The Bi2O3-SrO phase diagram

The phase relations in the Bi₂O₃-SrO system have been examined in air at temperatures above 740 °C. Intermediate phases were found to agree with previous work, but the homogeneity ranges and high-temperature phase relationships were in some cases at variance. A modified phase diagram is proposed.     

Pinhole density measurements of barriers deposited on low-k films

Evaluation of diffusion barrier integrity is an important issue in advanced interconnects. A diffusion barrier separating Cu from low-k must be as thin as possible and must not contain pinholes. We have developed a method for measuring pinhole density in diffusion barriers deposited on low-k materials. The method employs ellipsometric porosimetry for measuring diffusion of toluene in a porous low-k film beneath the barrier in question.     

GPU-OSDDA: a bit-vector GPU-based deadlock detection algorithm for single-unit resource systems

This article presents a GPU-based single-unit deadlock detection methodology and its algorithm, GPU-OSDDA. Our GPU-based design utilizes parallel hardware of GPU to perform computations and thus is able to overcome the major limitation of prior hardware-based approaches by having the capability of handling thousands of processes and resources, whilst achieving real-world run-times. By utilizing a bit-vector technique for storing algorithm matrices and designing novel, efficient algorithmic methods, we not only reduce memory usage dramatically but also achieve two orders of magnitude speedup over CPU equivalents. Additionally, GPU-OSDDA acts as an interactive service to the CPU, because all of the aforementioned computations and matrix management techniques take place on the GPU, requiring minimal interaction with the CPU. GPU-OSDDA is implemented on three GPU cards: Tesla C2050, Tesla K20c, and Titan X. Our design shows overall speedups of 6-595X over CPU equivalents.     

Ensembles of decision trees based on imprecise probabilities and uncertainty measures

In this paper, we present an experimental comparison among different strategies for combining decision trees built by means of imprecise probabilities and uncertainty measures. It has been proven that the combination or fusion of the information obtained from several classifiers can improve the final process of the classification. We use previously developed schemes, known as Bagging and Boosting, along with a new one based on the variation of the root node via the information rank of each feature of the class variable. To this end, we applied two different approaches to deal with missing data and continuous variables. We use a set of tests on the performance of the methods analyzed here, to show that, with the appropriate approach, the Boosting scheme constitutes an excellent way to combine this type of decision tree. It should be noted that it provides good results, even compared with a standard Random Forest classifier, a successful procedure very commonly used in the literature.     

Application of top seeding in the melt processing of Nd<Subscript>123</Subscript> thick films on YSZ substrates: I buffer layer optimization

A new concept of a buffer layer in superconducting thick film technology was tested. The idea is based on increasing the NdBa₂Cu₃O_x melt viscosity at the processing temperature near the substrate by using higher ratios of Nd₄Ba₂Cu₂O_z solid phase in the first screen printed pass which is considered as a buffer layer. Different compositions, thicknesses and thermal schedules were used to optimise the buffer layer. The optimised buffer layer was employed in the fabrication of NdBa₂Cu₃O_y thick films on yttria stabilized zirconia (YSZ) substrates using the top seeding melt growth (TSMG) technique. Using the buffer layer was effective in preventing a large amount of liquid (BaCuO₂-CuO) from severe interaction with the substrate during the prolonged time in the TSMG technique. Consequently, a large superconducting single domain was obtained. Thick films were melt processed in 0.1% O₂ in Ar atmosphere to suppress the Nd_{1 + x}Ba_{2 − x}Cu₃O_y (Nd_123SS) solid solution formation. The produced thick films have high transition temperature (T_C) and improved microstructures.     

Calibration of AFM cantilever spring constants

In this paper we present two simple, reliable and readily applicable methods for calibrating cantilevers and measuring the thickness of thin gold films. The spring constant calibration requires knowledge of the Young's modulus, density of the cantilever and resonant frequency. The thickness of thin gold layers was determined by measuring changes in the resonant frequency and Q-factor of beam shaped AFM cantilevers before and after coating.The techniques for measuring the spring constant and thin film thickness provide accuracy on the order of 10-15%.     

Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification

One of the initial steps of modern drug discovery is the identification of small organic molecules able to inhibit a target macromolecule of therapeutic interest. A small proportion of these hits are further developed into lead compounds, which in turn may ultimately lead to a marketed drug. A commonly used screening protocol used for this task is high-throughput screening (HTS). However, the performance of HTS against antibacterial targets has generally been unsatisfactory, with high costs and low rates of hit identification. Here, we present a novel computational methodology that is able to identify a high proportion of structurally diverse inhibitors by searching unusually large molecular databases in a time-, cost- and resource-efficient manner. This virtual screening methodology was tested prospectively on two versions of an antibacterial target (type II dehydroquinase from Mycobacterium tuberculosis and Streptomyces coelicolor), for which HTS has not provided satisfactory results and consequently practically all known inhibitors are derivatives of the same core scaffold. Overall, our protocols identified 100 new inhibitors, with calculated K_i ranging from 4 to 250 μM (confirmed hit rates are 60% and 62% against each version of the target). Most importantly, over 50 new active molecular scaffolds were discovered that underscore the benefits that a wide application of prospectively validated in silico screening tools is likely to bring to antibacterial hit identification.     

Femtosecond Dynamics of BSCCO-2212

We present measurements of the dynamics of the electronic excitations of BSCCO-2212 measured with 150fs resolution using ultrafast time-resolved spectroscopy. The dynamics is clearly different in the normal, pseudogap and superconducting states, and from that measured in YBa ₂ Cu ₃ O _7– .