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Zusammenfassung Es wird über Sulfonamidbefunde in Nieren und Muskulatur geschlachteter Tiere (36 Rinder, 3 Schweine) berichtet. Gewebeproben wurden vor und nach der Gewebefraktionierung mit einem durch Trimethoprim modifizierten Hemmstofftest (Teststamm:Bac. subtilis BGA) auf Hemmaktivität sowie mit einer dünnschichtchromatographischen Methode (DC) auf Sulfonamide untersucht. Als Indikatorreakti on für die Darstellung der Sulfonamide diente deren Derivatisierung mit Fluorescamin (Fluram) nach zweidimensionaler Trennung. Insgesamt wurden 11 verschiedene Sulfonamide identifiziert. An Hand von Dosis-Wirkungsbeziehungen wurde gezeigt, daß das mit Trimethoprim modifizierte Testsystem mit Ausnahme der enteral angewandten und kaum absorbierbaren Substanzen allen sonst untersuchten Sulfonamiden gegenüber mittel- bis hochgradig sensitiv ist. Hierbei liegt die minimale Hemmkonzentration im Agarlochtest (50 l) zwischen 10 und 25 Nanogramm je Sulfonamid. Der Vergleich der Ergebnisse von mikrobiologischem Test und chemischer Analyse zeigte bei dem vorliegenden Untersuchungsmaterial, daß knapp 30% der mit dem modifizierten Hemmstofftest positiv reagierenden Nierenproben aufgrund des DC-Befundes nicht als sulfonamidhaltig anzusehen waren, während umgekehrt bei den Muskelproben nahezu 30% der mit Hilfe der DC als sulfonamidhaltig erkannten Proben durch den mikrobiologischen Test nicht erfaßt wurden.
Analysis of sulfonamides in tissues of slaughtered animals. Comparison of results from a microbiological test and from thin layer chromatographic analysis after derivatization with fluorescamin
Summary Sulfonamide residues in kidneys and muscles of slaughtered animals (36 cattle, 3 pigs) are reported. Tissue samples were examined prior to and after separation first for inhibitory activity by an inhibition test modified by addition of trimethoprim and subsequently for sulfonamides by thin layer chromatography (TLC). Sulfonamides were demonstrated by derivatisation with fluorescamine (Fluram) after two dimensional separation. A total of 11 different sulfonamides was identified. It could be demonstrated by dosage-activity relationships that the test system modified with trimethoprim was moderately to highly sensitive to all examined sulfonamides with the exception of the enterally applied and hardly absorbable substances. In this test (agar diffusion test, 50 l per well) the minimal inhibotory concentration is between 10 and 25 ng for each of the sulfonamides. Comparing the microbiological test with the chemical analysis it could be demonstrated that nearly 30% of the kidney samples which were positive in the modified inhibition test did not contain sulfonamides according to interpretation of the TLC. On the other hand nearly 30% of the muscle samples containing sulfonamides (found by TLC) did not react to the microbiological test.
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Electron traps in low-temperature-grown ~40-nm-thick GaAs layers containing nanometer As-Sb clusters have been studied using deep-level transient spectroscopy. Measurements at various bias voltages and small-amplitude filling pulses have allowed the identification of two groups (T1 and T2) of traps with substantially different thermal electron emission rates. It is shown that the density of traps T2 (with an activation energy of 0.56 ± 0.04 eV and electron capture cross section of 2 × 10?13?10?12cm2) is ~2 × 1012cm?2, while the density of traps T1 (0.44 ± 0.02 eV and 2 × 10?14?10?13 cm2, respectively) is ten times lower. It is assumed that, according to the existence of the two cluster groups observed in the layers under study, traps T2 are associated with clusters 4–7 nm in diameter and traps T1, with clusters up to ~20 nm in diameter.  相似文献   
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Device degradation modelling is more and more important for reliable circuit design. On MOSFET, the threshold voltage drift in time can lead to circuit performance degradation. In this study, VT shift due to Hot Carrier Injection stress is accelerated on small width devices. VT matching is also degraded during stress as a function of VT deterioration. This width dependence allows explaining gate voltage matching behavior in the sub-threshold area used in low power analog applications.  相似文献   
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Electron-microscopy studies of GaAs structures grown by the method of molecular-beam epitaxy and containing arrays of semiconductor InAs quantum dots and metallic As quantum dots are performed. An array of InAs quantum dots is formed using the Stranski-Krastanow mechanism and consists of five layers of vertically conjugated quantum dots divided by a 5-nm-thick GaAs spacer layer. The array of As quantum dots is formed in an As-enriched GaAs layer grown at a low temperature above an array of InAs quantum dots using postgrowth annealing at temperatures of 400–600°C for 15 min. It is found that, during the course of structure growth near the InAs quantum dots, misfit defects are formed; these defects are represented by 60° or edge dislocations located in the heterointerface plane of the semiconductor quantum dots and penetrating to the surface through a layer of “low-temperature” GaAs. The presence of such structural defects leads to the formation of As quantum dots in the vicinity of the middle of the InAs conjugated quantum dots beyond the layer of “low-temperature” GaAs.  相似文献   
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This paper reports a novel remotely actuated manipulator for access to prostate tissue under magnetic resonance imaging guidance (APT-MRI) device, designed for use in a standard high-field MRI scanner. The device provides three-dimensional MRI guided needle placement with millimeter accuracy under physician control. Procedures enabled by this device include MRI guided needle biopsy, fiducial marker placements, and therapy delivery. Its compact size allows for use in both standard cylindrical and open configuration MRI scanners. Preliminary in vivo canine experiments and first clinical trials are reported.  相似文献   
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许多便携式应用需要超过8kV的ESD保护,同时将电容保持在5pF以下。Z二极管能够单独满足这一要求,但当与开关或结型二极管等低电容PN二极管相结合时,它们可同时满足该应用的以下两种要求:低电容,以及高ESD和  相似文献   
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Mechanisms of InGaAlAs solid solution decomposition stimulated by a purposely deposited layer of InAs quantum dots are studied. Decomposition of the solid solution results in an increase in the effective quantum dot size and the shift of the photoluminescence line to as far as 1.3 μm. When aluminum atoms are added to the solid solution, the effect of In atom “conservation” within the dots is observed, which also causes an increase in the effective dot size. __________ Translated from Fizika i Tekhnika Poluprovodnikov, Vol. 34, No. 3, 2000, pp. 330–333. Original Russian Text Copyright ? 2000 by Tsatsul’nikov, Volovik, Bedarev, Zhukov, Kovsh, Ledentsov, Maksimov, Maleev, Musikhin, Ustinov, Bert, Kop’ev, Bimberg, Alferov.  相似文献   
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