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排序方式: 共有124条查询结果,搜索用时 15 毫秒
1.
OBJECTIVE: Our purpose was to study the heterogeneity of drug response in fresh human ovarian tumors to chemotherapeutic agents in an in vitro chemosensitivity assay. STUDY DESIGN: This assay evaluates total tumor cell kill by measuring the intracellular adenosine triphosphate levels of untreated controls and drug-exposed cells at various doses after culture for 6 days. The surviving fraction is calculated by dividing the treated values with the control values. One hundred tumors were tested against four single drugs (cisplatin, the active metabolite of cytoxan, 4-hydroxyperoxy-cyclophosphamide, Taxol, and carboplatin) and two drug combinations (cisplatin plus 4-hydroxyperoxy-cyclophosphamide; cisplatin plus Taxol). RESULTS: There is great variation in the degree of cell death for single drugs and drug combinations among the 100 tumors tested. CONCLUSION: More effective clinical response to chemotherapy may be achieved in patients with ovarian cancer by selecting the most active drugs for chemotherapy, on the basis of in vitro chemosensitivity test results for individual patients. 相似文献
2.
The software and hardware techniques to exploit the potential of multi-core processors are falling behind, even though the number of cores and cache levels per chip is increasing rapidly. There is no explicit communications support available, and hence inter-core communications depend on cache coherence protocols, resulting in demand-based cache line transfers with their inherent latency and overhead. In this paper, we present Software Controlled Eviction (SCE) to improve the performance of multithreaded applications running on multi-core processors by moving shared data to shared cache levels before it is demanded from remote private caches. Simulation results show that SCE offers significant performance improvement (8-28%) and reduces L3 cache misses by 88-98%. 相似文献
3.
Tankut Atan Olgu Pelin Hüseyinoǧlu 《International Transactions in Operational Research》2017,24(3):465-484
Assignment decisions of referees to football (soccer) games are highly debated in sports media. Referee assignments are typically done on a weekly basis as the league progresses. However, this practice ignores important workload constraints on referees. Moreover, referees' skill levels should also be considered in determining their assignments. In this article, we first give a mixed integer linear program formulation for the problem of simultaneously generating a game schedule and assigning main referees to games by incorporating specific rules in the Turkish league. We also approach this problem using a genetic algorithm (GA) because of the computational difficulties in solving the problem. In the GA solution pool, we suggest using templates for referee assignments that follow several referee‐related workload constraints. We explain how these templates can be obtained by solving a mixed integer linear model prior to running the GA. The usage of these templates for referee assignments is conceptually similar to using a basic match schedule for game scheduling such as the one used in the Turkish Football League. We use the Turkish Football League fixtures for 2010–2013 as a case study. Experiments with the GA using real‐world data show a rather modest performance in terms of computation time and objective function value. Our numerical results indicate that the problem is extremely hard to solve. 相似文献
4.
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Sema Sevinç Şengör Petros Gikas James G Moberly Brent M Peyton Timothy R Ginn 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2012,87(3):374-380
BACKGROUND: Microbial behavior in batch reactors may be different from that in continuous flow reactors, which is expected to affect microbial response to heavy metal exposure. Four parallel continuous flow reactors and batch growth tests were used to investigate the single and joint toxicity of Zn and Cu to Artrobacter sp. JM018. RESULTS: The results indicated that Cu is more toxic than Zn under all conditions. In the batch reactors, all Zn concentrations showed a stimulatory effect on microbial growth. However in the continuous system, 125 µmol L?1 Zn exposure produced inhibition. In the case of mixed Zn and Cu exposures in the batch system, the presence of Zn reduced the severity of Cu inhibition, with a net impact of reduced growth in all cases, whereas in the continuous system microbial growth and substrate utilization rates sharply decreased and ceased. CONCLUSION: The results clearly showed that growth in batch reactors underestimated significantly the heavy metal inhibition, compared with the continuous system. Therefore, the results of batch reactor tests should not be used directly when heavy metal inhibition is to be interpreted for continuous flow systems. Copyright © 2011 Society of Chemical Industry 相似文献
6.
We study the ground-state properties of a Bose-Einstein condensate (BEC) with the short-range repulsion and gravitylike 1/r interatomic attraction in two-dimensions (2D). Using the variational approach, we obtain the ground-state energy and show
that the condensate is stable for all interaction strenghts in 2D. We also determine the collective excitations at zero temperature
using the time-dependent variational method. We analyze the properties of the Thomas-Fermi-gravity (TF-G) and gravity (G)
regimes.
相似文献
7.
Gökçe Çiçek İnce Mustafa Yildirim Kutay Özaydin Pelin Tohumcu Özener 《Bulletin of Engineering Geology and the Environment》2008,67(1):41-51
In this study, the geological and geotechnical conditions of old Istanbul (Fatih and Eminönü provinces) were investigated in detail and a seismic microzonation study was undertaken for this historical peninsula, which is the site of many ancient structures. Dynamic site response, liquefaction potential and slope stability analyses were carried out, based on field and laboratory tests and earthquake time histories computed with respect to probabilities of exceedance of 10 and 40% in 50 years. The output data obtained from the analyses were evaluated by GIS techniques, and ground shaking, liquefaction susceptibility and landslide hazard maps were prepared. 相似文献
8.
Pelin Gundes Bakir Ender Mete Eksioglu Serhat Alkan 《Expert systems with applications》2012,39(18):13289-13294
This study presents application of the CMIF and the Hilbert Transform techniques onto simulated response data obtained using a numerical model of a typical school building from Turkey. White noise is added to the data in order to achieve a noise to signal ratio of 5%. 100 Monte Carlo analysis sequences are carried out and the modal parameters (the frequencies, the mode shapes and the damping ratios) are identified at each Monte Carlo run for both techniques. The results are compared with the identifications obtained from the simulated data using stochastic subspace based system identification technique. The overall results of the study show that the mode shapes are clearly identified the best by using the CMIF technique. The damping ratios are estimated better by using the stochastic subspace based system identification technique whereas the frequencies are best determined by the CMIF. The results also show that both the CMIF and the Hilbert Transform techniques are sensitive to the type of window used as well as the averaging and the decimation process. It is apparent that the CMIF technique is as robust as the frequently used stochastic subspace based system identification technique and can be confidently used for modal parameter estimation of stiff low to mid rise reinforced concrete structures. 相似文献
9.
Pelin Gundes Bakir 《Expert systems with applications》2011,38(12):14390-14397
For the continuous real-time monitoring of structures, the realization of a fully automatic real time system identification without any human intervention is the most crucial step. In this study, a new technique for the automation of the stability diagrams is developed that uses the modal phase collinearity (MPC) in order to quantify the spatial consistency of the identification results. In the new technique, the stabilization diagram is modeled as a histogram composed of overlapping bins. New strategies for the multiple occurrence of poles in the neighboring bins and double poles within a bin are developed. A new cluster validity index is proposed which can solve the problem caused by the scale of measurements and which can be directly calculated from non-normalized data. The threshold limits are defined for the proposed index. The results of the study show that the automation of the pole selection process from the stabilization diagrams is successfully realized. It is also shown that for local modes, the MPC value will be substantially smaller as compared to the global modes and can be used as a quick, efficient and powerful measure of global versus local response behavior. 相似文献
10.