全文获取类型
收费全文 | 84727篇 |
免费 | 1091篇 |
国内免费 | 409篇 |
专业分类
电工技术 | 774篇 |
综合类 | 2316篇 |
化学工业 | 11752篇 |
金属工艺 | 4788篇 |
机械仪表 | 3036篇 |
建筑科学 | 2191篇 |
矿业工程 | 566篇 |
能源动力 | 1142篇 |
轻工业 | 3982篇 |
水利工程 | 1275篇 |
石油天然气 | 351篇 |
无线电 | 9285篇 |
一般工业技术 | 16410篇 |
冶金工业 | 2718篇 |
原子能技术 | 257篇 |
自动化技术 | 25384篇 |
出版年
2023年 | 16篇 |
2022年 | 84篇 |
2021年 | 96篇 |
2020年 | 32篇 |
2019年 | 53篇 |
2018年 | 14487篇 |
2017年 | 13407篇 |
2016年 | 10006篇 |
2015年 | 642篇 |
2014年 | 277篇 |
2013年 | 262篇 |
2012年 | 3224篇 |
2011年 | 9478篇 |
2010年 | 8331篇 |
2009年 | 5593篇 |
2008年 | 6830篇 |
2007年 | 7830篇 |
2006年 | 159篇 |
2005年 | 1242篇 |
2004年 | 1153篇 |
2003年 | 1196篇 |
2002年 | 548篇 |
2001年 | 102篇 |
2000年 | 187篇 |
1999年 | 64篇 |
1998年 | 85篇 |
1997年 | 49篇 |
1996年 | 56篇 |
1995年 | 23篇 |
1994年 | 25篇 |
1993年 | 25篇 |
1992年 | 13篇 |
1991年 | 28篇 |
1988年 | 10篇 |
1969年 | 24篇 |
1968年 | 43篇 |
1967年 | 33篇 |
1966年 | 42篇 |
1965年 | 44篇 |
1964年 | 11篇 |
1963年 | 28篇 |
1962年 | 22篇 |
1961年 | 18篇 |
1960年 | 30篇 |
1959年 | 35篇 |
1958年 | 37篇 |
1957年 | 36篇 |
1956年 | 34篇 |
1955年 | 63篇 |
1954年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Vanessa Modelski Schatkoski Thaís Larissa do Amaral Montanheiro Beatriz Rossi Canuto de Menezes Raissa Monteiro Pereira Karla Faquine Rodrigues Renata Guimarães Ribas Diego Morais da Silva Gilmar Patrocínio Thim 《Ceramics International》2021,47(3):2999-3012
Studies related to biomaterials that stimulate the repair of living tissue have increased considerably, improving the quality of many people's lives that require surgery due to traumatic accidents, bone diseases, bone defects, and reconstructions. Among these biomaterials, bioceramics and bioactive glasses (BGs) have proved to be suitable for coating materials, cement, scaffolds, and nanoparticles, once they present good biocompatibility and degradability, able to generate osteoconduction on the surrounding tissue. However, the role of biomaterials in hard tissue engineering is not restricted to a structural replacement or for guiding tissue regeneration. Nowadays, it is expected that biomaterials develop a multifunctional role when implanted, orchestrating the process of tissue regeneration and providing to the body the capacity to heal itself. In this way, the incorporation of specific metal ions in bioceramics and BGs structure, including magnesium, silver, strontium, lithium, copper, iron, zinc, cobalt, and manganese are currently receiving enhanced interest as biomaterials for biomedical applications. When an ion is incorporated into the bioceramic structure, a new category of material is created, which has several unique properties that overcome the disadvantages of primitive material and favors its use in different biomedical applications. The doping can enhance handling properties, angiogenic and osteogenic performance, and antimicrobial activity. Therefore, this review aims to summarize the effect of selected metal ion dopants into bioceramics and silicate-based BGs in bone tissue engineering. Furthermore, new applications for doped bioceramics and BGs are highlighted, including cancer treatment and drug delivery. 相似文献
2.
Myriam Gonzlez María Ovejero-Snchez Alba Vicente-Blzquez Raquel lvarez Ana B. Herrero Manuel Medarde Rogelio Gonzlez-Sarmiento Rafael Pelez 《International journal of molecular sciences》2021,22(4)
Pan-Gyn cancers entail 1 in 5 cancer cases worldwide, breast cancer being the most commonly diagnosed and responsible for most cancer deaths in women. The high incidence and mortality of these malignancies, together with the handicaps of taxanes—first-line treatments—turn the development of alternative therapeutics into an urgency. Taxanes exhibit low water solubility that require formulations that involve side effects. These drugs are often associated with dose-limiting toxicities and with the appearance of multi-drug resistance (MDR). Here, we propose targeting tubulin with compounds directed to the colchicine site, as their smaller size offer pharmacokinetic advantages and make them less prone to MDR efflux. We have prepared 52 new Microtubule Destabilizing Sulfonamides (MDS) that mostly avoid MDR-mediated resistance and with improved aqueous solubility. The most potent compounds, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methylaminobenzenesulfonamide 38, N-methyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 42, and N-benzyl-N-(3,4,5-trimethoxyphenyl-4-methoxy-3-aminobenzenesulfonamide 45 show nanomolar antiproliferative potencies against ovarian, breast, and cervix carcinoma cells, similar or even better than paclitaxel. Compounds behave as tubulin-binding agents, causing an evident disruption of the microtubule network, in vitro Tubulin Polymerization Inhibition (TPI), and mitotic catastrophe followed by apoptosis. Our results suggest that these novel MDS may be promising alternatives to taxane-based chemotherapy in chemoresistant Pan-Gyn cancers. 相似文献
3.
Mobile software applications have to cope with a particular environment that involves small size, limited resources, high autonomy requirements, competitive business models and many other challenges. To provide development guidelines that respond to these needs, several practices have been introduced; however, it is not clear how these guidelines may contribute to solve the issues present in the mobile domain. Furthermore, the rapid evolution of the mobile ecosystem challenges many of the premises upon which the proposed practices were designed. In this paper, we present a survey of the literature on software assurance practices for mobile applications, with the objective of describing them and assessing their contribution and success. We identified, organized and reviewed a body of research that spans in three levels: software development processes, software product assurance practices, and software implementation practices. By carrying out this literature survey, we reviewed the different approaches that researchers on Software Engineering have provided to address the needs that raise in the mobile software development arena. Moreover, we review the evolution of these practices, identifying how the constant changes and modernization of the mobile execution environment has impacted the methods proposed in the literature. Finally, we introduced discussion on the application of these practices in a real productive setting, opening an area for further research that may determine if practitioners have followed the proposed assurance paradigms. 相似文献
4.
This paper presents an integrated passive damping approach in hybrid metal-CFRP parts for structural applications. In this concept a viscoelastic material is embedded in the joint zone of the hybrid component. To examine the connection strength single-lap-joint specimens were produced and tested and the influence of the used material combinations, different surface structures, and different process parameters i.e. the moment of cross-linking were evaluated. Afterwards, the metal-CFRP hybrids were tested in quasi-static tests to assess their connection strength and failure behaviour. Dynamic cyclic tensile tests with step-wise increased loading conditions were performed to determine the specimens damping behaviour and to estimate their fatigue performance. Finally, these results are compared to a state of the art metal-CFRP hybrid with rivets connecting both materials. 相似文献
5.
In this paper, we consider the classical finite mixture model, which is an effective tool for modeling lifetime distributions for random samples from heterogeneous populations. We discuss new results on stochastic comparison for two finite mixtures when each of them is drawn from one of the following semiparametric families, i.e., proportional hazards, accelerated lifetime and proportional reversed hazards. 相似文献
6.
7.
8.
Variations of Incomplete Open Cubes is the major project by the twentieth-century conceptual artist Sol LeWitt. In this paper we interpret the enumerative component of the project as embeddings of graphs. This formulation permits use of an algorithm to check the completeness of the list of the structures produced by the artist. Our conclusion is that the artist found the correct number of structures (that is, 122), but that his list contains a mistake in the presentation of a pair of incomplete cubes, a discovery that appears not to have been noted before. 相似文献
9.