Design of Trehalose-Based Amide/Sulfonamide C-type Lectin Receptor Signaling Compounds

Mincle agonists have been shown to induce inflammatory cytokine production, such as tumor necrosis factor-alpha (TNF) and promote the development of a Th1/Th17 immune response that might be crucial to development of effective vaccination against pathogens such as Mycobacterium tuberculosis. As an expansion of our previous work, a library of 6,6′-amide and sulfonamide α,α-d -trehalose compounds with various substituents on the aromatic ring was synthesized efficiently in good to excellent yields. These compounds were evaluated for their ability to activate the human C-type lectin receptor Mincle by the induction of cytokines from human peripheral blood mononuclear cells. A preliminary structure–activity relationship (SAR) of these novel trehalose diamides and sulfonamides revealed that aryl amide-linked trehalose compounds demonstrated improved activity and relatively high potency cytokine production compared to the Mincle ligand trehalose dibehenate adjuvant (TDB) and the natural ligand trehalose dimycolate (TDM) inducing dose-dependent and human-Mincle-specific stimulation in a HEK reporter cell line.     

Morphological evolution of edge-hillocks on single-crystal films having anisotropic drift-diffusion under the capillary and electromigration forces

The morphological evolution of hillocks at the unpassivated sidewalls of single-crystal metallic thin film interconnects is investigated via computer simulations using the free-moving boundary value problem. The effect of drift-diffusion anisotropy on the development of surface topographical scenarios is fully explored under the action of electromigration and capillary forces, utilizing numerous combinations of the surface texture, the drift-diffusion anisotropy and the direction of the applied electric field. The simulation studies yield analytical relationships for the velocity of the surface solitary waves and the drift velocity of electromigration-induced internal voids as a function of the applied current densities, which contain intrinsic and structural properties of the single-crystal thin films. The threshold value of the applied current density, above which electromigration-induced internal voids can be formed and may cause the catastrophic failure of interconnects by breaching, also appears explicitly in this relationship.     

The effect of fibre orientation of the dry sliding wear of borsic-reinforced 2014 aluminium alloy

The effect of fibre orientation on the dry sliding wear of continuous B(SiC) fibre reinforced aluminium alloy composites was investigated using a pin-on-disc wear testing machine. The metal-matrix composites (MMC) samples were tested in the normal (N), parallel (P) and antiparallel (AP) orientations sliding against a steel counter disc at a fixed speed of 1 m s^–1 under loads of from 12 to 60 N.The results showed that for the matrix alloy and MMCs, the average wear increased linearly with load. Wear of the MMCs was insensitive to fibre content but for composites with fibre contents at or above the minimum of 16 vol% used for this work, the wear rate was about 18% of that of the unreinforced matrix. Fibre orientation had a minor effect on wear rate; the N orientation gave the lowest wear rate with the AP orientation slightly higher and the P orientation significantly higher.The average coefficients of friction of the MMCs in N and AP orientations decreased linearly with increased wear rate and non-linearly with increased load, but the P orientation was insensitive to either variable.It was concluded from these results and a metallographic examination that the mechanism of wear of MMCs was essentially oxidative wear of the matrix. The hard fibres modified this to slightly different degrees depending on their orientation relative to the wear surface and sliding direction.     

Constructing Pseudo-Random Permutations with a Prescribed Structure

We show how to construct pseudo-random permutations that satisfy a certain cycle restriction, for example that the permutation be cyclic (consisting of one cycle containing all the elements) or an involution (a self-inverse permutation) with no fixed points. The construction can be based on any (unrestricted) pseudo-random permutation. The resulting permutations are defined succinctly and their evaluation at a given point is efficient. Furthermore, they enjoy a fast forward property, i.e. it is possible to iterate them at a very small cost. Received 10 August 2000 and revised 30 September 2000 Online publication 9 April 2001     

Thermodynamic analysis of solar photovoltaic cell systems

The thermodynamic characteristics of solar photovoltaic (PV) cells are investigated from a perspective based on exergy. A new efficiency is developed that is useful in studying PV performance and possible improvements. Exergy analysis is applied to a PV system and its components, and exergy flows, losses and efficiencies are evaluated. Energy efficiency is seen to vary between 7% and 12% during the day. In contrast, exergy efficiencies, which incorporate the second law of thermodynamics and account for solar irradiation exergy values, are lower for electricity generation using the considered PV system, ranging from 2% to 8%. Values of “fill factors” are determined for the system and observed to be similar to values of exergy efficiency.     

Oxidation behavior of single-crystal Al2O3-fiber-reinforced Ni3Al-based composites

A series of single-crystal Al₂O₃-fiber-reinforced Ni3Al-based intermetallic matrix composites were fabricated by pressure casting. The matrices employed were binary Ni₃Al, Ni₃Al-0.5 at. pct Cr, and Ni₃Al-0.34 at. pct Zr. The development of microstructure upon oxidation in air at either 1100 °C or 1200 °C was investigated by optical, scanning, and transmission electron microscopy. In air-oxidized binary Ni₃Al, some of the fibers were fully or partially covered with a layer of oxide. A weak fiber/matrix bond in this system, which led to fiber debonding during composite processing, is believed to be responsible for the ingress of O into the composite and oxidation of the matrix in the debonded regions at the fiber/matrix interface. Addition of Cr to Ni₃Al resulted in an almost threefold increase in fiber/matrix bond strength. No oxidation of the interface was observed. A thick layer of oxide was formed around all the fibers when the composite was thermally cycled prior to isothermal annealing. Addition of Zr to Ni₃Al resulted in the formation of a layer of ZrO₂ on the surface of the fibers during composite processing. The ZrO₂ layer provided a fast path for the diffusion of O, which led to the formation of a rootlike oxide structure around the fibers. The rootlike structure consisted of a network of Al₂O₃-covered ZrO₂.     

The IFR/DFR property of the forward recurrence-time distribution

When a failure or replacement process is modeled as a renewal process, the residual life of the unit in use at a given time is generally referred to as the forward recurrence time (RT). Distributional properties of this random variable are critically important in many applications. This paper investigates the extent to which the failure-rate function monotonicity of a life distribution is inherited by the forward RT distribution at time s of its renewal process. For DFR life distributions, the forward RT distribution is also DFR for every s⩾0. However, the corresponding property does not necessarily hold for IFR life distributions. The forward RT distribution is IFR in the limit as s→0 and as s→∞. For IFR Weibull life distributions, we demonstrate numerically that the forward RT distribution is IFR for small s. As s is increased, it alternates between being IFR and non-IFR in an interesting cyclical pattern, and remains IFR beyond a large enough s     

Film morphology and reaction rate for the CVD of tungsten by the WF6—SiH4 reaction

Journal of Electronic Materials - Low pressure chemical vapor deposition (LPCVD) of tungsten (W) by SiH4 reduction of WF6 on Si(100) surfaces was studied in a single-wafer, cold-wall reactor over a...     

Collaborative detection and mitigation of DDoS in software-defined networks

The Journal of Supercomputing - This research presents the detection and mitigation of distributed denial of service (DDoS) in software defined networks (SDN). The proposed method consists of three...