Examination of the role of oxygen in the photografting of methacrylic acid on a polyethylene film with a mixed solvent consisting of water and organic solvents

The photografting of methacrylic acid (MAA) on a linear low‐density polyethylene film (thickness = 30 μm) under air and nitrogen atmospheres was investigated at 60°C in mixed solvents consisting of water and an organic solvent, with xanthone as a photoinitiator. The organic solvents used were acetone, methanol, tetrahydrofuran, and dioxane. A maximum percentage of grafting occurred at a certain concentration of the organic solvent in the mixed solvent. This was observed for the systems under both air and nitrogen. The grafting reaction under air exhibited an induction period, but the rate of grafting after the period was greater than that under nitrogen. The formation of poly(ethylene peroxide)s by photoirradiation seemed to be a factor for the accelerated photografting under air. On the basis of attenuated total reflection infrared spectroscopy and scanning electron microscopy of the grafted film, the MAA‐grafted chains of the sample prepared under air tended to penetrate more deeply inside the film than those of the sample prepared under nitrogen. The resulting grafted films exhibited a pH‐responsive character: the grafted films shrank in an acidic medium but swelled in alkaline medium. This was evaluated from measurements of dimensional changes in the grafted films. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 89: 992–998, 2003     

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach

Pharmacophore searches that include anchors, fragments contributing above average to receptor binding, combined with one-step syntheses are a powerful approach for the fast discovery of novel bioactive molecules. Here, we are presenting a pipeline for the rapid and efficient discovery of aspartyl protease inhibitors. First, we hypothesized that hydrazine could be a multi-valent warhead to interact with the active site Asp carboxylic acids. We incorporated the hydrazine anchor in a multicomponent reaction and created a large virtual library of hydrazine derivatives synthetically accessible in one-step. Next, we performed anchor-based pharmacophore screening of the libraries and resynthesized top-ranked compounds. The inhibitory potency of the molecules was finally assessed by an enzyme activity assay and the binding mode confirmed by several soaked crystal structures supporting the validity of the hypothesis and approach. The herein reported pipeline of tools will be of general value for the rapid generation of receptor binders beyond Asp proteases.     

Combination of Hargreaves method and linear regression as a new method to estimate solar radiation in Perlis, Northern Malaysia

The best way to obtain the solar radiation data of a particular place of interest (POI) is to measure at the specific site continuously and accurately over the long term. However, due to financial, maintenance, calibration requirement of the measuring equipment or institutional limitations, these data are absent, incomplete or inaccessible in most areas of the world. Based on meteorological data from Chuping Station, Perlis which is at Northern Malaysia, there were several missing data of solar radiation for the year 2007 and 2008. This paper presents a new method to estimate the solar radiation which is a combination of Hargreaves method and linear regression. Normally, both regression coefficients, a and b of the linear regression are found based on the measured data, but using the proposed method, both regression coefficients based on the Hargreaves method with the correlated parameter, x is the difference of daily temperature. This paper also presents the basic knowledge of Hargreaves method before the proposed method is implemented. As validation, those solar radiation data that are measured by Chuping Station for the year 2006 and by Electrical Energy and Industrial Electronic System (EEIES) Cluster Station for the month of March–June 2011 and their estimated solar radiation data are compared and analyzed using coefficient of residual mass (CRM), root mean squared error (RMSE), Nash–Sutcliffe equation (NSE) and percentage error (e). The statistical analysis of the average monthly measured solar radiation data for the past 26 years (1979–2006) is compared with the estimated solar radiation data for 3 years (2006–2008). The proposed method result shows that the value of CRM is closer to zero which indicates that the proposed method is perfectly estimated, the values of RMSE are low value, this indicates that the method performs well, the value of NSE is closer to 1 which indicates that the estimated solar radiation match perfectly with the measured data taken for the past 26 years, the value of e is closer to zero which indicates that the proposed method is acceptable and applicable.     

A Fully Autonomous Microrobotic Endoscopy System

In this paper, design of an autonomous microrobotic endoscopy system is presented. The proposed microrobotic endoscope is a vision-guided device, developed to facilitate navigation inside a human colon. The design of the entire system is divided into three areas viz. design of a microrobotic carrier, path planning and guidance, and an off-board control system. A microrobotic design based on pneumatic mechanisms to achieve locomotion and steering is explained. General mathematical analysis governing the differential steering of the robotic tip is also described. The path planning of the microrobot is carried out based on the sensory fusion utilising the quantitative parameters from the captured images and the tactile sensors. A real-time image segmentation scheme is described for extracting the lumen from endoscopic images. An off-board control system to control the directional movements of the microrobot is also explained. The proposed endoscopy system was tested with physical models and animal colons and the experimental observations are presented.     

Improved controller for power conditioner using high-temperature superconducting magnetic energy storage (HTS-SMES)

One of the most important functions in a superconducting magnetic energy storage (SMES) system when used for power conditioning, is the ability to charge the super-conducting coil as fast as possible to ensure that it is ready when it is next required. This paper describes a novel controller for a high-temperature SMES (HTS-SMES) that can ensure: 1) fast return of energy to the superconducting coil under constant-current mode and 2) a constant and sinusoidal input supply current irrespective of the varying load demand with and without harmonics. In the new HTS-SMES proposed, two hysteresis controllers are used, one to control the magnitude, phase and the waveform of the ac supply current, and the other is to control a dc chopper to regulate the SMES coil current. The first hysteresis controller ensures that as far as the power utility is concerned, the load appears to the utility system as a constant sinusoidal load with unity power factor irrespective whether the load is distorted or varying in nature. The second hysteresis controller has been designed to regulate the energy in and out of the superconducting coil. A special feature of this controller is its ability to smoothly charge the superconducting coil using constant current charging so that it can be ready for the next discharging operation as soon as possible. Analysis of the circuit operation under hysteresis control is presented in details. Simulation and experimental results are presented demonstrating the feasibility of the proposed power conditioning system.     

采用剪切弯曲三角杆的对称冷弯型钢-混凝土组合梁的大比例试验

对对称冷弯型钢-混凝土组合梁进行静力受弯试验,介绍了基于剪切弯曲杆改进的剪切弯曲三角杆。冷弯型钢构件比热轧构件更薄,不允许焊接栓钉剪力连接件,剪切弯曲三角杆能解决这一问题。将两个冷弯型钢槽的背靠背连接成对称构件,它在静力作用下具有足够的强度和刚度。通过剪切弯曲三角杆的抗剪方程计算的抗弯承载值与试验数据很吻合。     

Large-scale test of symmetric cold-formed steel (CFS)-concrete composite beams with BTTST enhancement

A new connection device, based on bent-up tab shear transfer enhancement called bent-up triangular tab shear transfer (BTTST), has been studied through a symmetric cold-formed steel (CFS)-concrete composite beam subjected to a static bending test. BTTST provides an alternative connector system unique to CFS where CFS sections are usually thinner than hot-rolled sections and welding of headed-stud shear connectors is inapplicable. Coupled with the back-to-back arrangement of two CFS channels where symmetricity of the built-up section is restored, the resulting composite floor system has been proven to possess adequate strength and stiffness properties under static loads. The work has shown that the predicted values of the flexural capacities calculated using a new equation of shear capacity of BTTST agrees reasonably well with the experimental values.     

Locomotion techniques for robotic colonoscopy.

Colonoscopy has become a routine procedure in many hospitals all over the world for colon cancer diagnosis. This review article discusses the work done by researchers in the quest to automate the colonoscopy procedure. In vitro and in vivo experimentation have been carried out to prove the possibilities of a robot crawling along a patient's colon, treating polyps as they are encountered. Locomotion is an essential part of robotic colonoscopy. The robot must be able to propel itself from the anus right up to the cecum without damaging the colon walls. The challenge is to design a robust locomotion technique that is able to advance through the stretchable, slippery, and mobile colon, which is always in its collapsed stage, in three-dimensional orientation. The authors believe that in the future, conventional colonoscopy will be revolutionized, giving way to robotics to assist doctors in colonoscope manipulation and performing therapeutic procedures and leaving doctors to concentrate on the diagnostic aspect of the procedure, which would encourage mass screening as more patients can be evaluated per session.     

The use of experimental design to study the responses of continuous devulcanization processes

This paper presents the use of statistical analysis for studying the responses of two continuous devulcanization processes (of the EPDM roofing sheet and the EPDM profile) in the extruder. The response is represented by the reaction conversion, which is denoted as the relative decrease in crosslink density. Experimental design is considered as a useful tool when the kinetic data for the physical modeling are not available. The models derived show similar tendency of both processes with respect to the temperature and the screw speed. A difference is observed in their responses to the feed rate, which might be the consequence of their different devulcanization rates. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:5028–5038, 2006     

On a simple triangular reissner/mindlin plate element based on incompatible modes and discrete constraints

In this paper the formulation of a new triangular element based on the Reissner/Mindlin plate theory is presented. The element has three nodes and three d.o.f. per node only. It is based on constant bending modes plus incompatible energy orthogonal higher order bending modes. The transverse shear effects are represented using the moment equilibrium and the constitutive equations. Discrete (collocation) shear constraints are considered on each side to relate the kinematical and the independent shear strains. The element has a proper rank, is completely locking free, passes all constant patch-tests exactly. The detailed numerical evaluation shows that the element, called DST-BK, is a robust and high-performance element for thick and thin plates.