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排序方式: 共有260条查询结果,搜索用时 15 毫秒
1.
Magnuson James S.; Tanenhaus Michael K.; Aslin Richard N.; Dahan Delphine 《Canadian Metallurgical Quarterly》2003,132(2):202
The time course of spoken word recognition depends largely on the frequencies of a word and its competitors, or neighbors (similar-sounding words). However, variability in natural lexicons makes systematic analysis of frequency and neighbor similarity difficult. Artificial lexicons were used to achieve precise control over word frequency and phonological similarity. Eye tracking provided time course measures of lexical activation and competition (during spoken instructions to perform visually guided tasks) both during and after word learning, as a function of word frequency, neighbor type, and neighbor frequency. Apparent shifts from holistic to incremental competitor effects were observed in adults and neural network simulations, suggesting such shifts reflect general properties of learning rather than changes in the nature of lexical representations. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Delphine Patriarche Emmanuel Ledoux Rgine Simon-Coinon Jean-Luc Michelot Justo Cabrera 《Applied Clay Science》2004,26(1-4):109
Argillites are one of the geological formations studied by IRSN for their confining properties for isolation of radioactive wastes. One of the main objectives is the study of water transport through rocks with very low water content and very low hydraulic conductivity by modeling of natural tracer profiles. This paper presents the protocol developed for and applied to the acquisition of data for chloride content in interstitial water of the Toarcian argillites at the Tournemire site (Southern France). This protocol is based on laboratory diffusion experiments and on modeling. Experimental data obtained during the transient and steady-state parts of diffusion experiments enable, respectively, the assessment of the diffusion coefficient and the determination of Cl concentration in pore water. Using this protocol, profiles with depth for both of these data sets have been acquired along the geological sequence. Taking into account the present knowledge of the geological and hydrogeological history of the Tournemire massif, a conceptual model granting the main role for mass transport to diffusion has been proposed. According to this conceptual model, a one-dimensional numerical model was built for simulating the mass transport of chloride through the sedimentary column, over 53 Ma. The good agreement between experimental data and calculated values for both diffusion coefficients and concentrations of chloride confirms that diffusion is likely the main process for mass transport in the massif. This model was also tested with the deuterium content of interstitial water, applying variable concentrations at the aquifer system boundaries for reflecting the thermal dependency of isotopic composition in precipitation. These simulations also reveal the likely important role of heterogeneities, such as fractures, in the variability of tracer concentrations with regards to a simple diffusion profile. 相似文献
3.
Pflieger D Gonnet F de la Fuente van Bentem S Hirt H de la Fuente A 《Mass spectrometry reviews》2011,30(2):268-297
Proteomes are intricate. Typically, thousands of proteins interact through physical association and post-translational modifications (PTMs) to give rise to the emergent functions of cells. Understanding these functions requires one to study proteomes as "systems" rather than collections of individual protein molecules. The abstraction of the interacting proteome to "protein networks" has recently gained much attention, as networks are effective representations, that lose specific molecular details, but provide the ability to see the proteome as a whole. Mostly two aspects of the proteome have been represented by network models: proteome-wide physical protein-protein-binding interactions organized into Protein Interaction Networks (PINs), and proteome-wide PTM relations organized into Protein Signaling Networks (PSNs). Mass spectrometry (MS) techniques have been shown to be essential to reveal both of these aspects on a proteome-wide scale. Techniques such as affinity purification followed by MS have been used to elucidate protein-protein interactions, and MS-based quantitative phosphoproteomics is critical to understand the structure and dynamics of signaling through the proteome. We here review the current state-of-the-art MS-based analytical pipelines for the purpose to characterize proteome-scale networks. 相似文献
4.
Ren Ferrera Marie Vdre Megane Lo-Grasso Lionel Augeul Christophe Chouabe Gabriel Bidaux Delphine Baetz 《International journal of molecular sciences》2022,23(21)
Heart transplantation is facing a shortage of grafts. Donation after Circulatory Death (DCD) would constitute a new potential of available organs. In the present work, we aimed to evaluate whether Postconditioning (ischemic or with ciclosporin-A (CsA)) could reduce ischemia-reperfusion injury in a cardiac arrest model when applied at the start of reperfusion or after a delay. An isolated rat heart model was used as a model of DCD. Hearts were submitted to a cardiac arrest of 40 min of global warm ischemia (37 °C) followed by 3 h of 4 °C-cold preservation, then 60 min reperfusion. Hearts were randomly allocated into the following groups: control, ischemic postconditioning (POST, consisting of two episodes each of 30 s ischemia and 30 s reperfusion at the onset of reperfusion), and CsA group (CsA was perfused at 250 nM for 10 min at reperfusion). In respective subgroups, POST and CsA were applied after a delay of 3, 10, and 20 min. Necrosis was lower in CsA and POST versus controls (p < 0.01) whereas heart functions were improved (p < 0.01). However, while the POST lost its efficacy if delayed beyond 3 min of reperfusion, CsA treatment surprisingly showed a reduction of necrosis even if applied after a delay of 3 and 10 min of reperfusion (p < 0.01). This cardioprotection by delayed CsA application correlated with better functional recovery and higher mitochondrial respiratory index. Furthermore, calcium overload necessary to induce mitochondrial permeability transition pore (MPTP) opening was similar in all cardioprotection groups, suggesting a crucial role of MPTP in this delayed protection of DCD hearts. 相似文献
5.
Pierre-Emmanuel Baurand Jrmy Balland Chlo Reynas Mlanie Ramseyer Delphine Vivier Pierre-Simon Bellaye Bertrand Collin Catherine Paul Franck Denat Kamal Asgarov Jean-Ren Pallandre Laurence Ringenbach 《International journal of molecular sciences》2022,23(20)
The human leucine-rich repeat-containing protein 15 (LRRC15) is a membrane protein identified as a marker of CAF (cancer-associated fibroblast) cells whose overexpression is positively correlated with cancer grade and outcome. Nuclear molecular imaging (i.e., SPECT and PET) to track LRRC15 expression could be very useful in guiding further therapeutic strategies. In this study, we developed an ScFv mouse phage-display library to obtain small fragment antibodies against human LRRC15 for molecular imaging purposes. Mice were immunized with recombinant human LRRC15 (hLRRC15), and lymph node cells were harvested for ScFv (single-chain variable fragment) phage-display analysis. The built library was used for panning on cell lines with constitutive or induced expression after transfection. The choice of best candidates was performed by screening various other cell lines, using flow cytometry. The selected candidates were reformatted into Cys-ScFv or Cys-diabody by addition of cysteine, and cloned in mammalian expression vectors to obtain batches of small fragments that were further used in site-specific radiolabeling tests. The obtained library was 1.2 × 107 cfu/µg with an insertion rate >95%. The two panning rounds performed on cells permittedenrichment of 2 × 10−3. Screening with flow cytometry allowed us to identify 28 specific hLRRC15 candidates. Among these, two also recognized murine LRCC15 and were reformatted into Cys-ScFv and Cys-diabody. They were expressed transiently in a mammalian system to obtain 1.0 to 4.5 mg of Cys fragments ready for bioconjugation and radiolabeling. Thus, in this paper, we demonstrate the relevance of the phage-display ScFv library approach for the fast-track development of small antibodies for imaging and/or immunotherapy purposes. 相似文献
6.
Pieter Geiregat Carmelita Rodá Ivo Tanghe Shalini Singh Alessio Di Giacomo Delphine Lebrun Gianluca Grimaldi Jorick Maes Dries Van Thourhout Iwan Moreels Arjan J.Houtepen Zeger Hens 《光:科学与应用(英文版)》2021,10(6):1122-1132
2D materials are considered for applications that require strong light-matter interaction because of the apparently giant oscillator strength of the exciton tra... 相似文献
7.
Clémence Demangel Delphine Auzène Muriel Vayssade Jean-Luc Duval Pascale Vigneron Marie-Danièle Nagel Jean-Claude Puippe 《Materials science & engineering. C, Materials for biological applications》2012,32(7):1919-1925
Metal injection molding (MIM) is a near net shape manufacturing method that allows for the production of components of small to moderate size and complex shape. MIM is a cost-effective and flexible manufacturing technique that provides a large innovative potential over existing methods for the industry of implantable devices. Commercially pure titanium (CP-Ti) samples were machined to the same shape as a composite feedstock with titanium and polyoxymethylene, and these metals were injected, debinded and sintered to assess comparative biological properties. Moreover, we treated MIM-Ti parts with BIOCOAT®, BIODIZE® and BIOCER®, three different anodic oxidation techniques that treat titanium using acid, alkaline and anion enriched electrolytes, respectively. Cytocompatibility as well as morphological and chemical features of surfaces was comparatively assessed on each sample, and the results revealed that MIM-Ti compared to CP-Ti demonstrated a specific surface topography with a higher roughness. MIM-Ti and BIOCER® samples significantly enhanced cell proliferation, cell adhesion and cell differentiation compared to CP-Ti. Interestingly, in the anodization post-treatment established in this study, we demonstrated the ability to improve osseointegration through anionic modification treatment. The excellent biological response we observed with MIM parts using the injection molding process represents a promising manufacturing method for the future implantable devices in direct contact with bones. 相似文献
8.
In a recent paper we presented the first adaptive control design for an ODE system with a possibly large actuator delay of unknown length. We achieved global stability under full state feedback. In this paper we generalize the design to the situation where, besides the unknown delay value, the ODE also has unknown parameters, and where trajectory tracking (rather than equilibrium regulation) is pursued. 相似文献
9.
Combined continuum damage‐embedded discontinuity model for explicit dynamic fracture analyses of quasi‐brittle materials 下载免费PDF全文
Timo Saksala Delphine Brancherie Isaac Harari Adnan Ibrahimbegovic 《International journal for numerical methods in engineering》2015,101(3):230-250
In this paper, a novel constitutive model combining continuum damage with embedded discontinuity is developed for explicit dynamic analyses of quasi‐brittle failure phenomena. The model is capable of describing the rate‐dependent behavior in dynamics and the three phases in failure of quasi‐brittle materials. The first phase is always linear elastic, followed by the second phase corresponding to fracture‐process zone creation, represented with rate‐dependent continuum damage with isotropic hardening formulated by utilizing consistency approach. The third and final phase, involving nonlinear softening, is formulated by using an embedded displacement discontinuity model with constant displacement jumps both in normal and tangential directions. The proposed model is capable of describing the rate‐dependent ductile to brittle transition typical of cohesive materials (e.g., rocks and ice). The model is implemented in the finite element setting by using the CST elements. The displacement jump vector is solved for implicitly at the local (finite element) level along with a viscoplastic return mapping algorithm, whereas the global equations of motion are solved with explicit time‐stepping scheme. The model performance is illustrated by several numerical simulations, including both material point and structural tests. The final validation example concerns the dynamic Brazilian disc test on rock material under plane stress assumption. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
10.
Delphine Vincent AnhDuyen Bui Doris Ram Vilnis Ezernieks Frank Bedon Joe Panozzo Pankaj Maharjan Simone Rochfort Hans Daetwyler Matthew Hayden 《International journal of molecular sciences》2022,23(2)
Bread wheat is the most widely cultivated crop worldwide, used in the production of food products and a feed source for animals. Selection tools that can be applied early in the breeding cycle are needed to accelerate genetic gain for increased wheat production while maintaining or improving grain quality if demand from human population growth is to be fulfilled. Proteomics screening assays of wheat flour can assist breeders to select the best performing breeding lines and discard the worst lines. In this study, we optimised a robust LC–MS shotgun quantitative proteomics method to screen thousands of wheat genotypes. Using 6 cultivars and 4 replicates, we tested 3 resuspension ratios (50, 25, and 17 µL/mg), 2 extraction buffers (with urea or guanidine-hydrochloride), 3 sets of proteases (chymotrypsin, Glu-C, and trypsin/Lys-C), and multiple LC settings. Protein identifications by LC–MS/MS were used to select the best parameters. A total 8738 wheat proteins were identified. The best method was validated on an independent set of 96 cultivars and peptides quantities were normalised using sample weights, an internal standard, and quality controls. Data mining tools found particularly useful to explore the flour proteome are presented (UniProt Retrieve/ID mapping tool, KEGG, AgriGO, REVIGO, and Pathway Tools). 相似文献