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排序方式: 共有1305条查询结果,搜索用时 12 毫秒
1.
M Valenti G Cimoli S Parodi GL Mariani M Venturini P Conte P Russo 《Canadian Metallurgical Quarterly》1993,(8):1157-1161
Synergism between recombinant human tumour necrosis factor (rHuTNF) and DNA topoisomerase II inhibitor VP16 during the killing of cells has been studied in six human ovarian cancer cell lines (A2774, A2780, SW626, IGROV-1, SKOV3, Pa1) and a cervical carcinoma cell line (Me180). Studies were performed using an assay of colony formation inhibition (drug treatment for 1 h) and a growth inhibition assay (continuous exposure for 20 h). Concomitant treatment of cells with VP16+rHuTNF enhanced cell killing in all the cell lines tested--an effect observed in both short- and long-term cytotoxicity assays. This study suggests that the activity of VP16 in ovarian cancer cell lines might be enhanced by rHuTNF in in vitro models. 相似文献
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As the number of fuzzy logic applications increases, demand for faster architectures will grow. Our design for a VLSI fuzzy processor uses fuzzy inference techniques that optimize processing time. Preprocessing that reduces the number of rules to be processed, parallel computation of active rule degrees of activation, and scalability are major features of this architecture. The journal issue contains a concise summary of this article. The complete article is linked to Micro's home page on the World Wide Web (http://www.computer.org/pubs/micro/micro.htm) 相似文献
4.
Carlos A. Felippa Bjrn Haugen Carmelo Militello 《International journal for numerical methods in engineering》1995,38(2):199-229
This paper starts a sequence of three articles that follow an unconventional approach in finite element research. The ultimate objective is to construct high-performance elements and element-level error estimators for those elements. The approach takes off from our previous work in high-performance elements and culminates with the development of finite element templates. The present paper concentrates on the patch test and evolved versions of the test that have played a key role in this research. Following a brief review of the historical roots, we present the Individual Element Test (IET) of Bergan and Hanssen in an expanded context that encompasses several important classes of new elements. The relationship of the IET to the multielement forms A, B and C of the patch test and to the single-element test are investigated. An important consequence of the IET application is that the element stiffness equations decompose naturally into basic and higher-order parts. The application of this decomposition to the “sanitization” of the non-convergent BCIZ element is described and verified with numerical experiments. Two sequel papers in preparation are subtitled ‘the algebraic approach’ and ‘element-level error estimation’. These apply the fundamental decomposition to the derivation of templates for specific mechanical elements and to the construction of element-level error estimators, respectively. 相似文献
5.
The ultrastructural diagnosis of tumors requires a careful analysis that should be done in an orderly fashion. It requires precise planning from the time of specimen collection to the selection of the area to be examined. Pictures must be taken systematically and every micrograph should allow to answer whether the number of cells photographed is adequate; whether mitoses are present, what is the pattern of the tumor; what is the appearance of the cell membrane; whether the cells are joined by junctional complexes; whether free surfaces possess microvilli or cilia; what organelles are present and how they are distributed; whether there are secretory granules, melanosomes, or other cytoplasmic elements. Nuclear and nucleolar size and shape have to be taken into consideration. The composition of the interstitial extracellular matrix is important in certain types of tumors. Although these questions are not the only ones to be addressed, their use in a logical fashion is helpful when it concerns the ultrastructural diagnosis. 相似文献
6.
MG Narducci L Virgilio JB Engiles AM Buchberg L Billips A Facchiano CM Croce G Russo JL Rothstein 《Canadian Metallurgical Quarterly》1997,15(8):919-926
In human leukemias and lymphomas nonrandom chromosomal rearrangements cause changes in cell growth and/or survival in such a way as to promote malignancy. The detailed study of the biochemical and genetic pathways altered in human cancer requires the identification or development of models to allow the study and manipulation of cancer gene function. Recently, the breakpoint gene TCL1, involved in chromosome translocations observed mostly in mature T-cell proliferations and chronic lymphocytic leukemias (CLL), was isolated and characterized, and showed to be part of a new gene family of proteins involved in these tumors. The murine Tcl1 gene, is similar in sequence to the murine and human MTCP1 gene also involved in T cell leukemias. The murine Tcl1 gene was shown to reside on mouse chromosome 12 in a region syntenic to human chromosome 14. Furthermore, we show that the murine Tcl1 gene is expressed early in mouse embryonic development and demonstrates expression in fetal hematopoietic organs as well as in immature T and B cells. Characterization of the murine Tcl1 gene will help in developing a mouse model of CLL and would provide the best opportunity to study and decipher the role of TCL1 in malignant transformation. 相似文献
7.
A satellite system based on the frequency scanning concept has been recently assessed for L‐band land mobile communications.
The study – promototed by ESA/ESTEC for an European application mission – has reached an advanced electrical design phase.
The selected configuration is particularly advantageous in terms of Carrier‐to‐Intermodulation ratio (C/I) performance, which
constitutes a requirement of key‐importance in the envisaged user applications. The advantage in C/I is due to the proper
choice of the on‐board transmitter configuration, which adopts power module pairs where the overall power demand is evenly
distributed. The consequent improved C/I is then achievable at both transmitter and radiated far field level. The present
paper aims a contribution to the design methodology of frequency scanning satellite systems, by joining two key‐aspects: in
fact an analytical approach is proposed to demonstrate the C/I advantage achievable through frequency scanning satellite systems
and the methodology is applied to a concrete example, the ESA/ESTEC system, whose feasibility has been fully proved in previous
studies. The analysis is performed both at transmitter level and in the far field. The main results achieved are hereinafter
presented.
This revised version was published online in June 2006 with corrections to the Cover Date. 相似文献
8.
Angela Altomare Carmelo Giacovazzo Anna Grazia Giuseppina Moliterni Rosanna Rizzi 《Journal of research of the National Institute of Standards and Technology》2004,109(1):125-132
The ab-initio crystal structure solution by powder diffraction data requires great efforts because of the collapse of the experimental information onto the one dimensional 2θ axis of the pattern. Different strategies will be described aiming at improving the process of extraction of the integrated intensities from the experimental pattern in order to make more straightforward the structure solution process by direct methods. Particular attention will be devoted to the EXPO program. Some of its performance will be analysed and results will be shown. 相似文献
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Welch G. State A. Ilie A. Kok-Lim Low Lastra A. Cairns B. Towles H. Fuchs H. Ruigang Yang Becker S. Russo D. Funaro J. van Dam A. 《Multimedia, IEEE》2005,12(3):22-35
Immersive electronic books (IEBooks) for surgical training will let surgeons explore previous surgical procedures in 3D. The authors describe the techniques and tools for creating a preliminary IEBook, embodying some of the basic concepts. 相似文献