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排序方式: 共有242条查询结果,搜索用时 15 毫秒
1.
H Asamoto M Kawahara F Iwami M Kuba K Furuse T Tamura N Saijo M Shimoyama 《Canadian Metallurgical Quarterly》1998,28(12):745-748
BACKGROUND: Etoposide is a highly schedule-dependent drug. We investigated combination chemotherapy of oral etoposide and intravenous cisplatin for small cell lung cancer (SCLC). METHODS: Fifty-seven patients with SCLC with extensive disease (ED) or limited disease (LD) with pleural effusion registered in the 21 institutions of the Japan Clinical Oncology Group were treated with oral etoposide 40 mg/m2/d for 21 days and cisplatin 80 mg/m2 on day 1 of every 28-period day. The entry period was between February 1992 and August 1995. The actual percentages of patients treated with etoposide were 93.6, 89.5, 92.3 and 96.9% in the first, second, third and fourth cycles, respectively. RESULTS: Nine patients (15.8%) achieved a complete response resulting in an overall response rate of 82.5% (95% confidence interval, 70.1-91.3%). Leukopenia and thrombocytopenia of grade 3 or 4 were observed in 36 (49.1%) and 8 (14.0%) patients, respectively. Anemia of grade 3 or 4 occurred in 28 (49.1%) patients. Nausea, vomiting, anorexia and alopecia were common adverse events. One patient died of hemoptysis due to grade 4 thrombocytopenia. The mean survival time was 47.0 weeks. CONCLUSIONS: This dose and schedule of administration of etoposide in combination with cisplatin are considered to be clinically active. However, prolonged gastrointestinal toxicity of oral etoposide was a problem in comparison with the standard etoposide platinum regimen given by intravenous administration. 相似文献
2.
Tsunehiro Aki Kazutaka Hachida Megumi Yoshinaga Yuko Katai Takashi Yamasaki Seiji Kawamoto Toshihide Kakizono Takashi Maoka Seiko Shigeta Osamu Suzuki Kazuhisa Ono 《Journal of the American Oil Chemists' Society》2003,80(8):789-794
Thraustochytrids, marine protists whose dominant genera are Thraustochytrium and Schizochytrium, belong to the kingdom Chromista and are known as an industrial source of DHA. We describe here that thraustochytrid strain
KH105, isolated as a DHA producer, also accumulates significant levels of β-carotene and xanthophylls including canthaxanthin
and astaxanthin. A4-d cultivation using a medium composed of 10% glucose and less than 0.3% of nitrogen sources in a half-concentration
of seawater gave an astaxanthin production up to 6.1 mg/L, and canthaxanthin content reached more than 10 mg/L under conditions
where a higher concentration of nitrogen sources (6%) was employed. It might be advantageous in mass production systems for
these carotenoids to be extracted readily by simply suspending the cells with organic solvents such as acetone and chloroform.
Analyses on the morphological and life history features of the KH105 strain revealed that it belongs to the genus Schizochytrium. This particular species of thraustochytrids is thus considered to be a promising source of xanthophylls as well as DHA for
use in the food industry. 相似文献
3.
Kojima Masami Tasaki Takafumi Suzuki Yukihisa Kamijo Toshio Hada Aki Kik Alfred Ikehata Masateru Sasaki Hiroshi 《Journal of Infrared, Millimeter and Terahertz Waves》2022,43(3-4):260-271
Journal of Infrared, Millimeter, and Terahertz Waves - Millimeter waves (MMW) absorbed by skin or cornea may induce damage by heat. We have developed a 60 GHz MMW exposure-induced eye... 相似文献
4.
Adam Kłodowski Timo Rantalainen Aki Mikkola Ari Heinonen Harri Sievänen 《Multibody System Dynamics》2011,25(4):395-409
A method for bone strain estimation is examined in this article. The flexibility of a single bone in an otherwise rigid human
skeleton model has been studied previously by various authors. However, in the previous studies, the effect of the flexibility
of multiple bones on the musculoskeletal model behavior was ignored. This study describes a simulation method that can be
used to estimate the bone strains at both tibias and femurs of a 65-year-old Caucasian male subject. The verification of the
method is performed by the comparison of the results with other studies available in literature. The results of the study
show good correlation with the results of previous empirical studies. A damping effect of the flexible bones on the model
is also studied in this paper. 相似文献
5.
Simulation of complex mechatronic systems like an automobile, involving mechanical components as well as actuators and active
electronic control devices, can be accomplished by combining tools that deal with the simulation of the different subsystems.
In this sense, it is often desirable to couple a multibody simulation software (for the mechanical simulation) with external
numerical computing environments and block diagram simulators (for the modeling and simulation of nonmechanical components). 相似文献
6.
Jukka Vahlo Johanna K Kaakinen Suvi K. Holm Aki Koponen 《Journal of Computer-Mediated Communication》2017,22(2):88-103
In this study, we examine digital game preferences by identifying game dynamics, i.e. player–game interaction modes, of 700 contemporary digital games, and players' (N = 1717) desire to play games with specific types of dynamics. Based on statistical analysis of the data, 5 game dynamics preference categories (“assault,” “manage,” “journey,” “care,” and “coordinate”) and 7 player types were revealed. The results show that identifying player types requires including both preferred and undesired game dynamics categories in the analysis. The findings unveil digital gaming as a more multifaceted phenomenon than common stereotypes suggest. The original game preferences model we present in this study can be conceptualized as a complementary approach for motivations to play and player behavior studies. 相似文献
7.
Han Sekyung Aki Hirohisa Han Soohee Kwon Bokyu Park Jong-Bae 《International Journal of Control, Automation and Systems》2016,14(2):587-597
International Journal of Control, Automation and Systems - A practical charging strategy for an individual plug-in electric vehicle (PEV) is proposed. A cost function is constructed to reflect... 相似文献
8.
Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants
A. Araki I. Saito A. Kanazawa K. Morimoto K. Nakayama E. Shibata M. Tanaka T. Takigawa T. Yoshimura H. Chikara Y. Saijo R. Kishi 《Indoor air》2014,24(1):3-15
Organophosphate esters are used as additives in flame retardants and plasticizers, and they are ubiquitous in the indoor environment. Phosphorus flame retardants (PFRs) are present in residential dust, but few epidemiological studies have assessed their impact on human health. We measured the levels of 11 PFRs in indoor floor dust and multi‐surface dust in 182 single‐family dwellings in Japan. We evaluated their correlations with asthma and allergies of the inhabitants. Tris(2‐butoxyethyl) phosphate was detected in all samples (median value: 580 μg/g in floor dust, 111 μg/g in multi‐surface dust). Tris(2‐chloro‐iso‐propyl) phosphate (TCIPP) was detected at 8.69 μg/g in floor dust and 25.8 μg/g in multi‐surface dust. After adjustment for potential confounders, significant associations were found between the prevalence of atopic dermatitis and the presence of TCIPP and tris(1,3‐dichloro‐2‐propyl) phosphate in floor dust [per log10‐unit, odds ratio (OR): 2.43 and 1.84, respectively]. Tributyl phosphate was significantly associated with the prevalence of asthma (OR: 2.85 in floor dust, 5.34 in multi‐surface dust) and allergic rhinitis (OR: 2.55 in multi‐surface dust). PFR levels in Japan were high compared with values reported previously for Europe, Asia‐Pacific, and the USA. Higher levels of PFRs in house dust were related to the inhabitants' health status. 相似文献
9.
Suvi Santa-aho Minnamari Vippola Aki Sorsa Mari Lindgren Jyrki Latokartano Kauko Leiviskä Toivo Lepistö 《Journal of Materials Processing Technology》2012,212(11):2282-2293
Calibration samples for the Barkhausen noise (BN) method were produced with laser processing. A planet gear wheel used for production quality control was subjected to laser irradiation to verify the BN sensor output. Different samples were found to respond similarly to the laser processing although the laser parameters needed to be adjusted for different surface qualities separately. The surface optimization for laser processing was studied with different surface qualities of samples. The ground surface was compared with a sandblasted and vibratory ground surface. The ground and sandblasted surfaces were both amenable to the laser processing whereas the vibratory grinding process created inhomogeneous surfaces for laser beam absorption. Laser processing was found to produce uniform changes in the residual stress values in two perpendicular measuring directions. The root mean square value of the BN voltage signal exhibited linear correlations with the values of the residual stress and surface hardness. 相似文献
10.
The stability of seven reactive (one difluoromonochloropyrimidinyl and six monochlorotriazinyl) dyes on cellulose immersed in sodium peroxoborate (PB) solution (UK–TO solution) containing tetraacetylethylenediamine (TAED) was examined using cellulosic films at 60 °C. The extent of dye loss that occurred from the dyed cellulosic films which were immersed in the UK–TO solution without detergent correlated closely to the ratings obtained using the BS 1006 UK–TO wash test. The dye loss that occurred from the dyed cellophane films was attributed to three contributions, namely, alkaline hydrolysis of dye–fibre bonds, oxidative fading of the dye chromophore by peroxides and cellulose degradation accelerated by PB and TAED. The alkaline hydrolysis of the dye–fibre bond and the extent of cellulose degradation in the UK–TO solution were the main contributions to the dye loss; dye oxidation was a minor factor in the dye loss mechanism. The physical bonding of the dye molecules reinforced the covalent dye–fibre bond stability towards the UK–TO solution. 相似文献