Hemodialysis in a patient with severe hemophilia A and factor VIII inhibitor

Hemophilia A is a hereditary X‐linked recessive disease caused by mutations in the gene encoding factor VIII (FVIII), occurring in 1 out of 10,000 persons. Life expectancy and quality of life have dramatically improved recently in patients with hemophilia. Chronic kidney disease and need for renal replacement therapy in these patients are rare. The development of inhibitors to FVIII is the most serious complication of hemophilia and makes treatment of bleeds very challenging. We describe here a 28‐year‐old male patient with severe hemophilia A with presence of factor VIII inhibitor, who had end stage renal disease. Central venous access device was inserted along with infusion of factor eight inhibitor bypass activity before and after the procedure. He is currently on thrice weekly hemodialysis and doing well for 6 months without bleeding episodes. To our knowledge, hemophilia A with factor VIII inhibitor managed with hemodialysis has not been reported so far.     

Sugar industry waste-derived anode for enhanced biohydrogen production from rice mill wastewater using artificial photo-assisted microbial electrolysis cell

Microbial Electrolysis Cell (MEC) is a promising green technology for energy production from wastewater. This study attempts to investigate the biohydrogen production from rice mill wastewater using artificial photo-assisted microbial electrolysis cell (APAMEC) with an inexpensive anode prepared from carbonaceous material disposed by sugar industry. The X-ray diffraction (XRD) and scanning electron microscopic (SEM) analyses confirmed the presence of carbon on the electrode surface. Cyclic Voltammogram analysis indicated that the carbonaceous anode has higher reduction peak at 0.7 V compared to control (plain carbon cloth) electrode. The experimental results showed a maximum hydrogen production of 220 mL on 5th day of fermentation and the production rate observed was 3.6 ± 0.4 mL/l/h. The effect of pH and acid concentration used in the acid hydrolysis of rice mill wastewater and the effect of artificial light on biohydrogen production were investigated. The optimum pH and acid concentration of 6 and 1.5%, respectively, gave better biohydrogen production and COD removal. The results demonstrated that the development of inexpensive anode from the waste disposed by sugar industry would pave the path to scale-up MECs.