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排序方式: 共有377条查询结果,搜索用时 15 毫秒
1.
Akiko Suzuki Mina Minamide Chihiro Iwaya Kenichi Ogata Junichi Iwata 《International journal of molecular sciences》2020,21(23)
Carbohydrates, fats, and proteins are the underlying energy sources for animals and are catabolized through specific biochemical cascades involving numerous enzymes. The catabolites and metabolites in these metabolic pathways are crucial for many cellular functions; therefore, an imbalance and/or dysregulation of these pathways causes cellular dysfunction, resulting in various metabolic diseases. Bone, a highly mineralized organ that serves as a skeleton of the body, undergoes continuous active turnover, which is required for the maintenance of healthy bony components through the deposition and resorption of bone matrix and minerals. This highly coordinated event is regulated throughout life by bone cells such as osteoblasts, osteoclasts, and osteocytes, and requires synchronized activities from different metabolic pathways. Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies. 相似文献
2.
Chihiro J. Uchibori Y. Ohtani T. Oku Naoki Ono Masanori Murakami 《Journal of Electronic Materials》1997,26(4):410-414
Significant reduction of the contact resistance of In0.7Ga0.3As/Ni/W contacts (which were previously developed by sputtering in our laboratory) was achieved by depositing a W2N barrier layer between the Ni layer and W layer. The In0.7Ga0.3 As/Ni/W2N/W contact prepared by the radio-frequency sputtering technique showed the lowest contact resistance of 0.2 Ωmm after annealing
at 550°C for 10 s. This contact also provided a smooth surface, good reproducibility, and excellent thermal stability at 400°C.
The polycrystalline W2N layer was found to suppress the In diffusion to the contact surface, leading to improvement of the surface morphology and
an increase in the total area of the InxGa−As between metal and the GaAs substrate. These improvements are believed to reduce the contact resistance. 相似文献
3.
Koji Yamada Noboru Miura Chihiro Hamaguchi Norihiko Kamata 《Solid-state electronics》1989,32(12):1113-1117
Hot carrier magnetophonon resonances of n-type Si, short channel InP and p-type InSb were investigated in pulsed high magnetic fields up to 40 T. Using a recently developed high resolution technique in pulsed high fields, many new features of the hot carrier-phonon interactions in high magnetic fields were found. 相似文献
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Sun-Chan Jeong Ichiro Katayama Hirokane Kawakami Yutaka Watanabe Hironobu Ishiyama Nobuaki Imai Yoshikazu Hirayama Hiroari Miyatake Masao Sataka Satoru Okayasu Hiroyuki Sugai Shin-Ichi Ichikawa Katsuhisa Nishio Shinichi Mitsuoka Takamitsu Nakanoya Masahito Yahagi Takanori Hashimoto Kazunori Takada Mamoru Watanabe Tomoko Ishikawa Akihiro Iwase 《Journal of Phase Equilibria and Diffusion》2005,26(5):472-476
For the effective use of short-lived radioactive beams, soon to be available at the Tokai Radioactive Ion Accelerator Complex, the authors have developed a radiotracer method for diffusion studies in solids. The experimental test was performed by the measurement of the diffusion coefficients of Li in a sample of the compound βLiAl using an α-emitting radiotracer of 8Li (T1/2=0.84 s). It was found that the time-dependent yields of the α particles from the diffusing 8Li that was initially implanted in the sample could be used as a measure of the diffusivity of the tracer in a nondestructive way. The method was applied to measure the self-diffusion coefficients of Li in βLiGa, and for investigating how the Li diffusion in the Li ionic conductors is affected by the concentration of atomic defects (i.e., the existence of the atomic vacancies of Li and the defects in Ga sites that are replaced by Li). 相似文献
8.
Clinicopathological significance of intratubular giant macrophages in progressive glomerulonephritis
T Oda O Hotta Y Taguma H Kitamura H Sugai S Onodera I Horigome K Suzuki Y Shouji T Furuta S Chiba N Yoshizawa H Nagura 《Canadian Metallurgical Quarterly》1998,53(5):1190-1200
Very large macrophages, which we have termed "giant macrophages" (G-M phi), have been found in renal tubules, some containing cytoplasmic vacuoles. To elucidate their pathophysiological roles, we examined renal biopsy tissues from various primary glomerulonephritis (GN) and tubulointerstitial nephritis (TIN) using immunohistochemistry with monoclonal antibodies against M phi and other cell surface markers. Giant macrophages were absent or rare in TIN, minimal change nephrotic syndrome, and minor glomerular abnormalities, but G-M phi was plentiful in progressive glomerulonephrides such as IgA nephropathy with crescents, membranoproliferative GN, focal segmental glomerulosclerosis, and especially in crescentic GN. These G-M phi were usually seen in the lumen of renal tubules, but occasionally were found in the Bowman's spaces and glomerular tufts, and similar cells were also found in urine. Moreover, they frequently made contact with tubular epithelial cells expressing intercellular adhesion molecule-1, and the tubular epithelial cells in such lesions often had degenerative changes. Giant M phi may damage tubular epithelial cells from the luminal side. Phenotypically, G-M phi showed activated (CD71+) and mature (25F9+) characteristics along with features of M phi (CD68+), and the cytoplasm contained a great deal of lipids. The numbers of G-M phi in renal tissues closely correlated with the degree of hematuria (rho = 0.5, P < 0.001), serum creatinine value (r = 0.63, P < 0.001) in GN patients (N = 96) and with proteinuria in IgA nephropathy patients (r = 0.89, P < 0.001, N = 27). These data suggest that G-M phi are M phi that were activated and matured in certain active inflammatory sites, which flowed into tubules and then into urine. Thus, the existence of G-M phi in biopsy tissue or urine reflect the activity of GN and may have a predictive value for the progression of GN. 相似文献
9.
Hitoshi Takamura Hiroshi Sugai Masato Watanabe Takehiro Kasahara Atsunori Kamegawa Masuo Okada 《Journal of Electroceramics》2006,17(2-4):741-748
The preparation and oxygen permeation properties of the (Ce0.8Pr0.2)O2−δ − x vol% MnFe2O4 composites, where x = 0 to 35, have been investigated. The samples were prepared by the Pechini method. In the case of Ce0.8Pr0.2O2−δ, an oxygen flux density of 6 μmol⋅cm−2⋅s−1 (L = 0.0247 cm) and the maximum methane conversion of 50% were attained at 1000∘C. Unlike composites consisting of Gd-doped CeO2 and MnFe2O4, the oxygen permeability of the (Ce0.8Pr0.2)O2−δ – x vol% MnFe2O4 composites was almost constant regardless of the volume fraction of MnFe2O4; however, the optimum volume fraction of MnFe2O4 was determined to be 5 to 25 in the context of the chemical and mechanical stabilities under methane conversion atmosphere.
In addition, the surface modification of the (Ce0.8Gd0.2)O2−δ – 15 vol% MnFe2O4 composite was performed by using the FePt nanoparticles. The catalyst loading of 2.8 mg/cm2 on the both side of the 0.3 mm-thick (Ce0.8Gd0.2)O2−δ – 15vol% MnFe2O4 composite increased the oxygen flux density from 0.30 to 0.76 μmol⋅cm−2⋅s−1 in the case of He/air gradients; however, the effect seems to be reduced in the case of high oxygen flux density caused by
a large pO2 gradient. Moreover, the Langmuir-Blodgett film of the FePt nanoparticles were successfully prepared on the tape-cast (Ce0.8Gd0.2)O2−δ – 15vol% MnFe2O4 composite. Hydrophobic treatments for the surface of the composite were crucial to achieve high transfer ratio for the deposition
of the LB film. 相似文献
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