Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia

Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quantitative proteomics approach, the changes in the proteome of KRAS-mutated non-small cell lung cancer (NSCLC) A549 cells in response to trichostatin-A (TSA) and nicotinamide (NAM) under normoxia and hypoxia. Part of this response was further validated by molecular and biochemical analyses and correlated with the proliferation rates, apoptotic cell death, and activation of ROS scavenging mechanisms in opposition to the ROS production. Despite the differences among the KDAC inhibitors, up-regulation of glycolysis, TCA cycle, oxidative phosphorylation and fatty acid synthesis emerged as a common metabolic response underlying KDACi. We also observed that some of the KDACi effects at metabolic levels are enhanced under hypoxia. Furthermore, we used a drug repositioning machine learning approach to list candidate metabolic therapeutic agents for KRAS mutated NSCLC. Together, these results allow us to better understand the metabolic regulations underlying KDACi in NSCLC, taking into account the microenvironment of tumors related to hypoxia, and bring new insights for the future rational design of new therapies.     

测井声波波形与声源的特性有关

根据推导出的圆管状压电换能器在各种激励电压信号作用下的声源函数和谱函数以及声波测井正演问题研究出的石油井孔中任意一点上的声波公式,用计算机技术模拟出了相应的测井记录声波全波列,并将它们输入到声波全波列测井处理程序中进行处理。正演模拟结果和处理结果表明,测井记录的声波全波列不但与所测地层的性质有关,而且与声源的特性有关,声源特性对测井记录的声波全波列的质量有一定的影响。     

Slip and Twinning in Polycrystalline Alumina (α-Al2O3) Deformed under Hydrostatic Pressure between 600° and 1000°C

The microstructure of polycrystalline alumina deformed under hydrostatic pressure and at low temperature is investigated by transmission electron microscopy. Deformation occurs mainly by prism plane slip and rhombohedral twinning. Introduction of hydrogen leads to a significant decrease in the yield stress. In large grain size alumina deformed with hydrogen, accommodation of twinning involves dislocation reactions in the twin boundary and in the grains rather than by cracking. Prism plane dislocations decompose into basal dislocations by cross slip probably due to a decrease of Peierls stress for basal slip in the presence of hydrogen.     

圆管状声波换能器瞬态过程的分析

结合石油测井的实际情况,首次从理论上对常规声波测井仪中采用的圆管状压电陶瓷声波换能器在阶跃电压、冲激电压和正弦间断电压等激励信号的作用下的瞬态过程进行了分析,推导出了在上述几种情况下圆管状压电陶瓷换能器的声源函数和谱函数,并叙述了推导结果在声皮测井中的应用。     

Multiresolution analysis in extraction of reference lines fromdocuments with gray level background

Based on wavelets, a theoretical method has been developed to process multi-gray level documents. In this method, two-dimensional multiresolution analysis, a wavelet decomposition algorithm, and compactly supported orthonormal wavelets are used to transform a document image into sub-images. According to these sub-images, the reference lines of a multi-gray level document can be extracted, and knowledge about the geometric structure of the document can be acquired. Particularly, this approach is more efficient to process form documents with gray level background. Experiments indicate that this new method can be applied to process documents with promising results     

L'IPAH, version canadienne-fran?aise de l'échelle de Levenson mesurant le lieu de contr?le tridimensionnel.

Assessed the reliability and validity of the French-Canadian version of H. Levenson's (1973) internality, powerful others, and chance locus of control scales. Data from 2 studies of 294 middle-class adults show that the French-Canadian version of the scales was comparable to that of the original version. The importance of utilizing the appropriate statistical models of analysis to benefit from the multidimensional model of locus of control is emphasized. (English abstract) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

évaluation du livre intitulé manuel de gérontologie sociale 2.

Reviews the book, Manuel de gérontologie sociiale 2 by Jean Carette (1992). The Handbook of Social Gerontology 2 constitutes a practical complement of volume 1 which related to the social aspects of ageing and the retirement. Volume 2 relates mainly to the social intervention whose objective is to support the action and the collective mobilization individuals and associations of retirements. Using a 30-year experiment with groups of retirees, either in preparation of retirement, or in the collective action, the author approaches a new ground in gerontology. He proposes a new approach--social gerontology, (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Telechelic polydimethylsiloxanes with terminal acetylenic groups prepared by phase-transfer catalysis

Telechelic, hydroxyalkyl terminated polydimethylsiloxanes were obtained under mild conditions via hydrosilylation of allyl alcohol or ethylene glycol monoallyl ether by oligomeric αω-hydride terminated polydimethylsiloxanes, with the use of a platinum catalyst. They were subsequently modified in a phase transfer catalyzed reaction by propargyl bromide, to give telechelic polysiloxanes terminated by acetylenic groups. The synthetic pathway is described and the characterization of the obtained products is presented.     

汽车侧倾稳定性的动态仿真(一) --数学模型的建立

本文通过对独立悬架和非独立悬架侧倾运动特性的分析并结合采用已有的轮胎力学模型，建立了反映独立悬架和非独立悬架侧倾运动特性的数学模型。在此基础上，根据汽车侧倾时悬挂质量对前后悬架的力和力矩作用来组合前后悬架，我们得到了双轴汽车在稳态转向时侧倾运动的数学模型。通过组合不同的前后悬架，这个数学模型可以反映各种悬架配置的双轴汽车。它主要是针对汽车进行稳态转向时的侧倾情况，考虑了汽车的结构参数、惯性参数以及悬架、轮胎的柔性形变对汽车侧倾运动特性和抗侧翻能力的影响。它可以用来计算一定横向加速度下汽车的侧倾反应和轮胎的载荷变化，也可以用来计算一辆确定的汽车在保持侧倾稳定性的前提下所能达到的最大横向加速度，还可以用来分析各项参数对汽车侧倾稳定性的影响。