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1.
Arunas Augustinaitis Richard Ennals Egle Malinauskiene Rimantas Petrauskas 《AI & Society》2009,23(1):41-50
The paper reflects on the unique experience of social and technological development in Lithuania since the regaining of independence
as a newly reshaped society constructing a distinctive competitive IST-based model at global level. This has presented Lithuanian
pattern of how to integrate different experiences and relations between generations in implementing complex information society
approaches. The resulting programme in general is linked to the Lisbon objectives of the European Union. The experience of
transitional countries in Europe, each different but facing some common problems, may be useful to developing countries in
Africa.
相似文献
Arunas Augustinaitis (Corresponding author)Email: |
Richard EnnalsEmail: |
Egle MalinauskieneEmail: |
Rimantas PetrauskasEmail: |
2.
Greta Jarockyte Egle Daugelaite Marius Stasys Urte Statkute Vilius Poderys Ting-Chen Tseng Shan-Hui Hsu Vitalijus Karabanovas Ricardas Rotomskis 《International journal of molecular sciences》2016,17(8)
The uptake and distribution of negatively charged superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs) in mouse embryonic fibroblasts NIH3T3, and magnetic resonance imaging (MRI) signal influenced by SPIONs injected into experimental animals, were visualized and investigated. Cellular uptake and distribution of the SPIONs in NIH3T3 after staining with Prussian Blue were investigated by a bright-field microscope equipped with digital color camera. SPIONs were localized in vesicles, mostly placed near the nucleus. Toxicity of SPION nanoparticles tested with cell viability assay (XTT) was estimated. The viability of NIH3T3 cells remains approximately 95% within 3–24 h of incubation, and only a slight decrease of viability was observed after 48 h of incubation. MRI studies on Wistar rats using a clinical 1.5 T MRI scanner were showing that SPIONs give a negative contrast in the MRI. The dynamic MRI measurements of the SPION clearance from the injection site shows that SPIONs slowly disappear from injection sites and only a low concentration of nanoparticles was completely eliminated within three weeks. No functionalized SPIONs accumulate in cells by endocytic mechanism, none accumulate in the nucleus, and none are toxic at a desirable concentration. Therefore, they could be used as a dual imaging agent: as contrast agents for MRI and for traditional optical biopsy by using Prussian Blue staining. 相似文献
3.
Dominik Kiem Michael Leisch Daniel Neureiter Theresa Haslauer Alexander Egle Thomas Melchardt Max S. Topp Richard Greil 《International journal of molecular sciences》2021,22(11)
Background: Chimeric antigen receptor (CAR) T-cells are changing the therapeutic landscape of hematologic malignancies. Severe side effects include cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), but prolonged cytopenia has also been reported. The underlying mechanism for prolonged cytopenia is poorly understood so far. Cases: Severe pancytopenia with grade 2-3 anemia was marked 2–3 months after treatment. Laboratory evaluation revealed undetectable levels of haptoglobin with increased reticulocyte counts. Coomb’s tests were negative, no schistocytes were detected on blood smear, and infectious causes were ruled out. Increased erythropoiesis without lymphoma infiltration was noted on bone marrow biopsy. A spontaneous increase in haptoglobin and hemoglobin levels was observed after several weeks. For one patient, peripheral CAR-T levels were monitored over time. We observed a decline at the same time as hemoglobin levels began to rise, implying a potential causality. Conclusion: To our knowledge, we describe the first two cases of Coombs-negative hemolytic anemia after CAR-T treatment for B-cell lymphoma. We encourage routine monitoring for hemolytic anemia after CAR-T treatment and also encourage further investigations on the underlying mechanism. 相似文献
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6.
Markus Steiner Franz J. Gassner Thomas Parigger Daniel Neureiter Alexander Egle Roland Geisberger Richard Greil Nadja Zaborsky 《International journal of molecular sciences》2021,22(17)
Chronic lymphocytic leukemia (CLL) is considered a clonal B cell malignancy. Sporadically, CLL cases with multiple productive heavy and light-chain rearrangements were detected, thus leading to a bi- or oligoclonal CLL disease with leukemic cells originating either from different B cells or otherwise descending from secondary immunoglobulin rearrangement events. This suggests a potential role of clonal hematopoiesis or germline predisposition in these cases. During the screening of 75 CLL cases for kappa and lambda light-chain rearrangements, we could detect a single case with CLL cells expressing two distinct kappa and lambda light chains paired with two separate immunoglobulin heavy-chain variable regions. Furthermore, this patient also developed a prostate carcinoma. Targeted genome sequencing of highly purified light-chain specific CLL clones from this patient and from the prostate carcinoma revealed the presence of a rare germline polymorphism in the POLE gene. Hence, our data suggest that the detected SNP may predispose for cancer, particularly for CLL. 相似文献
7.
Stefan Megel Egle GirdauskaiteViktar Sauchuk Mihails KusnezoffAlexander Michaelis 《Journal of power sources》2011,196(17):7136-7143
Planar solid oxide fuel cells (SOFC) are considered to be power generators with high efficiency and low emission at small power units (1-200 kWel). Many prototype systems are already successfully realized. For mass production the costs have to be reduced and the long-term stability has to be enhanced. Power losses <0.5%/1000 h is the target value for stacks in stationary SOFC-based power systems. To reach this goal, the factors influencing degradation have to be found and reduced. In this work the interaction between interconnect and different ceramic materials such as perovskites (La0.8Sr0.2(Mn,Co)O3, La0.65Sr0.3MnO3, La0.65Sr0.3(Mn,Co)O3) and spinels (Mn(Co,Fe)O4, (Cu,Ni)Mn2O4) was investigated on the cathode (air) side of conventional ferritic interconnect materials (CroFer22APU, ITMLC, ZMG232L). The method to determine the value of the area specific resistance between interconnect and contact layer (R#ICC) within a tolerance of 10% has been developed to provide reliable data for ASR values and their degradation.The R#ICC-value increases with annealing time. The degree of this increase depends on used materials and their combination. The spinel contact layers form a thin dense ceramic layer at the beginning of the annealing process. This layer reduces the oxidation rate of the alloy. Because of this protection layer a thinner oxide scale grows and the ASR aging rate is much lower (0.4-0.9 mΩ cm2/1000 h). The comparison of the aging rates of different alloys with La0.8Sr0.2(Mn,Co)O3 contact layer reveals remarkable differences: 3.1 mΩ cm2/1000 h for CroFer22APU, 10.9 mΩ cm2/1000 h for ITMLC and 21.2 mΩ cm2/1000 h for ZMG232L.The degradation in a stack has been determined from the R#ICC-values and geometric factors. The impact of oxidation at the cathode side of interconnect is about one third of the total stack degradation. The method opens the possibility for comparing area specific resistances of special material combinations with high accuracy. By optimized material combinations the degradation in stacks can be reduced to <0.5%/1000 h. 相似文献
8.
Virgili T Grancini G Molotokaite E Suarez-Lopez I Rajendran SK Liscio A Palermo V Lanzani G Polli D Cerullo G 《Nanoscale》2012,4(7):2219-2226
This article is devoted to the exploration of the benefits of a new ultrafast confocal pump-probe technique, able to study the photophysics of different structured materials with nanoscale resolution. This tool offers many advantages over standard stationary microscopy techniques because it directly interrogates excited state dynamics in molecules, providing access to both radiative and non-radiative deactivation processes at a local scale. In this paper we present a few different examples of its application to organic semiconductor systems. The first two are focussed on the study of the photophysics of phase-separated polymer blends: (i) a blue-emitting polyfluorene (PFO) in an inert matrix of PMMA and (ii) an electron donor polythiophene (P3HT) mixed with an electron acceptor fullerene derivative (PCBM). The experimental results on these samples demonstrate the capability of the technique to unveil peculiar interfacial dynamics at the border region between phase-segregated domains, which would be otherwise averaged out using conventional pump-probe spectroscopy. The third example is the study of the photophysics of isolated mesoscopic crystals of the PCBM molecule. Our ultrafast microscope could evidence the presence of two distinctive regions within the crystals. In particular, we could pinpoint for the first time areas within the crystals showing photobleaching/stimulated emission signals from a charge-transfer state. 相似文献
9.
Elena Jimnez-Ortega Egle Narmontaite Beatriz Gonzlez-Prez Francisco J. Plou María Fernndez-Lobato Julia Sanz-Aparicio 《International journal of molecular sciences》2022,23(23)
Rhodotorula dairenensis β-fructofuranosidase is a highly glycosylated enzyme with broad substrate specificity that catalyzes the synthesis of 6-kestose and a mixture of the three series of fructooligosaccharides (FOS), fructosylating a variety of carbohydrates and other molecules as alditols. We report here its three-dimensional structure, showing the expected bimodular arrangement and also a unique long elongation at its N-terminus containing extensive O-glycosylation sites that form a peculiar arrangement with a protruding loop within the dimer. This region is not required for activity but could provide a molecular tool to target the dimeric protein to its receptor cellular compartment in the yeast. A truncated inactivated form was used to obtain complexes with fructose, sucrose and raffinose, and a Bis-Tris molecule was trapped, mimicking a putative acceptor substrate. The crystal structure of the complexes reveals the major traits of the active site, with Asn387 controlling the substrate binding mode. Relevant residues were selected for mutagenesis, the variants being biochemically characterized through their hydrolytic and transfructosylating activity. All changes decrease the hydrolytic efficiency against sucrose, proving their key role in the activity. Moreover, some of the generated variants exhibit redesigned transfructosylating specificity, which may be used for biotechnological purposes to produce novel fructosyl-derivatives. 相似文献
10.
Egle Sendzikiene Violeta Makareviciene Prutenis Janulis Dovile Makareviciute 《European Journal of Lipid Science and Technology》2007,109(5):493-497
One of the positive features of biofuel concerning environmental protection is its high biodegradability. Fuel is considered to be biodegradable if not less than 90% of it degrades within 21 days. The aim of this work was to determine the biodegradability of various kinds of fatty acid methyl esters and their mixtures with fossil diesel fuel in natural environments. It was determined that fatty acid methyl esters meet the requirements for biodegradability set by the EU. Of rapeseed oil fatty acid methyl esters (RME), 91.2% degraded within 21 days, compared to 94.2% of rapeseed oil fatty acid ethyl esters, 98.3% of linseed oil fatty acid methyl esters (LSME), 90% of tallow fatty acid methyl esters, and 92.5% of pork lard fatty acid methyl esters (LME), while the amount of degraded fossil diesel fuel reached only 57.3%. The biodegradability of multi‐component biofuels containing RME, LSME and LME is similar; the best is of a mixture of 70% RME, 6% LSME and 24% LME. It was determined that more than 90% of multi‐component biofuel and fossil diesel fuel mixtures degrade within 21 days when they contain 35% and more of multi‐component biofuel. 相似文献