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Silicon - This work presents the analog and RF performance evaluation of Junctionless Accumulation Mode (JAM) Gate Stack Gate All Around (GS-GAA) FinFET, and the results acquired have been compared... 相似文献
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The most common alarming and dangerous disease in the world today is the coronavirus disease 2019 (COVID-19). The coronavirus is perceived as a group of coronaviruses which causes mild to severe respiratory diseases among human beings. The infection is spread by aerosols emitted from infected individuals during talking, sneezing, and coughing. Furthermore, infection can occur by touching a contaminated surface followed by transfer of the viral load to the face. Transmission may occur through aerosols that stay suspended in the air for extended periods of time in enclosed spaces. To stop the spread of the pandemic, it is crucial to isolate infected patients in quarantine houses. Government health organizations faced a lack of quarantine houses and medical test facilities at the first level of testing by the proposed model. If any serious condition is observed at the first level testing, then patients should be recommended to be hospitalized. In this study, an IoT-enabled smart monitoring system is proposed to detect COVID-19 positive patients and monitor them during their home quarantine. The Internet of Medical Things (IoMT), known as healthcare IoT, is employed as the foundation of the proposed model. The least-squares (LS) method was applied to estimate the linear model parameters for a sequential pilot survey. A statistical sequential analysis is performed as a pilot survey to efficiently collect preliminary data for an extensive survey of COVID-19 positive cases. The Bayesian approach is used, based on the assumption of the random variable for the priori distribution of the data sample. Fuzzy inference is used to construct different rules based on the basic symptoms of COVID-19 patients to make an expert decision to detect COVID-19 positive cases. Finally, the performance of the proposed model was determined by applying a four-fold cross-validation technique. 相似文献
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Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library 下载免费PDF全文
Dr. Andrew Woodland Dr. Stephen Thompson Dr. Laura A. T. Cleghorn Dr. Neil Norcross Dr. Manu De Rycker Dr. Raffaella Grimaldi Irene Hallyburton Dr. Bhavya Rao Suzanne Norval Laste Stojanovski Prof. Reto Brun Dr. Marcel Kaiser Prof. Julie A. Frearson Dr. David W. Gray Prof. Paul G. Wyatt Dr. Kevin D. Read Prof. Ian H. Gilbert 《ChemMedChem》2015,10(11):1809-1820
A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed >50 % inhibition at 5 μm . Screening of these hits in a T. b. brucei proliferation assay highlighted three compounds with a 1H‐imidazo[4,5‐b]pyrazin‐2(3H)‐one scaffold that showed sub‐micromolar activity and excellent selectivity against the MRC5 cell line. Subsequent rounds of optimisation led to the identification of compounds that exhibited good in vitro drug metabolism and pharmacokinetics (DMPK) properties, although in general this series suffered from poor solubility. A scaffold‐hopping exercise led to the identification of a 1H‐pyrazolo[3,4‐b]pyridine scaffold, which retained potency. A number of examples were assessed in a T. b. brucei growth assay, which could differentiate static and cidal action. Compounds from the 1H‐imidazo[4,5‐b]pyrazin‐2(3H)‐one series were found to be either static or growth‐slowing and not cidal. Compounds with the 1H‐pyrazolo[3,4‐b]pyridine scaffold were found to be cidal and showed an unusual biphasic nature in this assay, suggesting they act by at least two mechanisms. 相似文献
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Cover Picture: Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015) 下载免费PDF全文
Daniel Spinks Victoria Smith Dr. Stephen Thompson Dr. David A. Robinson Dr. Torsten Luksch Alasdair Smith Dr. Leah S. Torrie Dr. Stuart McElroy Laste Stojanovski Suzanne Norval Iain T. Collie Irene Hallyburton Bhavya Rao Dr. Stephen Brand Dr. Ruth Brenk Prof. Julie A. Frearson Dr. Kevin D. Read Prof. Paul G. Wyatt Prof. Ian H. Gilbert 《ChemMedChem》2015,10(11):1769-1769
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Bhavya Panikuttira Fred A. Payne Norah O'Shea John T. Tobin Donal J. O'Callaghan Colm P. O'Donnell 《International Journal of Food Science & Technology》2020,55(1):175-182
Coagulation of milk is one of the most important steps in cheese manufacture. Cutting the coagulum at optimum firmness is important to optimise the yield and quality of the cheese produced. The aim of this study was to investigate a prototype sensor to monitor rennet-induced coagulation of skim milk at different protein concentrations (3.3%, 4.0% and 4.7%) and to develop a model to predict the coagulum cutting time at a desired storage modulus (G′). Fluorescence and infrared backscatter profiles were recorded at wavelengths of 350 and 880 nm, respectively. Rheological measurements were used as a reference method to determine the times required for the coagulum to reach G′ values of 0.5, 5 and 20 Pa. Time parameters extracted from the optical profiles generated during the coagulation process were used to develop a model to predict the cutting time at which the coagulum reaches selected G′ values. This study demonstrated that the investigated prototype sensor, combined with the developed prediction model, can be used as an in-line PAT tool for real-time monitoring of milk coagulation and prediction of cutting time in cheese manufacturing. 相似文献
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Development of Small‐Molecule Trypanosoma brucei N‐Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode 下载免费PDF全文
Daniel Spinks Victoria Smith Dr. Stephen Thompson Dr. David A. Robinson Dr. Torsten Luksch Alasdair Smith Dr. Leah S. Torrie Dr. Stuart McElroy Laste Stojanovski Suzanne Norval Iain T. Collie Irene Hallyburton Bhavya Rao Dr. Stephen Brand Dr. Ruth Brenk Prof. Julie A. Frearson Dr. Kevin D. Read Prof. Paul G. Wyatt Prof. Ian H. Gilbert 《ChemMedChem》2015,10(11):1821-1836
The enzyme N‐myristoyltransferase (NMT) from Trypanosoma brucei has been validated both chemically and biologically as a potential drug target for human African trypanosomiasis. We previously reported the development of some very potent compounds based around a pyrazole sulfonamide series, derived from a high‐throughput screen. Herein we describe work around thiazolidinone and benzomorpholine scaffolds that were also identified in the screen. An X‐ray crystal structure of the thiazolidinone hit in Leishmania major NMT showed the compound bound in the previously reported active site, utilising a novel binding mode. This provides potential for further optimisation. The benzomorpholinone was also found to bind in a similar region. Using an X‐ray crystallography/structure‐based design approach, the benzomorpholinone series was further optimised, increasing activity against T. brucei NMT by >1000‐fold. A series of trypanocidal compounds were identified with suitable in vitro DMPK properties, including CNS exposure for further development. Further work is required to increase selectivity over the human NMT isoform and activity against T. brucei. 相似文献
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Yunlu Zhao Mysore Lokesh Bhavya Apurva Patange Da-Wen Sun Brijesh K. Tiwari 《Comprehensive Reviews in Food Science and Food Safety》2023,22(3):1654-1685
Plasma-activated liquids (PALs) are emerging and promising alternatives to traditional decontamination technologies and have evolved as a new technology for applications in food, agriculture, and medicine. Contamination caused by foodborne pathogens and their biofilms has posed challenges and concerns to the food industry in terms of safety and quality. The nature of the food and the food processing environment are major factors that contribute to the growth of various microorganisms, followed by the biofilm characteristics that ensure their survival in severe environmental conditions and against traditional chemical disinfectants. PALs show an efficient impact against microorganisms and their biofilms, with various reactive species (short- and long-lived ones), physiochemical properties, and plasma processing factors playing a crucial role in mitigating biofilms. Moreover, there is potential to improve and optimize disinfection strategies using a combination of PALs with other technologies for the inactivation of biofilms. The overarching aim of this study is to build a better understanding of the parameters that govern the liquid chemistry generated in a liquid exposed to plasma and how these translate into biological effects on biofilms. This review provides a current understanding of PALs-mediated mechanisms of action on biofilms; however, the precise inactivation mechanism is still not clear and is an important part of the research. Implementation of PALs in the food industry could help overcome the disinfection hurdles and can enhance biofilm inactivation efficacy. Future perspectives in this field to expand existing state of the art to seek breakthroughs for scale-up and implementation of PALs technology in the food industry are also discussed. 相似文献