Squamous cell carcinoma of the prostate: case report and review of literature

Carcinoma of the prostate, that is adenocarcinoma, is one of the most common malignancies in the male with an estimated incidence for 1991 of 122,000 new cases. On the other hand, squamous cell carcinoma of the prostate, with a median incidence of .5%-1% of all prostatic malignancies, has a similar clinical presentation but differs in treatment response and prognosis. We herein present one case of this histological pattern and review the literature pertaining to it.     

Cascade damage evolution: rate theory versus kinetic Monte Carlo simulations

The thermal evolution of defects produced by ion irradiation is studied by kinetic Monte Carlo and Rate Theory approaches. An isochronal annealing is simulated to evidence the different thermally activated mechanisms that govern defect evolution. KMC simulations show that in the case of ion irradiation, additional recovery peaks should be expected, in comparison to electron irradiation conditions. A comparison between kMC and RT results indicates that some of these peaks are due to spatially – correlated recombinations that occur at low temperature. Therefore kMC and RT approaches differ at low temperature. However, at higher temperature results obtained by both models are in near perfect agreement. In addition, we studied the influence of vacancy cluster mobility on the evolution of damage. KMC simulations show that the mobility of V₂, V₃ and V₄ clusters does not significantly affect the evolution of defects and can be neglected in these conditions.     

Red-green colour blindness in the Tormes-Alberche Valley (Avila-Central Spain)

A population from a Central Spanish region (Tormes-Alberche Valley) has been investigated for the presence of red-green colour vision defects. A sample of 998 subjects (469 male and 529 female) was analyzed. To identify colour vision defects, Ishihara test plates were used. The red-green colour blindness percentage obtained was 4.69 +/- 0.976% for males (2.13% protan and 2.56% deutan types) and none of the females tested were found to be colour blind. These results are within the variation range of Mediterranean populations and lower than the usual frequencies among non-Mediterranean European samples.     

Synthesis and cytotoxicity of potential tumor-inhibitory analogues of trimelamol (2,4,6-tris[(hydroxymethyl)methylamino]-1,3,5-triazine) having electron-withdrawing groups in place of methyl

In exploring the structural features which determine the antitumor activity of 2,4,6-tris-[(hydroxymethyl)methylamino]-1,3,5-triazine (trimelamol, 1), we have synthesized analogues in which the methyl groups have been replaced by the electron-withdrawing substituents 2,2,2-trifluoroethyl (5), propargyl (13), and cyanomethyl (15) via the respective tris(alkylamino)triazines 3, 12, and 14. Three mono[(hydroxymethyl)amino]triazines (4, 7, and 10) were also prepared. All the new tris(hydroxymethyl) derivatives showed cytotoxicities toward a variety of experimental rodent and human ovarian tumor cell lines similar to those shown by 1, the cyanomethyl analogue (15) having the most favorable profile. Mono(hydroxymethyl) derivatives (4 and 7) were ca. one-third as toxic. The new tris(hydroxymethyl) analogues were more stable to aqueous hydrolysis than was 1. Half-life (pH 7.5) values were, for 1, 120 min, for 5, 690 min, for 13, 450 min, and for 15, 275 min, but at pH 2.0, 15 (t1/2 350 min) was the most stable. This cyanomethyl analogue was also the most water-soluble, being comparable to 1 whereas 5 and 13 were poorly soluble.     

Hierarchical Self‐Assembly of Peptide‐Coated Carbon Nanotubes

Numerous applications, from molecular electronics to super‐strong composites, have been suggested for carbon nanotubes. Despite this promise, difficulty in assembling raw carbon nanotubes into functional structures is a deterrent for applications. In contrast, biological materials have evolved to self‐assemble, and the lessons of their self‐assembly can be applied to synthetic materials such as carbon nanotubes. Here we show that single‐walled carbon nanotubes, coated with a designed amphiphilic peptide, can be assembled into ordered hierarchical structures. This novel methodology offers a new route for controlling the physical properties of nanotube systems at all length scales from the nano‐ to the macroscale. Moreover, this technique is not limited to assembling carbon nanotubes, and could be modified to serve as a general procedure for controllably assembling other nanostructures into functional materials.     

A stochastic maximum principle for systems with jumps, with applications to finance

We consider a stochastic control problem with linear dynamics with jumps, convex cost criterion, and convex state constraint, in which the control enters the drift, the diffusion, and the jump coefficients. We allow these coefficients to be random, and do not impose any L^p-bounds on the control.

We obtain a stochastic maximum principle for this model that provides both necessary and sufficient conditions of optimality. This is the first version of the stochastic maximum principle that covers the consumption–investment problem in which there are jumps in the price system.     

Shumbler: a 155 Mb/s BiCMOS synchronous multiplexer chip for abroad-band customer premises network

The shumbler (shuffler/scrambler) is a circuit designed and fabricated to form part of a broadband customer premises network. The circuit is implemented in 1.2-μm BiCMOS double-metal technology. The circuit is bidirectional, and can perform the functions of scrambling and shuffling or descrambling and unshuffling by means of control signals to three integrated multiplexers. The shumbler also includes a programmable multiplexer that allows the selection of one out of the 16 output channels of the shuffler through a serial output for local system test purposes. The shumbler circuit interfaces emitter-coupled-logic (ECL) and transistor-transistor-logic (TTL) logic levels using a single power supply of -5 V, dissipating 1.5 W, and encapsulated in a 68-pin LCC package with a flat heat spreader which ensures a thermal resistivity of about 10°C/W     

Communication Law and Policy: The State of Research and Theory

This essay describes the domain of research in communication law and policy. It is based on a content analysis of research published in the journal Communication Law and Policy (1996–2004), papers presented to the Communication Law and Policy Division at annual conferences of the International Communication Association (1997–2004), as well as consideration of other resources. The most frequent areas for research were media regulation, Internet policy, and freedom of expression issues. After reviewing recent literature on the first two topics, we identified and showcased two emergent categories deserving future attention: communication and the law (particularly fair trial-free press issues) and implications of the burgeoning consolidation of media ownership.