A charge sharing–based switching scheme for SAR ADCs

This paper presents an energy-efficient switching scheme for successive approximation register (SAR) analogue-to-digital converter (ADC). The proposed scheme employs charge recycling method to keep the capacitor arrays free of transitional energy between bit generations except reset phase. In comparison with the conventional switching scheme, the proposed one achieves 100% transitional energy saving without considering reset phase. In addition, configuration of a 10-bit SAR ADC shows that the proposed switching scheme reduces the capacitor area by 25% compared with the conventional switching scheme.     

K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma

Activation of K-ras gene by point mutations, a common finding in lung adenocarcinomas, has been suggested to decrease patient survival. We investigated 109 lung adenocarcinomas, mostly small, peripheral, stage I tumours (81/109) for presence of K-ras gene mutations at codons 12 and 13. Mutations were detected by denaturing gradient gel electrophoresis analysis of specific sequences amplified by polymerase chain reaction from DNA extracted from archival pathological material. Thirty-three of 109 (30.3%) tumours showed mutations at codon 12 (28/33, 84.8%) or 13 (5/33, 15.2%) of the gene. Mutations and type of nucleotide substitutions were differently distributed among cytological subtypes, being more prevalent among less differentiated (G2 and G3) tumours and among bronchial than bronchiolo-alveolar type adenocarcinomas. Survival analysis showed an adverse effect of K-ras mutation on survival, restricted to stage I tumours. Median survival for 81 stage I patients was 30 months for non-mutated tumours versus 20 months for mutated tumours (p = 0.016). Multivariate analysis showed that age of patient (p = 0.001) and K-ras mutation status (p = 0.04) were the only independent factors influencing survival significantly. These data strengthen the hypothesis that K-ras gene mutations may be useful in identifying a subgroup of patients with poor outcome.     

Laboratory examination of anisotropy in the foliation plane of metamorphic rocks

Mechanical testing and ultrasonic measurements were used to establish the properties of metamorphic rocks in different directions of the foliation plane. Tests were undertaken on 42 mm diameter specimens cored at right angles to the foliation of gneissic rocks from southwest Sweden. Ultrasonic and tensile testing was carried out in three diametral directions and the data for each direction were compared. Coefficients, failure load anisotropy and velocity anisotropy were obtained. An anisotropy coefficient of 3% was detected by ultrasonic measurements, while the Brazilian tests indicated 15%. The study has shown that an anisotropy coefficient of the foliation plane is present, albeit small. Electronic Publication     

A study on the mechanical strength of Fe2O3/Cr2O3/CuO catalyst for high temperature water gas shift reaction

Journal of Porous Materials - The present study aims to investigate the effects of iron (hydr)oxide phases formed during precipitation and the addition of different binders on the mechanical and...     

Simulation of reactive precipitation processes using the network-of-zones model

A 2-D network-of-zones model is extended and applied to a reactive precipitation process in batch mode. The simulations are performed for a network of size 2 × (10 × 10) for an elementary reaction through the solution of 1400 ODEs. The complicated interactions between mixing efficacy and the system kinetics are systematically investigated. When the stirrer speed is very slow, the crystal size distribution (CSD) of the product in the precipitator is determined by the intensity of mixing. Conversely, at higher stirrer speed, the CSD is controlled by the system kinetics. More effective mixing leads to an increase in the number of crystals, a reduction of the average size and a narrower crystal size distribution. The extended network-of-zones model presented in this work can be used conveniently for integrating computational fluid dynamics and reactive precipitation processes.     

HEAT TRANSFER IN A THIN LIQUID FILM IN THE PRESENCE OF AN ELECTRIC FIELD

Heat transfer enhancement in an evaporating thin liquid film utilizing a electric field under isothermal interfacial condition is presented. A new mathematical model subjected to van der Waals attractive forces, capillary pressure, and an electric field is developed to describe the heat transfer enhancement in the evaporating thin liquid film. The effect of the electrostatic field on the curvature of the thin film, evaporative flux, pressure gradient distribution, heat flux, and heat transfer coefficient in the thin film is presented. The results show that applying an electric field can enhance heat transfer in a thin liquid film significantly. In addition, utilizing electric fields on the evaporating film will be a way to expand the extended meniscus region to attain high heat transfer coefficients and high rates of heat flux.     

Natural killer or T-lymphocyte cells: Which is the best immune therapeutic agent for cancer? An optimal control approach

Therapeutic vaccines are being developed as a promising new approach to treatment for cancer patients. There are still many unanswered questions about which kind of therapeutic vaccines are the best for the cancer treatments? In this paper we consider a mathematical model, in the form of a system of ordinary differential equations (ODE), this system is an example from a class of mathematical models for immunotherapy of the tumor that were derived from a biologically validated model by Lisette G. de Pillis. The problem how to schedule a variable amount of which vaccines to achieve a maximum reduction in the primary cancer volume is consider as an optimal control problem and it is shown that optimal control is quadratic with 0 denoting a trajectory corresponding to no treatment and 1 a trajectory with treatment at maximum dose along that all therapeutics are being exhausted. The ODE system dynamics characterized by locating equilibrium points and stability properties are determined by using appropriate Lyapunov functions. Especially we attend a parametric sensitivity analysis, which indicates the dependency of the optimal solution with respect to disturbances in model parameters.     

Co-registered Frequency-Domain Photoacoustic Radar and Ultrasound System for Subsurface Imaging in Turbid Media

Frequency-domain photoacoustic radar (FD-PAR) imaging of absorbers in turbid media and their comparison and/or validation as well as co-registration with their corresponding ultrasound (US) images are demonstrated in this paper. Also presented are the FD-PAR tomography and the effects of reducing the number of scan lines (or angles) on image quality, resolution, and contrast. The FD-PAR modality uses intensity-modulated (coded) continuous wave laser sources driven by frequency-swept (chirp) waveforms. The spatial cross-correlation function between the PA response and the reference signal used for laser source modulation produces the reconstructed image. Live animal testing is demonstrated, and images of comparable signal-to-noise ratio, contrast, and spatial resolution were obtained. Various image improvement techniques to further reduce absorber spread and artifacts in the images such as normalization, filtering, and amplification were also investigated. The co-registered image produced from the combined US and PA images provides more information than both images independently. The significance of this work lies in the fact that achieving PA imaging functionality on a commercial ultrasound instrument could accelerate its clinical acceptance and use. This work is aimed at functional PA imaging of small animals in vivo.     

Investigation of Ablation Efficiency of Stainless Steel Using Pulsed Lasers in Burst Mode

Due to its high corrosion resistance and mechanical properties, stainless steel is commonly used in various industrial applications. Although different types of stainless steel are similar in their chemical composition, they can differ significantly in their thermal diffusivity. This property is relevant in the ability of a material to conduct heat and thus, in laser processing. In this frame, this study compares the ablation efficiency and characteristics of polished stainless steel samples of the alloys AISI 304, AISI 420, and AISI 316Ti. They are irradiated with single ultrashort pulses having pulse durations between 250 fs and 10 ps as well as using GHz burst modii. The goal is to investigate the differences in both the ablation threshold and the ablation rate to improve the ablation efficiency. The results show that shorter pulse durations lead to a more efficient ablation process. On the other hand, GHz bursts are found to be, in general, less efficient. In addition, there is a significant difference in the surface morphology depending on the process parameters. The differences in the thermal diffusivity do not significantly influence the ablation threshold fluence but surface morphology and the ablation rate.     

A novel TFT‐OLED integration for OLED‐independent pixel programming in amorphous‐Si AMOLED pixels

Abstract— The direct voltage programming of active‐matrix organic light‐emitting‐diode (AMOLED) pixels with n‐channel amorphous‐Si (a‐Si) TFTs requires a contact between the driving TFT and the OLED cathode. Current processing constraints only permit connecting the driving TFT to the OLED anode. Here, a new “inverted” integration technique which makes the direct programming possible by connecting the driver n‐channel a‐Si TFT to the OLED cathode is demonstrated. As a result, the pixel drive current increases by an order of magnitude for the same data voltages and the pixel data voltage for turn‐on drops by several volts. In addition, the pixel drive current becomes independent of the OLED characteristics so that OLED aging does not affect the pixel current. Furthermore, the new integration technique is modified to allow substrate rotation during OLED evaporation to improve the pixel yield and uniformity. The new integration technique is important for realizing active‐matrix OLED displays with a‐Si technology and conventional bottom‐anode OLEDs.