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1.
Warren Webb 《电子设计技术》2006,13(11):58-60,62,65
随着嵌入设备渗透进社会,并承担起更加重要的角色,安全失效会带来潜在的灾难性的后果。嵌入设备以无人干预方式运行在很多领域的数千种关键任务或安全相关系统中,如制造、健康保健、运输、金融和军事等。虽然我们不假思索地依赖于这些嵌入系统,但任何一种嵌入系统都可能成为临时黑客、犯罪团伙、恐怖分子,甚至敌对政府分子的潜在目标。阻止这些攻击的重任就落在了系统设计者的肩上,他不仅要保证通过或保存在嵌入设备中的数据的安全,而且还要保护产品本身的知识产权。 相似文献
2.
S Harino M Motokura N Nishikawa M Fukuda A Sasaoka JE Grunwald 《Canadian Metallurgical Quarterly》1994,117(3):302-307
We studied the ocular findings of two adult patients with the Eisenmenger's syndrome who had atrial septal defects that were diagnosed before the age of 10 years but not operated on and pulmonary hypertension. Both eyes of these patients showed microaneurysms, multiple small blot hemorrhages, or capillary dilation in the temporal peripheral fundus. Multiple microaneurysms and retinal collaterals were confirmed by fluorescein angiography. One of the patients developed bilateral rubeosis iridis with slow progression. These retinal lesions and the rubeosis iridis are probably related to chronic ocular ischemia caused by chronic systemic hypoxia. 相似文献
3.
The short contact time dissolution of vitrinite and inertinite concentrates of an Australian bituminous coal was studied under isothermal conditions with tetralin as solvent. The reactivity of the two maceral types and the yields and nature of the products were determined for a range of reaction temperatures (400, 420 and 440 °C) and reaction times (2–20 min). The dissolution of vitrinite proceeded at a significantly greater rate than for inertinite and was associated with greater selectivity to soluble non-gaseous products. At very short reaction times (2 min), the vitrinite underwent solubilizing reactions to yield products of higher molecular weight and greater oxygen functionality than was the case for inertinite, for which changes in the chemical nature of the products were negligible over the range of conditions studied. At longer reaction times (5 min), the composition of the vitrinite-derived products was similar to that of the inertinite-derived products. 相似文献
4.
Chwen-Jyh Jeng Warren B. Kindzierski Daniel W. Smith 《Canadian Metallurgical Quarterly》2007,133(3):331-339
This paper presents a particle penetration model predicting particle penetration coefficient (Pp) through a narrow crack of arbitrary incline angles (θ). The objective was to simulate Pp for outdoor-to-indoor particle penetration for residential infiltration conditions. This model assumes laminar infiltration flow and considers particle deposition from both gravitational sedimentation and Brownian diffusion. For micron-sized particles, modeling results indicate that gravitational sedimentation is the major deposition mechanism. Pp increases monotonically with ∣θ∣ because effective particle sedimentation velocity (vs?cos?θ) decreases monotonically with ∣θ∣. For submicron-sized particles (0.1?μm), Brownian diffusion is the major particle deposition mechanism. Because Brownian diffusion is a nondirectional deposition mechanism, crack inclination did not affect Pp. This study applied this model to estimate Pp for L-shaped cracks, and validated modeling results with experiments. Experimental results indicated that inertial impaction and crack entrance cutoff effects were not significant particle deposition mechanisms for the test micron-sized particles. Gravitational sedimentation was the major deposition mechanism. An L-shaped crack can be simulated as the combination of horizontal and vertical sections. This model agreed reasonably with experimental results. 相似文献
5.
6.
J Hellman EM Zanzot PM Loiselle SF Amato KM Black Y Ge JT Kurnick HS Warren 《Canadian Metallurgical Quarterly》1997,176(5):1260-1268
The binding of IgG in antiserum to Escherichia coli J5 to the surface of Enterobacteriaceae and to cell wall fragments released from serum-exposed bacteria was studied in a search for potentially protective epitopes other than lipopolysaccharide (LPS). IgG titers to multiple heterologous gram-negative smooth bacteria increased following incubation of the bacteria in serum and decreased following absorption with serum-exposed heterologous bacteria. IgG eluted from absorbing bacteria bound to at least three conserved bacterial outer membrane proteins (OMPs), but not LPS, as assessed by immunoblotting. The same OMPs were present in LPS-containing macromolecular cell wall fragments released by incubation of heterologous gram-negative bacteria in human serum. Part of the protection offered by J5 antiserum could be from binding of IgG to conserved OMPs at the bacterial surface or to OMPs in cell-wall fragments released from dying bacteria. 相似文献
7.
HL Hinds CT Ashley JS Sutcliffe DL Nelson ST Warren DE Housman M Schalling 《Canadian Metallurgical Quarterly》1993,3(1):36-43
Prostaglandin E2 levels in isolated rat islets were increased from 64 +/- 11 pg/30 islets when incubated in medium containing 2 mM glucose to 115 +/- 9 pg/30 islets in medium containing 20 mM glucose. In contrast, glyceraldehyde (10 mM) reduced prostaglandin E2 levels to 29 +/- 6 pg/30 islets. Inhibition of glucose metabolism by mannoheptulose (10 mM) abolished the stimulatory effect of glucose on prostaglandin E2 levels and inhibited glucose-induced insulin release. The cyclooxygenase inhibitor, flurbiprofen (20 microM), did not affect insulin release caused by glucose or glyceraldehyde. In the presence of 1 mg/ml bovine serum albumin, insulin secretion induced by 20 mM glucose (6.9 +/- 1.1% of islet insulin content) was reduced by the lipoxygenase inhibitor BW755 C (20 microM) to 3.1 +/- 0.6%, and by the phospholipase A2 inhibitor, p-bromophenacyl bromide (10 microM), to 2.1 +/- 0.8%. In the absence of bovine serum albumin the inhibitory action of BW755 C and p-bromophenacyl bromide on glucose-induced insulin release was significantly more pronounced. These drugs whether in the presence or absence of bovine serum albumin, did not affect glyceraldehyde-stimulated insulin secretion. Glyceraldehyde (10 mM), potentiated glucose-induced insulin release in the presence of 2-8 mM glucose, but not for 10-20 mM glucose. Although the phospholipase A2 activator, melittin, initiated insulin release in the presence of 2 mM glucose and enhanced 10 mM glyceraldehyde-stimulated insulin secretion it had no effect on 20 mM glucose-induced insulin release. These two stimulatory effects of melittin on insulin release were totally abolished by p-bromophenacyl bromide.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
8.
HS Warren 《Canadian Metallurgical Quarterly》1996,74(5):473-480
Considerable progress has been made in recent years in understanding the biology of NK cells. NK cells are no longer 'null cells', but express an array of functionally important molecules with which they mediate and regulate their cytolytic activity and the cytokines they secrete. Activation and proliferation of NK cells in influenced by cytokines produced by activated monocytes (IL-15, IL-12, IL-10) and activated T cells (IL-2). This paper reviews the phenotype and effector functions of NK cells, their tissue distribution, and evidence that NK cells proliferate in vivo as part of productive or pathologic consequences of immunity. 相似文献
9.
K Jin-no M Tanimizu I Hyodo Y Nishikawa Y Hosokawa H Endo T Doi K Mandai H Ishitsuka 《Canadian Metallurgical Quarterly》1998,82(7):1260-1267
BACKGROUND: Platelet-derived endothelial cell growth factor (PD-ECGF) is an angiogenic factor that is expressed in various cancer tissues. Little is known regarding plasma PD-ECGF levels in patients with chronic liver disease such as chronic hepatitis (CH), cirrhosis, and hepatocellular carcinoma (HCC) with cirrhosis. The expression of PD-ECGF in HCC tissues also remains to be clarified. METHODS: Plasma PD-ECGF levels in patients with chronic liver disease were determined with an enzyme-linked immunoadsorbent assay system using the mouse monoclonal antibodies specific to PD-ECGF. These were cross-sectionally compared among groups of normal persons, CH, cirrhosis, and HCC patients. The HCC patients were classified into two groups based on TNM stage: early and advanced stage disease groups. PD-ECGF expressions in HCC tissues were immunohistologically examined. RESULTS: The plasma PD-ECGF levels from the normal individuals and those with CH, cirrhosis, and HCC specimens were 4.2+/-0.5, 4.3+/-0.6, 4.6+/-1.1, and 6.0 +/-2.5 U/mL, respectively. The plasma PD-ECGF concentration was highest in HCC (P < 0.05). No significant difference was found among the normal subjects, CH, and cirrhosis specimens. Plasma PD-ECGF concentrations were significantly higher in the advanced stage disease HCC group compared with the early stage disease group (6.75+/-2.62 U/mL vs. 4.19+/-0.34 U/mL) (P < 0.05). Immunohistochemical expression of PD-ECGF in HCC cells increased significantly compared with normal liver cells (P < 0.05). CONCLUSIONS: Circulating PD-ECGF plasma level might be a new tumor marker for progression in patients with HCC. Immunohistological findings correspond to elevation of the plasma PD-ECGF in HCC patients. It is possible that increased production of PD-ECGF in HCC cells causes abundant neovascularization. 相似文献
10.
An efficient method is described for sensitivity analysis of nonlinear initial value problems, which may include algebraic equations as well as ordinary differential equations.The linearity of the sensitivity equations is utilized to solve them directly via the local Jacobian of the state equations. The method is implemented with the implicit integrator DASSL and is demonstrated on a stiff industrial reaction model. 相似文献