Organofluorine Hydrazone Derivatives as Multifunctional Anti-Alzheimer's Agents with CK2 Inhibitory and Antioxidant Features

A set of novel hydrazone derivatives were synthesized and analyzed for their biological activities. The compounds were tested for their inhibitory effect on the phosphorylating activity of the protein kinase CK2, and their antioxidant activity was also determined in three commonly used assays. The hydrazones were evaluated for their radical scavenging against the DPPH, ABTS and peroxyl radicals. Several compounds have been identified as good antioxidants as well as potent protein kinase CK2 inhibitors. Most hydrazones containing a 4-N(CH₃)₂ residue or perfluorinated phenyl rings showed high activity in the radical-scavenging assays and possess nanomolar IC₅₀ values in the kinase assays.     

Spray dryer processed graphene oxide/reduced graphene oxide for high-performance supercapacitor

This study deals with the utility of mini spray dryer process to improve the dispersibility, of graphene oxide(GO) and its application for high-performance supercapacitor. Initially, the neutral solution of GO was obtained using the modified Hummer's method. After this, the prepared GO solution was processed by mini spray dryer to obtain a more purified, lighter, and dispersed form of GO which is named as spray dryer processed GO (SPGO). The SPGO thus obtained showed excellent dispersibility behavior with various solvents, which is not found in case of conventional oven drying. Furthermore, utility of SPGO and its reduced form (r-SPGO) for supercapacitor applications have been investigated. Results obtained from the cyclic voltammetry(CV) analysis, impedance, and charge-discharge behavior of supercapacitor fabricated using r-SPGO shows enhanced features. Therefore, the simple spray dried GO and its reduced form, that is, r-SPGO can be utilized as a potential candidate for the supercapacitor application. Herein, as synthesized SPGO exhibited the specific capacitance of 12.07 and 37.6 F/g with PVA-H₃PO₄ and 1 mol/L H₃PO₄, respectively, at a scan rate of 5 mV/s. On the other hand, reduced form of SPGO, that is, r-SPGO showed the specific capacitance of 27.16 and 230 F/g with PVA-H₃PO₄ and 1 mol/L H₃PO₄, respectively.     

Pilot Plant Study of Simultaneous Sewage Sludge Digestion and Metal Leaching

This research is related to a preindustrial pilot scale study of the performance of the simultaneous sewage sludge digestion and metal leaching (SSDML) process for decontamination and stabilization of sewage sludge. Ten batch tests were carried out in two 4?m3 bioreactors under various conditions of operation. Results indicated that the addition of 1.0 to 1.5?g?S0/L, which is the equivalent of approximately 30 to 50?kg?S0 per tons dry sludge, is sufficient to obtain conditions of acidity (pH<2.5) and oxido-reduction potential greater than 500 mV necessary for an effective solubilization of toxic metals. The final average of metal solubilization in the output sludge during the SSDML process varied in the following ranges: 25–78% Cd, 9–32% Cr, 48–100% Cu, 77–99% Mn, 15–53% Ni, 12–47% Pb, and 66–100% Zn. The N, P, and K contents were also preserved in the decontaminated sludge. Moreover, the use of low concentrations of elemental sulfur makes it possible to obtain decontaminated sludge with a low total sulfur content (1.4–1.5% S) compatible with agricultural use. The suspended solids removal calculated for the SSDML process was slightly lower, (2.5±0.4)% volatile suspended solids per day, than those reached using standard aerobic digestion. Finally, the SSDML process was found to be effective in removing bad odors and in the destruction (99–100%) of indicator bacteria.     

Corrosion Behavior of 316LN and 316 Stainless Steels During Long-term Exposure to Aerated 0.5 M NaCl Using Electrochemical Noise Technique

In the present work 316LN as well as 316 stainless steel (SS) coupons each of dimensions (0.025 × 0.018 × 0.006 m³) in well-polished condition were used as two nominal electrodes which were immersed in the aerated solution of 0.5 M NaCl. Correlated current and potential electrochemical noise (EN) signals were collected at 1 Hz sampling frequency for 1 h daily over a period of 30 days. The detrended EN data were used to calculate the noise resistance (R _N) as well as the spectral noise resistance at zero frequency (R _SN^o) values and other statistical parameters. To study the nature of pits and distribution of their diameters as well as depths, extensive observations of the pitted and the blank specimens were carried out using Confocal Laser Scanning Microscopy (CLSM). The current and the potential records of the two alloys showed distinct differences in their corrosion behavior. It was observed that within less than 4 h of immersion, 316SS showed signals indicative of unstable pitting and onset of stable pitting was noticed after 48 h of exposure. However, until about 24 h, 316LN showed just the random signals and unstable pitting was observed after 28 h. The signals clearly indicated continuous growth of the stable pits in 316SS as against the repassivation of the unstable pits in 316LN after 7 days exposure. It was observed that R _N values showed a continuous decrease in the case of 316SS, but were quite stable in the case of 316LN over the exposure period. Concurrent to these observations it was observed that 316SS specimen was extensively pitted. The frequency distributions of pit diameters as well pit depths were observed to be highest at 10-20 μm and 5-10 μm, respectively. However, pits with as large as 70-80 μm diameter and as deep as 20-25 μm too were observed. No pits were observed in case of 316LN even after 30 days of exposure, an observation that corroborates well with the stable R _N values. Thus, in the present investigation, the long-term tests using EN technique coupled with CLSM studies conclusively prove that many unstable pits initiated in 316SS turn into stable ones resulting in insidious localized corrosion attack whereas the unstable pits initiated in 316LN get passivated in the simulated coastal environment.     

Identification of critical erosion prone areas in the small agricultural watershed using USLE,GIS and remote sensing

In the present study, Karso watershed of Hazaribagh, Jharkhand State, India was divided into 200 × 200 grid cells and average annual sediment yields were estimated for each grid cell of the watershed to identify the critical erosion prone areas of watershed for prioritization purpose. Average annual sediment yield data on grid basis was estimated using Universal Soil Loss Equation (USLE). In general, a major limitation in the use of hydrological models has been their inability to handle the large amounts of input data that describe the heterogeneity of the natural system. Remote sensing (RS) technology provides the vital spatial and temporal information on some of these parameters. A recent and emerging technology represented by Geographic Information System (GIS) was used as the tool to generate, manipulate and spatially organize disparate data for sediment yield modeling. Thus, the Arc Info 7.2 GIS software and RS (ERDAS IMAGINE 8.4 image processing software) provided spatial input data to the erosion model, while the USLE was used to predict the spatial distribution of the sediment yield on grid basis. The deviation of estimated sediment yield from the observed values in the range of 1.37 to 13.85 percent indicates accurate estimation of sediment yield from the watershed.     

Correlation analysis of geothermal data in North America

Correlation studies of the geothermal parameters have been carried out for Michigan Basin and the results are interpreted with the help of observed relations between heat flow, geological age and crustal thickness for North America. Heat flow and geothermal gradient are found to decrease with thermal conductivity, while they are positively correlated with each other, supporting the earlier findings of Negi et al. (1974). It is noted that, to some extent, these associations can be explained with the help of variations in crustal thickness.     

Leaching of zinc sulfide concentrate from the ganesh-himal deposit of nepal

The leaching of zinc concentrate obtained from the zinc ore located in the Ganesh-Himal region of Nepal has been carried out in the presence of ammonium persulfate (APS) as an oxidant. Leaching variables such as time, temperature, acid, and oxidant concentration, E _h , and particle size of sphalerite concentrate were studied to optimize the condition and to understand the mechanism of the reaction. The zinc extraction increased up to a temperature of 333 K and a further rise in the temperature to 343 K resulted in lowering of metal extraction. A decrease in particle size and increase in oxidant concentration enhanced the dissolution rate of zinc. The leaching data best fitted to the mixed controlled kinetic model. An activation energy of 43 kJ/mol was obtained for the dissolution of zinc in the temperature range 303 to 333 K with APS. The leaching mechanism was further established by characterizing the original concentrate and the leach residue by X-ray diffraction (XRD) phase identification and scanning electron microscopy (SEM) studies.     

Life quality index for the estimation of societal willingness-to-pay for safety

The engineering and management of human safety is an important societal objective that includes extensive efforts by governments, both legislative and administrative, to enhance the health and safety of the public. Although the achievement of safety goals depend primarily on individuals and organizations responsible for safety, much support is drawn from expertise in diverse scientific and engineering disciplines. The activities range from structural safety (dams, tunnels, bridges to tall buildings) to safe operation of hazardous industrial installations (energy generation facilities, LNG terminals, petrochemical plants) to transportation systems (airline, rail, car safety) to technologies designed to minimize adverse impacts on the environment. All these activities are crucially concerned with risk: with the likelihood and the probable effects of various measures on life and health. We have developed a unified rationale and a clear basis for effective strategic management of risk across diverse sectors. Safety is an important objective in society but it is not the only one. The allocation of society's resources devoted to safety must be continually appraised in light of competing needs, because there is a limit on the resources that can be expended to extend life. The paper presents the Life Quality Index (LQI) as a tool for the assessment of risk reduction initiatives that would support the public interest and enhance safety and quality of life. The paper provides an intuitive reformulation of the LQI as equivalent to a valid utility function that is consistent with the principles of rational decision analysis. The LQI is further refined to consider the issues of discounting of life years, competing background risks, and population age and mortality distribution. The LQI is applied to quantify the societal willingness-to-pay, which is an acceptable level of public expenditure in exchange for a reduction in the risk of death that results in improved life-quality.     

Ultrasonic nondestructive evaluation of fibre-reinforced composite materials — a review

A framework is presented for examining the effectiveness of limiting and modelling arguments used in the analysis of fluid flows. It consists of examining the consequences of the arguments on the flow problem as a whole and breaking down the limiting/modelling process into a sequence of steps and associated sequence of flow problems, termed here as ‘lidels’. The notion of validity of lidels is given. Several examples are given to explain the present approach. Invited general lecture at 3rd ACFM, Tokyo, September 1986