Kinetic analysis of plasma VLDL-TG and VLDL-remnant-TG turnover in anesthetized rats

We have estimated the turnover and relative pool sizes of nascent-VLDL-TG and VLDL-remnants-TG in anesthetized rats. [1-¹⁴C]Palmitoyl- and [2-³H]glyceryl-labeled “VLDL”-TG (including nascent VLDL-TG and VLDL-remnants-TG) were prepared by injecting labeled palmitate and glycerol into donor rats. Labeled serum from these rats was then injected intravenously into nembutalized male rats and serial blood samples taken for 30 min. Special care was taken to define any early components in the labeled “VLDL”-TG disappearance curves. In other experiments, the donors were rendered functionally hepatectomized 30 min after injection of³H-glycerol and the endogenous labeled VLDL-TG was allowed to circulate 30–60 min before collection of the TG-labeled VLDL-remnants-containing serum. The latter was injected into 4 recipient nembutalized rats and the remnant-TG-turnover measured by serial sampling as above. In two cases,¹⁴C-“VLDL” and³H-VLDL-remnants were injected as a single bolus into ether-anesthetized rats. Despite its complex composition, “VLDL”-TG in most cases disappeared in a single exponential fashion for 30 min with an average half-life of 5.9 min in nembutalized and 2.8 in ether-anesthetized rats. VLDL-remnants-TG showed a more complex behavior, but contained a major rapid component with a mean t_1/2 of ca. 1.5 min in both groups. The data, analyzed by multicompartmental analysis, were fitted to a simple model in which turnover of a larger nascent VLDL-TG pool with formation of a more rapidly turning over smaller pool of VLDL-remnant-TG is the rate-limiting step in overall TG removal from the d<1.006 fraction of rat serum. The data are consistent with our theoretical prediction that under these conditions the kinetics of the VLDL-remnants cannot be resolved from analysis of the total composite “VLDL” (nascent plus remnant) pool.     

Support vector machine-based classification scheme for myoelectric control applied to upper limb

This paper proposes and evaluates the application of support vector machine (SVM) to classify upper limb motions using myoelectric signals. It explores the optimum configuration of SVM-based myoelectric control, by suggesting an advantageous data segmentation technique, feature set, model selection approach for SVM, and postprocessing methods. This work presents a method to adjust SVM parameters before classification, and examines overlapped segmentation and majority voting as two techniques to improve controller performance. A SVM, as the core of classification in myoelectric control, is compared with two commonly used classifiers: linear discriminant analysis (LDA) and multilayer perceptron (MLP) neural networks. It demonstrates exceptional accuracy, robust performance, and low computational load. The entropy of the output of the classifier is also examined as an online index to evaluate the correctness of classification; this can be used by online training for long-term myoelectric control operations.     

An optimal residency-aware scheduling technique for cluster tools with buffer module

Cluster tools provide a flexible, reconfigurable, and efficient environment for several manufacturing processes (e.g., semiconductor manufacturing). A new timing constraint (distinct from a simple deadline), referred to as residency constraint, puts a timing limit on the time that a wafer can stay in a processing module in a cluster tool. The authors demonstrate that a solution that does not address residency constraints can be found easily. However, when residency constraints are added to the model, the problem becomes complex and a scheduling technique may spend a long time searching for a good solution. Also, in some cases, one may need to decrease throughput to satisfy residency constraints. The authors introduce a new technique to address cluster tool scheduling in the presence of residency constraints. The proposed technique uses a buffer resource for temporarily holding wafers to release other resources such as the robot arm. This resource is usually available in the tool for maintenance reasons. A tradeoff is discussed in using the buffer resource and a scheduling algorithm is presented that will use this resource when it can help to increase throughput under residency constraints. The experiments show that in many cases that are common in semiconductor manufacturing, use of their proposed technique can improve throughput.     

Low threshold and tunable all-optical switch using two-photon absorption in array of nonlinear ring resonators coupled to MZI

In this paper a novel structure based on Mach-Zehnder Interferometer (MZI) and an array of nonlinear ring resonators for all-optical switching including very low threshold, fast and all-optically tunable is presented. In this proposal, an array including N ring resonators is coupled to one arm of MZI to introduce the required nonlinear phase shift to switching. Also, two-photon absorption phenomenon is used and will be proposed as another alternative for manipulation of optical switching properties. The proposed idea needs small chip area (∝1/Ntraditional cases) for implementation. We show that the switching threshold intensity can be decreased with increase of N, decrease of the coupling coefficient and increase of the two-photon absorption coefficient. In this structure with traditional optical fibers with the low nonlinear index of refractions and using an array including 15 ring resonators with 6 mm diameter for each rings only 3 mW for the switching threshold power is required. Also, using erbium-doped fiber for implementation of the rings with the high nonlinear index of refractions and five ring resonators including 0.3 mm diameter, the switching threshold power can be reduced to μW level. If the nonzero two-photon absorption coefficient is considered, the switching threshold will be very smaller than the above-mentioned values. We show that with changing the optical amplifier gain the switching threshold can be tuned. So, the proposal can be used as a functional block for the integrated optical switch with very small and tunable threshold.     

Dielectric Structure with Periodic Strips for Increasing Radiation Power of Photoconductive Antennas: Theoretical Analysis

Low terahertz (THz) radiation power and low efficiency are the well-known drawbacks of photoconductive antennas (PCAs). To increase THz-radiation power of PCAs, a dielectric structure with periodic low-temperature-grown GaAs strips is proposed. Transmitted power of the proposed structure is obtained from a theoretical model, and further confirmed by finite element simulations. Results show that the structure is capable to transmit into the substrate 90 % of the power of transverse magnetic wave with wavelength as wide as from 0.7 to 1.0 μm. Favorability of this property gets amplified when power transmission in a wide range of frequency bandwidth is desired, e.g., for optical pulse with short duration time incident to PCA, which generates carriers in the semiconductor that create THz emission. Furthermore, the proposed dielectric structure with periodic strips, the whole structure placed in between electrodes of PCA is considered, and analyzed by the existing photoconductive antenna equivalent circuit model, to see how power radiation changes. Interestingly, THz-radiation power enhancements of 70 and 20 % are evinced for, respectively, 20 and 150 mW incident optical powers as instances, as compared to PCA without strips in the gap area.     

An automatic approach for artifacts detection and shadow enhancement in intravascular ultrasound images

Intravascular ultrasound (IVUS) is clinically available for visualizing coronary arteries. However, it suffers from acoustic shadow areas and ring-down artifacts as two of the common issues in IVUS images. This paper introduces an approach which can overcome these limitations. As shadow areas were displayed behind hard plaques in the IVUS grayscale images, calcified plaques were first segmented by using Otsu threshold. Then, active contour, histogram matching, and local histogram matching are implemented. In addition, a new modified circle Hough transform is introduced to remove the ring-down artifacts from IVUS images. In order to evaluate the efficacy of this new method in detection of shadow and ring-down regions, 300 IVUS images are considered. Sensitivity of 89% and specificity of 92% are achieved from a comparison in revelation of calcium along with shadow in the proposed method and virtual histology images. Also, area differences of \(5.83 \pm 3.3\) and \(5.65 \pm 2.83\) are obtained, respectively, for ring-down and shadow domain when compared to measures performed manually by a clinical expert.     

Revamping SiO2 Spheres by Core–Shell Porosity Endowment to Construct a Mazelike Nanoreactor for Enhanced Catalysis in CO2 Hydrogenation to Methanol

Beyond the catalytic activity of nanocatalysts, the support with architectural design and explicit boundary could also promote the overall performance through improving the diffusion process, highlighting additional support for the morphology-dependent activity. To delineate this, herein, a novel mazelike-reactor framework, namely multi-voids mesoporous silica sphere (MVmSiO₂), is carved through a top-down approach by endowing core-shell porosity premade Stöber SiO₂ spheres. The precisely-engineered MVmSiO₂ with peripheral one-dimensional pores in the shell and interconnecting compartmented voids in the core region is simulated to prove combined hierarchical and structural superiority over its analogous counterparts. Supported with CuZn-based alloys, mazelike MVmSiO₂ nanoreactor experimentally demonstrated its expected workability in model gas-phase CO₂ hydrogenation reaction where enhanced CO₂ activity, good methanol yield, and more importantly, a prolonged stable performance are realized. While tuning the nanoreactor composition besides morphology optimization could further increase the catalytic performance, it is accentuated that the morphological architecture of support further boosts the reaction performance apart from comprehensive compositional optimization. In addition to the found morphological restraints and size-confinement effects imposed by MVmSiO₂, active sites of catalysts are also investigated by exploring the size difference of the confined CuZn alloy nanoparticles in CO₂ hydrogenation employing both in-situ experimental characterizations and density functional theory calculations.