liu Jun Ng Wing W. Y. 《Multimedia Tools and Applications》2020,79(39-40):29327-29352
Multimedia Tools and Applications - In many real-world classification problems there exist multiple subclasses (or clusters) within a class; in other words, the underlying data distribution is... 相似文献
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土石过水围堰过水期最不利工况及其流量确定 总被引:7,自引:0,他引:7
本文系统分析了影响土石过水围堰溢流工况的主要因素,提出衡量最不利工况的指标和确定员不利流量的方法,为土石过水围堰堰体下游护坡结构及消能防冲设施设计提供了理论依据。通过理论计算结果与模型试验现场观测资料数据对比分析,说明提出的过水期最不利流量判别方法是符合实际情况的。 相似文献
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日产NHR-90W型催化剂失活原因分析 总被引:1,自引:0,他引:1
对日产NHR -90W催化剂在抚顺石化分公司石油二厂 6万t/a石蜡加氢装置运行情况进行了研究 ,证明该催化剂活性较高 ,对原料的适应性也较强。同时 ,对造成催化剂短期内失活的原因进行了分析 ,认为原料中铁离子含量过高是造成催化剂失活的主要原因。对相关装置生产控制提出了建议 相似文献
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Robustness analysis of responses of vibration control structures with uncertain parameters using interval algorithm 总被引:1,自引:0,他引:1
Variations in system parameters due to uncertainties may result in system performance deterioration. Uncertainties in modeling of structures are often considered to ensure that control system is robust with respect to response errors. Hence, the uncertain concept plays an important role in vibration control of the engineering structures. The paper discusses the robustness of responses of vibration control systems with the uncertain parameters. The vibration control problem of an uncertain system is approximated by a deterministic one. The uncertain parameters are described by interval variables. The uncertain state matrix is constructed directly using system physical parameters and avoided to use bounds in Euclidean norm. The feedback gain matrix is determined based on the deterministic systems, and then it is applied to the actual uncertain systems. A method to calculate the upper and lower bounds of responses of the closed-loop system with uncertain parameters is presented. The upper bounds of responses can be used to estimate the robustness of responses of the controlled system with uncertain parameters. Two numerical examples are given to illustrate the applications of the present approach. 相似文献
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An imbalance between helper T cell type 1 (Th1) and helper T cell type 2 (Th2) activation can result in immunodysregulations leading to impaired cell-mediated immunity with an increased incidence of infectious disease or cancer and/or aberrant humoral immunity that may culminate with an autoimmune disease. Mercury, a heavy-metal toxicant, is known to induce renal autoimmunity characterized by a predominant Th2 response. Lead, another metal toxicant, causes enhanced B cell activities and impairs host resistance to several bacterial and viral infections. In addition, Pb was reported to enhance Th2 proliferation and inhibit Th1 proliferation. The differential effects of Pb on Th subset activation have been further investigated. In vitro IL-4 production by a Th2 clone was significantly increased by the addition of PbCl2, whereas IFN gamma production by a Th1 clone was decreased by the addition of PbCl2. When BALB/c mice were subcutaneously exposed to PbCl2, ex vivo Il-4 production by anti-CD3-stimulated splenic T cells was enhanced, but IFN gamma production was inhibited. Additionally, the plasma IL-4 and IgE levels of Pb-exposed mice were increased, and the plasma IFN gamma levels were significantly lowered in the absence of any additional exogenous antigen. In vitro, ex vivo, and in vivo treatment with HgCl2 produced similar findings. This study is the first report of the preferential activation of a Th2 response by Pb in vivo and suggests that PB, like Hg, may induce autoimmune responses by upsetting the balance between Th1- and Th2-like cells, which could enhance production of antibodies to self antigens. 相似文献