Clean Technologies and Environmental Policy - This work investigates the removal of non-aqueous phase liquids (NAPLs) from groundwater resources using nanotechnology. We present results of a series... 相似文献
The existence of small numbers of schizophrenia patients with superior ability in specific cognitive domains is implied by meta-analytic evidence as well as by occasional empirical reports. The authors identified 25 patients with superior (i.e., ≥90th percentile) ability on the Vocabulary subtest of the Wechsler Adult Intelligence Scale 3rd edition (Wechsler, 1997). These cognitively advantaged patients were compared with 22 healthy participants performing at the superior level and with 126 schizophrenia patients and 50 healthy participants scoring below the superior range. Verbally superior schizophrenia patients and verbally superior healthy participants had similar cognitive profiles and life skills performance, but diverged markedly in terms of independent "real-world" functioning. Verbally superior patients significantly outperformed more typical patients in other aspects of cognitive performance, life skills, and support requirements. However, severity of positive and negative symptoms was equivalent in the patient groups. Detailed biobehavioral study of cognitively exceptional patients may offer new insights into mechanisms mediating psychotic disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
Atherosclerosis is a major cause of human cardiovascular disease, which is the leading cause of mortality around the world. Various physiological and pathological processes are involved, including chronic inflammation, dysregulation of lipid metabolism, development of an environment characterized by oxidative stress and improper immune responses. Accordingly, the expansion of novel targets for the treatment of atherosclerosis is necessary. In this study, we focus on the role of foam cells in the development of atherosclerosis. The specific therapeutic goals associated with each stage in the formation of foam cells and the development of atherosclerosis will be considered. Processing and metabolism of cholesterol in the macrophage is one of the main steps in foam cell formation. Cholesterol processing involves lipid uptake, cholesterol esterification and cholesterol efflux, which ultimately leads to cholesterol equilibrium in the macrophage. Recently, many preclinical studies have appeared concerning the role of non-encoding RNAs in the formation of atherosclerotic lesions. Non-encoding RNAs, especially microRNAs, are considered regulators of lipid metabolism by affecting the expression of genes involved in the uptake (e.g., CD36 and LOX1) esterification (ACAT1) and efflux (ABCA1, ABCG1) of cholesterol. They are also able to regulate inflammatory pathways, produce cytokines and mediate foam cell apoptosis. We have reviewed important preclinical evidence of their therapeutic targeting in atherosclerosis, with a special focus on foam cell formation. 相似文献
Multidimensional Systems and Signal Processing - Medical imaging has been an indispensable tool in modern medicine in last decades. Various types of imaging systems provide structural and... 相似文献
Local heat transfer coefficients and pressure drops during boiling of the dielectric liquid fluorinert FC-77 in parallel microchannels were experimentally investigated in recent work by the authors. Detailed visualizations of the corresponding two-phase flow regimes were performed as a function of a wide range of operational and geometric parameters. A new transition criterion was developed for the delineation of a regime where microscale effects become important to the boiling process and a conventional, macroscale treatment becomes inadequate. A comprehensive flow regime map was developed for a wide range of channel dimensions and experimental conditions, and consisted of four distinct regions – bubbly, slug, confined annular, and alternating churn/annular/wispy-annular flow regimes. In the present work, physics-based analyses of local heat transfer in each of the four regimes of the comprehensive map are formulated. Flow regime-based models for prediction of heat transfer coefficient in slug flow and annular/wispy-annular flow are developed and compared to the experimental data. Also, a regime-based prediction of pressure drop in microchannels is presented by computing the pressure drop during each flow regime that occurs along the microchannel length. The results of this study reveal the promise of flow regime-based modeling efforts for predicting heat transfer and pressure drop in microchannel boiling. 相似文献
Heat transfer with liquid–vapor phase change in microchannels can support very high heat fluxes for use in applications such as the thermal management of high-performance electronics. However, the effects of channel cross-sectional dimensions on the two-phase heat transfer coefficient and pressure drop have not been investigated extensively. In the present work, experiments are conducted to investigate the local flow boiling heat transfer of a dielectric fluid, Fluorinert FC-77, in microchannel heat sinks. Experiments are performed for mass fluxes ranging from 250 to 1600 kg/m2 s. Seven different test pieces made from silicon and consisting of parallel microchannels with nominal widths ranging from 100 to 5850 μm, all with a nominal depth of 400 μm, are considered. An array of temperature sensors on the substrate allows for resolution of local temperatures and heat transfer coefficients. The results of this study show that for microchannels of width 400 μm and greater, the heat transfer coefficients corresponding to a fixed wall heat flux as well as the boiling curves are independent of channel size. Also, heat transfer coefficients and boiling curves are independent of mass flux in the nucleate boiling region for a fixed channel size, but are affected by mass flux as convective boiling dominates. A strong dependence of pressure drop on both channel size and mass flux is observed. The experimental results are compared to predictions from a number of existing correlations for both pool boiling and flow boiling heat transfer. 相似文献
Nanopore molecularly imprinted polymers and membranes for selective separation of 2,4-dichlorophennoxyacetic acid were prepared using 2,4-dichlorophennoxyacetic acid as a template molecule, methacrylic acid as a functional monomer and trimethylolpropane trimethacrylate as a cross linker. Recognition properties of molecularly imprinted membranes were evaluated by performing binding experiments with analog phenoxyacetic acid. Flux, permeability, and permselectivity of the membranes as well as their properties were studied. Molecularly imprinted membrane-2 showed the equilibrium binding capacity of 34.57 mg/g and a selectivity factor of 12.96 toward 2,4-dichlorophennoxyacetic acid at 500 mg/l concentration. Permeability experiments indicated that molecularly imprinted membrane can recognize and absorb 2,4-dichlorophennoxyacetic acid from aqueous solutions’ selectively. 相似文献
In this paper, the underwater implementation of the incremental adaptive networks is proposed based on the visible light communication technology. The underwater distance between transmitter and receiver nodes and the salinity and temperature levels of the considered water determines the stochastical properties of the underwater link that is modeled with the Log-normal distribution. The incremental network performance can be expressed with the excess mean square error and mean square deviation values and we used them in this paper for our theoretical analysis. Our findings showed that the distances between the nodes must not be more than 10 m or the incremental network will diverge from its estimation goal. The network performance is analyzed through multiple link distances and the results are presented with several simulations. The simulation results are devised in order to elaborate the effects of the underwater turbulent links on the performances of estimating adaptive network. Also, the impacts of different salinity and temperature levels are analyzed theoretically and the results are compared with the simulation results.