Characterization of minocycline loaded chitosan/polyethylene glycol/glycerol blend films as antibacterial wound dressings

Wound care has been a challenging subject for medical teams and researchers. Bacterial infections are one of the most serious complications in injured skins that often affect healing process. Antibacterial wound dressings can be used to facilitate wound healing process. The purpose of this study is to fabricate chitosan (Chito)/polyethylene glycol (PEG) antibacterial wound dressing doped with minocycline, and to evaluate the influence of composition ratio on the blending properties of the films. To improve the mechanical properties of these films, we examined various amounts of glycerol as a plasticizer. Moreover, we investigated morphological and mechanical aspects, water uptake, degradation, water vapor transmission and wettability properties of the films prepared with various ratios of Chito/PEG/Gly. Assessment of mechanical properties revealed that film containing 80:20 ratio Chito/PEG with 40 PHR Gly content exhibits the highest ultimate tensile strength and elongation at break (9.74 MPa and 45.73% respectively). Furthermore, results demonstrated that upon increasing PEG and Gly contents, degradability and hydrophilicity of the films increased whereas water uptake decreased. Water vapor transmission rate of the films was close to the range of 530–1200 g/m²d, indicating that the as formed films are possible candidates for dressing low exudate wounds or burns. Minocycline loaded films exhibited a biphasic drug release profile and it was more effective on gram-positive bacteria than on gram-negative bacteria. The polymeric film with the highest amount of loaded drug (2%) exhibited insignificant cytotoxicity (88%) against normal fibroblast cell line.     

Radiation pattern design of photonic crystal LED optimized by using multi-objective grey wolf optimizer

Photonic Network Communications - This paper proposes an effective method for shaping the radiation pattern intensity of photonic crystal (PhC) light-emitting diode (LED). In this method, the...     

A novel numerical model of debonding of FRP-plated concrete beam

Accurate modeling is required to estimate the debonding in a plated fiber-reinforced polymer (FRP) concrete beam. In the present investigation, a numerical method is developed to model a crack in the FRP–concrete interface. An initial notch is located at the mid-span of the concrete beam. A modified crack closure integral method is implemented to model Mode-I fracture in the concrete. In the present research, a special interface element is formulated to simulate and to predict the distribution of interfacial shear stresses by using drilling degrees of freedom in the nodes of interface elements. Cohesive forces in the nodes of interface elements are formulated by finite element methods. A crack propagation criterion is presented to evaluate when the crack grows in FRP–concrete interface. If the principal stress in the node at the tip of an interface element reaches the maximum shear stress along the FRP–concrete interface, debonding happens. The model is robust, accurate, independent of mesh size, and it is able to model the crack growth in the concrete and debonding of the FRP–concrete interface, simultaneously. The model presented in this study showed acceptable similarity to previous research data.     

The role of hydrocolloids in the development of gluten-free cereal-based products for coeliac patients: a review

A growing number of diseases in association with gluten intake, such as coeliac disease, have led to increasing demand for gluten-free products as a crucial economic and health issue. Gluten-free products, because of the absence of gluten, usually have a poor texture, taste and appearance. Therefore, the production of good quality gluten-free products with substances that can somehow mimic the viscoelastic properties of gluten is an important challenge. Recently, hydrocolloids are widely used to improve the quality and shelf-life of gluten-free products. In this study, the effect of hydrocolloids on the production of gluten-free cereal-based products, such as breads, cakes and muffins, biscuits and cookies, pasta and noodles, has been reviewed as well as their nutritional values. In general, this study could suggest key factors in the improvement of gluten-free products.     

Dynamic modeling and base inertial parameters determination of a 2-DOF spherical parallel mechanism

This paper deals with the dynamic modeling and base inertial parameter determination of a general 5R 2-degree-of-freedom spherical parallel manipulator. By using a new geometric approach, inverse and forward kinematic problem are transformed to the problem of determining the intersection of two cones with common vertex. Compared to other proposed methods, this approach yields more compact and closed-form solutions. The instantaneous kinematic and acceleration problem is solved via employing the screw theory. The dynamic model is formulated by means of the principle of virtual work and the concept of link Jacobian matrices. In order to verify the proposed methods and equations, a case study is performed, in which an orthogonal 2-DOF spherical parallel manipulator, named TezGoz, is considered. Performed simulations and comparisons with a SimMechanics model show the correctness of the derived equations. Furthermore, a reduced dynamic model is obtained by determining the base inertial parameters. To do so, first the dynamic model is rewritten in a linear matrix form with respect to the inertial parameters of the mechanism, then parameters are grouped to obtain a set of independent base parameters, reducing the number of inertial parameters from 40 to 19. As a result, while maintaining the accuracy, the computational time is reduced to 63% of that of the original dynamic model. Finally, to calibrate the dynamic model, an experimental dynamic identification is performed.     

Bio‐lubricant flow behaviour in mini‐channels

One of the most common causes of failures in total joint replacements is the generation of wear particles within the joint. This contributes to bone lost and aseptic loosening of the implant, eventually requiring its replacement. Many studies have been carried out to improve the wear characteristics of bearing surfaces in total joint replacement. From the lubrication point of view, the friction behaviour of surfaces and rheology of the joint lubricant (synovial fluid) have been extensively studied. However, little attention has been paid to the interaction between the lubricant and the bearing surfaces. The aim of this study is to develop a methodology for studying the behaviour of bio‐based lubricant in mini‐channels. For this purpose, micro‐particle image velocimetry was used in order to characterise the lubricant behaviour. Channels made of relevant materials such as ultra‐high molecular weight polyethylene, cobalt–chromium–molybdenum alloy and titanium–aluminium–vanadium alloy with 1 and 1.5 mm width, 45 mm length and 2 mm depth were experimentally investigated. Results suggested that the used polymeric solution interaction with solid surfaces is very sensitive to the polymer concentration in the lubricant. Moreover, it was observed that there exist differences between water (Newtonian reference fluid) and the polymeric solution behaviour even at very simple movements; although usually, the properties of this lubricant at high shear rates are estimated by water properties. Copyright © 2015 John Wiley & Sons, Ltd.