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Jung Hye-Lim Yang Sung-Yong Pyo Min Cheol Hong Chung-Oui Nam Mi-Hyun Lee Jin-Won Lee Kwang-Won 《Food science and biotechnology》2019,28(2):555-562
Food Science and Biotechnology - Although chebulic acid isolated from Terminalia chebular has diverse biological effects, its effects on the expression of nuclear factor erythroid 2-related factor... 相似文献
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Yun-Chang Koo Chung-Oui Hong Mi-Hyun Nam Ji Hoon Kim Sung-Yong Yang Nam-Hee Won Tae-Sun Park Kwang-Won Lee 《Food science and biotechnology》2013,22(3):871-880
Ethyl acetate layer of methanol extract (TCE) of yellow myrobalan (Terminalia chebula) contains 2.4% of chebulic acid, a standard compound in TCE, which have a strong anti-oxidative effect and was reported in our previous study. Thirty-one male SD rats were randomly divided into 5 groups (normal control, CCl4 control, TCE control, CCl4+high dose TCE, and low dose TCE). Liver fibrosis was induced by i.p. injection of CCl4 and TCE were orally administrated. TCE decreased the up-regulated malondealdehyde value and increased the down-regulated ratio of GSH/GSSG content and activities of GRd, GPx, and GST compared to the CCl4 control group. Decreased dysfunction and inflammatory reaction in liver was confirmed by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, relative liver weight and infiltration of neutrophils. Also, TCE inhibited phenotype change of hepatic stellate cells (HSC) by reducing α-smooth muscle actin (α-SMA) gene expression and protein production. Inhibition of collagen 1A1 gene expression and protein production were also confirmed. From these results, TCE may be a useful material for preventing liver fibrosis. 相似文献
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