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The authors observed 224 patients with neglected forms of carcinoma of distal portions of the colon, 171 (76.3%) of them being considered to be operable. The character of operative interventions depended on neglect of the tumour process which was determined by its spread to the neighbouring organs and tissues. The endolymphatic antibacterial therapy through the inguinal lymph node allowed the perifocal inflammation to be controlled which made the ablation of the tumour and the involved lymph nodes easier. The veritable ingrowth of the tumour into the neighbouring organs and tissues was noted in 15.4% of the patients. Radical operations were performed on 128 patients (74.9%), the other patients were submitted to palliative operations. The strategy of surgical treatment must be based upon the detailed diagnosis of the tumour growth and adequate preoperative preparation including endolymphatic infusions of antibacterial medicine. It allows to increase the amount of radical interventions and widen the indications for performing sphincter-saving operations.  相似文献   
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This study examines how some employeescoped with the exceptions that they encountered withtheir on-going use of a co-operative workflowtechnology in an optronics company. By drawing on thecase material, this paper will indicate thatapproaches which view work as being capable of beingplanned and managed through the formal authority ofthe hierarchy are insufficient. Instead, this paperwill suggest that exception handling, work-arounds andimprovisation are more characteristic of humanactivity. Computer supported co-operative work will beconceptualised as being embedded in a dynamicrelationship between the context it is situatedwithin, and the actors that engage in it. Theprinciples underlying ethnography have informed theresearch approach.  相似文献   
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Diary methods allow researchers to study marital and family processes within the context of daily life in a way that is not possible with more traditional methods. The authors review applications of diary designs in marital and family research and detail the types of research questions that can uniquely be asked of dyadic/family diary data. Technological developments for the use of electronic palm-top devices for implementing diary methods are also reviewed. Additionally, the authors discuss specific issues relevant to the analysis of diary data that come from dyads or families. Last, the authors raise unresolved issues and directions for future research in the use of diary methods for studying marital and family processes. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
6.
We present a new method based on femtosecond laser ablation for the fabrication of statically bent diamond crystals. Using this method, curvature radii of 1 m can easily be achieved, and the curvature obtained is very uniform. Since diamond is extremely tolerant to high radiation doses, partly due to its densely packed lattice, such bent crystals are optimal solutions for crystal-based collimation and/or extraction. Furthermore, using interlaced ablation on both sides, the technique opens for the possibility of constructing a crystalline undulator based on the best material known, to approach the enormous beam densities required for lasing operation of such a device.  相似文献   
7.
We report the heterologous expression, structure, and antimicrobial activity of a lasso peptide, ubonodin, encoded in the genome of Burkholderia ubonensis. The topology of ubonodin is unprecedented amongst lasso peptides, with 18 of its 28 amino acids found in the mechanically bonded loop segment. Ubonodin inhibits RNA polymerase in vitro and has potent antimicrobial activity against several pathogenic members of the Burkholderia genus, most notably B. cepacia and B. multivorans, causative agents of lung infections in cystic fibrosis patients.  相似文献   
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A fast-imaging technique for the total elemental hydrogen concentration distribution is described, which is helpful in the study of its chemistry and dynamics in the diamond system. The micro-scanned Heavy-Ion Elastic Recoil Detection Analysis (HI-ERDA) technique can deliver information on hydrogen distributions in three dimensions. In our system, the count rate is enhanced by use of a 2-D position and energy sensitive detector for the hydrogen recoils. Software geometry collimation and recoil energy rebinning ensure that the increased rate is in fact accompanied by an improvement in effective energy resolution. The system has been used to study the mobility and trapping behaviour of a collimated implant of hydrogen into a pre-damaged natural type IIa diamond sample as well as the mobility and trapping behaviour of collimated implants of hydrogen into diamond, which has not been pre-damaged.  相似文献   
9.
Forensic psychology has made important gains in professional recognition and stature in the courts, resulting in increasing demands for mobility of expertise. Current regulations regarding the interjurisdictional temporary forensic practice of psychology, however, are characterized by variability of regulations, ambiguity and inaccessibility, and continuing total barriers. A uniform, well-reasoned policy is needed. A conceptual basis for such a policy is provided by a discussion of licensing rationales and the application of these to forensic practice. Uniformity, public and professional protection, and practicability are identified as fundamental regulatory criteria. A Model Rule Regarding the Temporary Forensic Practice of Psychology is proposed for adoption by state licensing boards on a nationwide basis. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
10.
Extending the resolution and spatial proximity of lithographic patterning below critical dimensions of 20 nm remains a key challenge with very-large-scale integration, especially if the persistent scaling of silicon electronic devices is sustained. One approach, which relies upon the directed self-assembly of block copolymers by chemical-epitaxy, is capable of achieving high density 1?:?1 patterning with critical dimensions approaching 5 nm. Herein, we outline an integration-favourable strategy for fabricating high areal density arrays of aligned silicon nanowires by directed self-assembly of a PS-b-PMMA block copolymer nanopatterns with a L(0) (pitch) of 42 nm, on chemically pre-patterned surfaces. Parallel arrays (5 × 10(6) wires per cm) of uni-directional and isolated silicon nanowires on insulator substrates with critical dimension ranging from 15 to 19 nm were fabricated by using precision plasma etch processes; with each stage monitored by electron microscopy. This step-by-step approach provides detailed information on interfacial oxide formation at the device silicon layer, the polystyrene profile during plasma etching, final critical dimension uniformity and line edge roughness variation nanowire during processing. The resulting silicon-nanowire array devices exhibit Schottky-type behaviour and a clear field-effect. The measured values for resistivity and specific contact resistance were ((2.6 ± 1.2) × 10(5)Ωcm) and ((240 ± 80) Ωcm(2)) respectively. These values are typical for intrinsic (un-doped) silicon when contacted by high work function metal albeit counterintuitive as the resistivity of the starting wafer (~10 Ωcm) is 4 orders of magnitude lower. In essence, the nanowires are so small and consist of so few atoms, that statistically, at the original doping level each nanowire contains less than a single dopant atom and consequently exhibits the electrical behaviour of the un-doped host material. Moreover this indicates that the processing successfully avoided unintentional doping. Therefore our approach permits tuning of the device steps to contact the nanowires functionality through careful selection of the initial bulk starting material and/or by means of post processing steps e.g. thermal annealing of metal contacts to produce high performance devices. We envision that such a controllable process, combined with the precision patterning of the aligned block copolymer nanopatterns, could prolong the scaling of nanoelectronics and potentially enable the fabrication of dense, parallel arrays of multi-gate field effect transistors.  相似文献   
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