Exceptionally high seizure threshold: ECT device limitations

Numerous studies have confirmed the distinct biological behavior of two subsets of prostate cancer diagnosed incidentally after either transurethral resection (TURP) or open prostatectomy for presumed benign prostatic hyperplasia (BPH). Focal, low-grade lesions are associated with a low risk for clinical progression and are designated as stage T1a or A1. These cases have traditionally been managed conservatively with close clinical observation. In contrast, multifocal, high-volume, or high-grade tumors are associated with a more aggressive clinical course and are designated as stage T1b or A2. Early definitive intervention is usually advocated for these latter patients. Therefore, accurate pathological assignment to either stage T1a or T1b is crucial for selection of appropriate management options. A variety of methods for staging patients with incidentally detected prostate cancer have been proposed, including detailed histological analysis, repeat TURP or transurethral biopsy, serial prostate-specific antigen (PSA) analysis, and imaging with either transrectal ultrasound (TRUS) or magnetic resonance (MRI) techniques. This article critically examines the clinical utility of these staging modalities for patients with incidentally detected prostate cancer.     

Developing a Dynamic Cluster Quantization based Lossless Audio Compression (DCQLAC)

In this paper, an approach has been made to produce a compressed audio without losing any information. The proposed scheme is fabricated with the help of dynamic cluster quantization followed by Burrows Wheeler Transform (BWT) and Huffman coding. The encoding algorithm has been designed in two phases, i.e., dynamic cluster selection (of sampled audio) followed by dynamic bit selection for determining quantization level of individual cluster. Quantization level of each cluster is selected dynamically based on mean square quantization error (MSQE). Bit stream is further compressed by applying Burrows Wheeler Transform (BWT) and Huffman code respectively. Experimental results are supported with current state-of-the-art in audio quality analysis (like statistical parameters (compression ratio, space savings, SNR, PSNR) along with other parameters (encoding time, decoding time, Mean Opinion Score (MOS) and entropy) and compared with other existing techniques.

     

Preprogramming Floating Time of Liquid Marble

Non-sticking droplets wrapped with fine hydrophobic particles, namely liquid marbles, can be transported both on solid and water pool without an undesired spill of the inner encapsulated liquid. While the stimuli-responsive release of the inner liquid in the target area is proposed, the time-programmed release is not yet achieved. Herein, the hydrophobicity of nanoclay is modulated via a catalyst-free 1,4-conjugate addition reaction to form liquid marbles. This nanoclay liquid marble is robust and stable in air but collapses on the liquid pool with a specific lifetime. The lifetime of the liquid marble can be modulated over seconds to hours scale depending on the selection of chemically modulated wettability of the nanoclay. The critical mechanism of lifetime modulation is responsible for controlling the coalescence kinetics between the water pool and inner liquid by nanoclays’ high diffusion length and chemically varied water spreading potential. The NC liquid marble's programmable lifetime to ‘time-bomb’ type drug release and cascade chemical reaction is applied—without requiring any external intervention.     

Modulatory Effects of Biosynthesized Gold Nanoparticles Conjugated with Curcumin and Paclitaxel on Tumorigenesis and Metastatic Pathways—In Vitro and In Vivo Studies

Background: Breast cancer is the most common cancer in women globally, and diagnosing it early and finding potential drug candidates against multi-drug resistant metastatic breast cancers provide the possibilities of better treatment and extending life. Methods: The current study aimed to evaluate the synergistic anti-metastatic activity of Curcumin (Cur) and Paclitaxel (Pacli) individually, the combination of Curcumin–Paclitaxel (CP), and also in conjugation with gold nanoparticles (AuNP–Curcumin (Au-C), AuNP–Paclitaxel (Au-P), and AuNP–Curcumin–Paclitaxel (Au-CP)) in various in vitro and in vivo models. Results: The results from combination treatments of CP and Au-CP demonstrated excellent synergistic cytotoxic effects in triple-negative breast cancer cell lines (MDA MB 231 and 4T1) in in vitro and in vivo mouse models. Detailed mechanistic studies were performed that reveal that the anti-cancer effects were associated with the downregulation of the expression of VEGF, CYCLIN-D1, and STAT-3 genes and upregulation of the apoptotic Caspase-9 gene. The group of mice that received CP combination therapy (with and without gold nanoparticles) showed a significant reduction in the size of tumor when compared to the Pacli alone treatment and control groups. Conclusions: Together, the results suggest that the delivery of gold conjugated Au-CP formulations may help in modulating the outcomes of chemotherapy. The present study is well supported with observations from cell-based assays, molecular and histopathological analyses.     

Triplex Formation by Oligonucleotides Containing Organomercurated Base Moieties

Homothymine oligonucleotides with a single 5‐mercuricytosine or 5‐mercuriuracil residue at their termini have been synthesized and their capacity to form triplexes has been examined with an extensive array of double‐helical targets. UV and circular dichroism (CD) melting experiments revealed the formation and thermal denaturation of pyrimidine ? purine*pyrimidine‐type triple helices with all oligonucleotide combinations studied. Nearly all triplexes were destabilized upon mercuration of the 3′‐terminal residue of the triplex‐forming oligonucleotide, in all likelihood due to competing intramolecular Hg^II‐mediated base pairing. Two exceptions from this general pattern were, however, observed: 5‐mercuricytosine was stabilizing when placed opposite to a T ? A or A ? T base pair. The stabilization was further amplified in the presence of 2‐mercaptoethanol (but not hexanethiol, thiophenol or cysteine), suggesting a stabilizing interaction other than Hg^II‐mediated base pairing.     

An alternative one sided test of normal mean

This paper provides an alternative test procedure for the problem oftesting of normal mean for one sided alternative when the variance is known in case of costly trials. The proposed test is based on a sampling scheme which we call 'continuous adaptive design'. Some exact andasymptotic results related to the test and design are studied.     

Fabrication of portable solar thermal bank for indoor cooking

The aim of this report is to build a portable solar thermal bank based on a Scheffler reflector that is capable of boiling-type cooking using HITEC as a thermal storage material. This report reviews the problems related to solar cooking and evaluates the novel layout of a portable solar thermal bank which includes a daily thermal storage vessel. This stove is in the shape of a cylindrical container filled with phase-changing latent heat storage material. Inside the container, we provide a small gap taking into account the volumetric expansion of the phase change material (PCM) during the melting process. The solar thermal bank is charged in the sun. It is placed directly for a few hours under the focus of a Scheffler reflector, which charges the solar thermal bank with enough thermal energy stored. After a while, the cooking process can be completed by users using that stored heat. The top cavity is used as a cooking pot in a solar thermal bank. Cooking meals do not require direct sunlight, which is typical for most solar cookers. The portable solar thermal bank is an alternative for low-income households and adapts to local traditions of indoor cooking. It is portable and can be used safely to cook indoors or outdoors. In this study, a solar cooker with a thermal storage device was developed using a PCM. The size of the stove has been calculated by calculating the energy consumption for two to three people. HITEC salt has been chosen as a phase change material for thermal storage, which will be used for cooking when there is no sunlight. It enhances the applicability of solar cooking and preserves cooking possibilities using energy stored throughout the day at low production costs.     

Sequential comparison of two treatments in clinical trials:a decision theoretic approach based on randomized play-the-winner rule

In the context of comparing two treatments in clinical trials randomized play-the-winner rule is used with the goal of treating more patients by the better treatment On its basis we give two decision rules by introducing stopping rule Some performance characteristics of one of the decision rules are discussed and examined .A minimax rule is suggested Finally some exact and asymptotic properties of the decision rule is derived