Polyunsaturated fatty acids in tissues of rats fed trielaidin and high or low levels of linolenic acid

Male and female weanling rats that were born to dams fed a diet low in linolenic acid received diets of 15% lipids by weight containing 45% elaidic acid (as trielaidin) and 8.5% or 0.1% linolenic acid for 10 weeks. Four other groups, in which palmitic or oleic acid replaced elaidic acid in the diet, served as controls. The fatty acid profiles of several lipid classes were determined in adipose tissue, adrenals, testes, heart and brain. Elaidic acid was incorporated into tissue lipids in varying degrees, depending on the organ and on the lipid class. Feeding elaidic acid induced no changes in the polyunsaturated fatty acid (PUFA) profiles of testes lipids but resulted in definite modifications of the PUFA patterns of heart phosphatidylcholine (PC) and phosphatidylethanolamine (PE). In linolenic acid-deprived rats, arachidonic acid was decreased in PC and linoleic acid was increased in both PC and PE; 22∶5n−6 was strongly depressed in both PC and PE. In linolenic acid-fed rats, 22∶6n−3 was decreased in PC and PE. These changes, on the whole, were more evident in females, and some also were observed in adrenal cholesteryl esters but only slightly in brain phospholipids. the apparent inhibition of the biosynthesis of PUFA induced by dietary elaidic acid appeared to be complex and of greater intensity in the n−6 fatty acid series than in their n−3 homologues.     

Can distributed generation offer substantial benefits in a Northeastern American context? A case study of small-scale renewable technologies using a life cycle methodology

Renewable distributed electricity generation can play a significant role in meeting today's energy policy goals, such as reducing greenhouse gas emissions, improving energy security, while adding supply to meet increasing energy demand. However, the exact potential benefits are still a matter of debate. The objective of this study is to evaluate the life cycle implications (environmental, economic and energy) of distributed generation (DG) technologies. A complementary objective is to compare the life cycle implications of DG technologies with the centralized electricity production representing the Northeastern American context. Environmental and energy implications are modeled according to the recommendations in the ISO 14040 standard and this, using different indicators: Human Health; Ecosystem Quality; Climate Change; Resources and Non-Renewable Energy Payback Ratio. Distinctly, economic implications are modeled using conventional life cycle costing. DG technologies include two types of grid-connected photovoltaic panels (3 kWp mono-crystalline and poly-crystalline) and three types of micro-wind turbines (1, 10 and 30 kW) modeled for average, below average and above average climatic conditions in the province of Quebec (Canada). A sensitivity analysis was also performed using different scenarios of centralized energy systems based on average and marginal (short- and long-term) technology approaches. Results show the following. First, climatic conditions (i.e., geographic location) have a significant effect on the results for the environmental, economic and energy indicators. More specifically, it was shown that the 30 kW micro-wind turbine is the best technology for above average conditions, while 3 kWp poly-crystalline photovoltaic panels are preferable for below average conditions. Second, the assessed DG technologies do not show benefits in comparison to the centralized Quebec grid mix (average technology approach). On the other hand, the 30 kW micro-wind turbine shows a potential benefit as long as the Northeastern American electricity market is considered (i.e., oil and coal centralized technologies are affected for the short- and long-term marginal scenarios, respectively). Photovoltaic panels could also become more competitive if the acquisition cost decreased. In conclusion, DG utilization will represent an improvement over centralized electricity production in a Northeastern American context, with respect to the environmental, energy and economic indicators assessed, and under the appropriate conditions discussed (i.e., geographical locations and affected centralized electricity production scenarios).     

Electricity sector integration in West Africa

Regional and global integration initiatives push for more electricity sector integration everywhere in the world, including West Africa. The creation of the West African Power Pool (WAPP) in 2000 and important investments under this new structure in 2006 are concrete actions that will result in a more integrated West African electricity sector. But will this integrated sector be more functional than the previous ones? Will the identified electricity sector problems be solved with the new power pool? This paper analyzes how power sector integration is presented by international institutions (the UN Economic Commission for Africa, World Energy Council and World Bank) and identifies three problematic issues with the current integration approach: lack of African ownership, unclear and conflicting reform objectives and uncertainty of integration outcomes.     

Predictive factors of chronic post-traumatic stress disorder 6 months after a road traffic accident

Background

This study sets out to identify risk factors for post-traumatic stress disorder (PTSD) after a road traffic accident with a view to improving prevention.

Methods

The study used a prospective cohort of road traffic accident casualties. All subjects over 15 years of age were recruited in the course of an interview conducted while they were receiving care in a hospital of the Rhône area administrative département. Six months after their accident, they answered a self-administered postal questionnaire that included the Post-traumatic Check-List Scale (PCLS) in order to evaluate PTSD. Multivariate logistic regression analysis was conducted to compare those subjects with a PCLS score of 44 or over with those with a lower score, in order to identify factors that might be associated with PTSD.

Results

592 subjects (out of 1168) returned the 6-month questionnaire and 541 completed the PCLS test. One hundred subjects had a PCLS score ≥44, suggesting PTSD, and 441 subjects did not. The factors associated with PTSD were initial injury severity, post-traumatic amnesia, the feeling of not being responsible for their accident and persistent pain 6 months after it. A lower odds-ratio was associated with users of two-wheel than four-wheel motor vehicles (OR = 0.4; 0.2–0.9).

Conclusion

Besides predictive factors for PTSD (injury severity, post-traumatic amnesia and the feeling of not being responsible for their accident), our study suggested a reduced risk of PTSD among two-wheel motor vehicle users.     

Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324

La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical manifestations ranging from flu-like disease to severe dengue. The nonstructural glycoprotein 1 (NS1) has been identified as playing a key role in dengue disease severity. The intracellular NS1 exists as a homodimer, whereas a fraction is driven towards the plasma membrane or released as a soluble hexameric protein. Here, we characterized the NS1 glycoproteins from clinical isolates DES-14 and RUN-18 that were collected during the DENV-2 epidemics in Tanzania in 2014 and La Reunion island in 2018, respectively. In relation to hepatotropism of the DENV, expression of recombinant DES-14 NS1 and RUN-18 NS1 glycoproteins was compared in human hepatoma Huh7 cells. We observed that RUN-18 NS1 was poorly stable in Huh7 cells compared to DES-14 NS1. The instability of RUN-18 NS1 leading to a low level of NS1 secretion mostly relates to lysine residues on positions 272 and 324. Our data raise the issue of the consequences of a defect in NS1 stability in human hepatocytes in relation to the major role of NS1 in the pathogenesis of the DENV-2 infection.     

Intelligent maximum power tracking control of a PMSG wind energy conversion system

A comparative control study for a maximum power tracking strategy of variable speed wind turbine is provided. The system consists of a direct drive permanent magnet synchronous generator (PMSG) and an uncontrolled rectifier followed by a DC/DC switch‐mode step down converter connected to a DC load. The buck converter is used to catch the maximum power from the wind by generating an efficient duty cycle. Distinct Maximum Power Point Tracking (MPPT) algorithms are analyzed and compared: a classical Proportional‐Integral controller (PI) and two based Fuzzy Logic Controllers (FLC), including a conventional Fuzzy‐PI and an Adaptive FLC‐PI. The main aim of the presented study is to develop an advanced control scheme for wind generators to ensure a high level operating of the system and a maximum power extraction from the wind. This is achieved by analyzing the behavior of the system under fluctuating wind conditions employing Matlab Simpower Systems tool. Simulation results confirm that the Adaptive FLC‐PI controller algorithm has better performances in terms of dynamic response and efficiency especially in comparison with the ones of a PI controller under variable wind speed.     

Assessing the economic value of renewable distributed generation in the Northeastern American market

Incentive programs and tax rebates are commonly offered to offset the high initial costs of small-scale renewable energy systems (RES) and foster their implementation. However, the economic costs of RES grid integration must be fully known in order to determine whether such subsidies are justified. The objective of this paper is to assess the economic value of RES, including their environmental benefits, using hourly generation information in conjunction with hourly wholesale price data. Reaching the paper′s objective will provide a better estimate of the bias that could result from neglecting 1) the time pattern of the hourly wholesale price, 2) the impacts of carbon taxes on the hourly wholesale price and 3) the value of the marginal hourly GHG emissions. Selected RES include two types of grid-connected photovoltaic panels (3 kWp mono- and poly-crystalline) and three types of micro-wind turbines (1, 10 and 30 kW) modeled for different climatic conditions in the province of Quebec (Canada). The cost of electricity is based on the technical performance of these RES using a life cycle costing methodology. The economic value of RES electricity is estimated using the hourly wholesale electricity price in Northeastern American markets in 2006–2008. Results show that distributed generation (DG) has no economic benefits using the selected RES, even with a US$100/tonne of CO₂-equivalent carbon tax. This finding remains the same when the value of the avoided GHG emissions is fully internalized, except for one scenario (micro-wind 30 kW). Our results are key to understanding the extent to which subsidies for distributed RES can be economically sustainable when the latter are integrated into regional networks driven by centralized electricity production.     

Phonons in slow motion: dispersion relations in ultrathin Si membranes

We report the changes in dispersion relations of hypersonic acoustic phonons in free-standing silicon membranes as thin as ～8 nm. We observe a reduction of the phase and group velocities of the fundamental flexural mode by more than 1 order of magnitude compared to bulk values. The modification of the dispersion relation in nanostructures has important consequences for noise control in nano- and microelectromechanical systems (MEMS/NEMS) as well as opto-mechanical devices.     

Microstructure and texture of copper/niobium composites processed by ECAE

The structure refinement is a challenge for conductors used for the winding of resistive coils producing non-destructive pulsed magnetic fields over 80T. These nanocomposite conductors composed of a conducting multiscale Cu matrix embedding Nb reinforcing nanofilaments are usually manufactured by using a Severe Plastic Deformation (SPD) process based on hot extrusion, accumulative cold drawing and bundling (ADB) steps [Thilly et al. Philos Mag A 82:925, 2002]. Equal-channel angular extrusion (ECAE) is investigated here as an alternative route since it may provide faster refinement to obtain the ultrafine structure needed for optimized electrical and mechanical properties of the conductors. Therefore, copper-niobium specimens obtained by hot extrusion were processed by ECAE at room temperature. The specific die of the ECAE tool used here is constituted by a round channel with three angles corresponding to a total equivalent strain of about 2.5. Deformed samples were examined by optical microscopy and characterized by hardness profiles and x-ray diffraction (texture pole figures). After one ECAE-pass, the shape of the samples is modified but no trace of damage appeared at the Cu-Nb interfaces. An increase of the hardness values localized in the copper matrix is revealed whereas the hardness of the niobium remains unchanged. Prior to ECAE, the hot extrusion process induced a fibre texture for both copper and niobium. Two fibre texture components were observed for copper: <111> and <200>. A single <110> fibre texture component is evidenced for the niobium. After ECAE a significant variation of the texture is observed in relation with the strong shear induced by this process.     

Electricity trade and GHG emissions: Assessment of Quebec's hydropower in the Northeastern American market (2006–2008)

Worldwide electricity sector reforms open up electricity markets and increase trades. This has environmental consequences as exports and imports either increase or decrease local production and consequently greenhouse gas (GHG) emissions. This paper's objective is to illustrate the importance of electricity trade's impact on GHG emissions by providing an estimate of the net GHG emissions resulting from these trades. To achieve this objective, Quebec hourly electricity exchanges with adjacent jurisdictions were examined over the 2006–2008 period. In order to associate a specific GHG emission quantity to electricity trades, hourly marginal electricity production technologies were identified and validated using the Ontario hourly output per power plant and information released in the Quebec adjacent system operator reports. It is estimated that over three years, imports into Quebec were responsible for 7.7 Mt of GHG, while Quebec hydropower exports avoided 28.3 Mt of GHG emissions. Hence, the net result is 20.6 Mt of avoided emissions over 2006–2008, or about 7 Mt per year, which corresponds to more than 8% of the Quebec yearly GHG emissions. When GHG emissions from all life cycle stages (resource extraction to end-of-life) are accounted for, the net avoided GHG emissions increase by 35%, to 27.9 Mt.