Quantitative real-time imaging of myocardium based on ultrasonic integrated backscatter

The integrated backscatter calculation over the full, two-dimensional echocardiographic sector is implemented to produce images from closed-chest dogs. This new real-time integrated backscatter measurement system allows a continuous determination of integrated backscatter from all myocardial regions in the ultrasonic view. By replacing the conventional video processor in a commercial two-dimensional echocardiographic imager with this new real-time backscatter measurement system, it is possible to produce real-time two-dimensional images based on integrated backscatter.     

基于负载转矩观测器的动态恒风量控制

当前不基于外部传感器的恒风量控制技术的控制性能有限.针对此问题,提出一种基于负载转矩观测器的动态恒风量控制技术.构建降阶龙贝格负载转矩观测器,实现风机负载转矩及风道参数的实时观测,并进一步计算风压与风量.将实时计算的风量作闭环PI控制,形成风量-转速-电流三环控制.实测结果表明,所提出方法的风量控制精度高,且无需外部传感器,可有效兼顾实现低成本与高控制性能.     

基于负载转矩观测器的动态恒风量控制

当前不基于外部传感器的恒风量控制技术的控制性能有限.针对此问题,提出一种基于负载转矩观测器的动态恒风量控制技术.构建降阶龙贝格负载转矩观测器,实现风机负载转矩及风道参数的实时观测,并进一步计算风压与风量.将实时计算的风量作闭环PI控制,形成风量-转速-电流三环控制.实测结果表明,所提出方法的风量控制精度高,且无需外部传感器,可有效兼顾实现低成本与高控制性能.     

Bioactive IL7-diphtheria fusion toxin secreted by mammalian cells

A number of targeted cytotoxic agents have been developed that selectively kill malignant or otherwise pathological cells. These engineered proteins consist of a potent cytotoxic element connected to a ligand domain that binds to specific molecules on the surface of the target cell. Several of these agents have shown promise in clinical trials and one is currently administered to patients. A significant technical obstacle that has impeded the development of some of these toxins is the difficulty of preparing certain recombinant proteins in properly folded forms. These fusion proteins have generally been produced in bacteria requiring them to be denatured and renatured in vitro. For some proteins this is an efficient process whereas for others it is not. We describe here a system to produce fusion toxins rapidly and efficiently by engineering mammalian cells to secrete them as properly folded molecules which can be purified in native form from cell culture medium. We have used this system to produce highly active preparations of DAB(389)-IL7, a molecule consisting of the catalytic and transmembrane domains of diphtheria toxin fused to interleukin 7. This system is generalizable and can be used to produce and evaluate rapidly fusion toxins incorporating novel or uncharacterized ligands.     

基于排列熵和支持向量机的癫痫发作预测研究

针对癫痫发作给病人带来的巨大伤害,为临床治疗留下足够空余时间,提出一个可以预测癫痫发作的系统模型。对21名癫痫病人进行研究,提取具有较低算法复杂度的排列熵构成特征向量,将其输入支持向量机（support vector machine,SVM）训练出学习模型,用来识别发作期样本,利用投票机制充分考虑病人差异来判断所处状态,最终实现癫痫的实时预测。结果表明,其中81%的发作可以提前平均50多分钟预测到,且具有较低的误报率。为癫痫发作预测系统的理论研究打下坚实基础。     

Retention of heavy metals by stormwater filtration systems: breakthrough analysis

Biofiltration systems are widely used to mitigate the impacts of stormwater on receiving waters, however their long-term capacity to retain heavy metals has not previously been assessed. Accelerated-dosing laboratory experiments were used to assess the likelihood of breakthrough occurring for three different types of soil-based filter media that are commonly used in stormwater biofilters. In all cases, breakthrough of zinc (Zn) was observed, but not of cadmium (Cd), copper (Cu) and lead (Pb). If biofiltration systems are sized so that they are large relative to their catchment (at least 2-3% of its area) or have a deep filter layer (at least 0.5 m deep), then breakthrough will not occur for at least ten years and probably longer. However, after the equivalent of 12-15 years of operation, Cd, Cu and Zn had accumulated in the filter media to levels that exceeded human health and/or ecological guidelines. Further, depending on the design, it is possible that spent filter media may be classified as contaminated soil and thus require special disposal.