One-dimensional GIS-based model compared with a two-dimensional model in urban floods simulation.

A GIS-based one-dimensional flood simulation model is presented and applied to the centre of the city of N?mes (Gard, France), for mapping flow depths or velocities in the streets network. The geometry of the one-dimensional elements is derived from the Digital Elevation Model (DEM). The flow is routed from one element to the next using the kinematic wave approximation. At the crossroads, the flows in the downstream branches are computed using a conceptual scheme. This scheme was previously designed to fit Y-shaped pipes junctions, and has been modified here to fit X-shaped crossroads. The results were compared with the results of a two-dimensional hydrodynamic model based on the full shallow water equations. The comparison shows that good agreements can be found in the steepest streets of the study zone, but differences may be important in the other streets. Some reasons that can explain the differences between the two models are given and some research possibilities are proposed.     

Using an integrated process of data and modeling in HRA

The paper describes an approach taken to estimate the probabilities of failure associated with various railroad tasks to prevent accidents (principally collisions and derailments). These probabilities were estimated using an expert elicitation process that used partially relevant data available from a variety of databases and that were filtered and scaled to make them more directly relevant to the analyses being performed. Extensive qualitative studies were performed prior to the elicitation process to identify relevant contexts under which the tasks can be performed.     

Statistical prediction of fracture parameters of concrete and implications for choice of testing standard

This article shows how the fracture energy of concrete, as well as other fracture parameters such as the effective length of the fracture process zone, critical crack-tip opening displacement and the fracture toughness, can be approximately predicted from the standard compression strength, maximum aggregate size, water-cement ratio, and aggregate type (river or crushed). A database, consisting of 238 test data, is extracted from the literature and tabulated, and approximate mean prediction formulae calibrated by this very large data set are developed. A distinction is made between (a) the fracture energy, G_f, corresponding to the area under the initial tangent of the softening stress-separation curve of cohesive crack model, which governs the maximum loads of structures and is obtained by the size effect method (SEM) or related methods (Jenq-Shah two-parameter method and Karihaloo's effective crack model, ECM) and (b) the fracture energy, G_F, corresponding to the area under the complete stress-separation curve, which governs large postpeak deflections of structures and is obtained by the work-of-fracture method (WFM) proposed for concrete by Hillerborg. The coefficients of variation of the errors in the prediction formulae compared to the test data are calculated; they are 17.8% for G_f and 29.9% for G_F, the latter being 1.67 times higher than the former. Although the errors of the prediction formulae taking into account the differences among different concretes doubtless contribute significantly to the high values of these coefficients of variation, there is no reason for a bias of the statistics in favor of G_f or G_F. Thus, the statistics indicate that the fracture energy based on the measurements in the maximum load region is much less uncertain than that based on the measurement of the tail of the postpeak load-deflection curve. While both G_f and G_F are needed for accurate structural analysis, it follows that if the testing standard should measure, for the sake of simplicity, only one of these two fracture energies, then G_f is preferable.     

Determination of Active Slip/Twinning Modes in AZ31 Mg Alloy Near Room Temperature

In order to determine the deformation modes in AZ31 magnesium alloy at room temperature, computer simulations of deformation texture development and calculation of formability have been carried out. The simulation results were compared with the measured texture results. Based on agreement between the experiments and simulations the active deformation modes were determined. A Visco Plastic Self Consistent model was employed for the simulation of plastic deformation. Simulations and experiments were performed for different initial textures. The goal of the study was to develop the understanding of deformation texture evolution and its effects on mechanical properties of magnesium, with an ultimate goal of improving room temperature formability of magnesium alloys. This article was presented at Materials Science & Technology 2006, Innovations in Metal Forming symposium held in Cincinnati, OH, October 15-19, 2006.     

Photocatalytic degradation of a phenylurea, chlortoluron, in water using an industrial titanium dioxide coated media

The degradation of an herbicide, chlortoluron, by UV/TiO₂ photocatalysis in water using industrial titanium dioxide coated non-woven paper was studied. The influence of parameters such as adsorption capacity, initial concentration and TiO₂ implementation (coated or in suspension) was investigated. The results emphasize the importance of operational conditions and reactor geometry on the kinetic degradation rate. The analysis of the first organic by-products suggests that a hydroxyl radical attack occurs on the phenyl ring and methyl groups of the chlortoluron before the opening of the aromatic ring. The fate of hetero-atoms has been investigated. The fates of the two nitrogen atoms in the molecule are different, not only did it depend on their initial oxidation degree, as both had the same oxidation degree, but also on the initial oxidation state of neighboring carbons. The chlorine atoms were completely released as chloride ions. The study of the influence of the oxygen concentration showed the importance of the oxygen mass transfer when designing an industrial photocatalytic reactor. An original calculation process was carried out to evaluate the adsorption constant of oxygen over the whole photocatalysis period and not only in the initial conditions as previously provided. This work points out the necessity of extending the understanding of the efficiency of chlortoluron removal or of the removal of various complex pesticide mixtures found in agricultural wastewater, using alternative, more industrially realistic, reactors.     

Development of the Analysis of Fecal Stanols in the Oyster Crassostrea gigas and Identification of Fecal Contamination in Shellfish Harvesting Areas

The objective of this work was to study the effects of washing and purification steps on qualitative and quantitative analysis of fecal stanols in the oyster Crassostrea gigas using either single or a combination of lipid purification steps on silica gel or aminopropyl bonded silica gel (NH₂) or a washing step. Among the three analytical pathways compared, the two including water extraction or NH₂ purification did not lead to higher recoveries and decreased repeatabilities of extractions compared to the single purification on silica gel. This latter led to similar recoveries (ca. 80 %) and repeatabilities (ca. 10 %) for both spiked standards (coprostanol and sitostanol). This analytical pathway has been applied to oysters collected in a harvesting area in Brittany (France) where fecal contaminations are important and allowed to quantify eight stanols in oysters. The relative proportions of fecal stanols of these oysters were combined with principal component analysis in order to investigate the usefulness of their stanol fingerprints to record a fecal contamination and to distinguish its source between human, porcine and bovine contaminations. Oysters non-fecally contaminated by Escherichia coli did not present specific stanol fingerprints while oysters fecally contaminated had a bovine fingerprint, suggesting a contamination of these samples by bovine sources. As a consequence, the method developed here allows the use of stanol fingerprints of oysters as a microbial source tracking tool that can be applied to shellfish harvesting areas subjected to fecal contaminations in order to identify the different sources of contamination and improve watershed management.     

Gastric Cancer: Advances in Carcinogenesis Research and New Therapeutic Strategies

Gastric cancer’s bad incidence, prognosis, cellular and molecular heterogeneity amongst others make this disease a major health issue worldwide. Understanding this affliction is a priority for proper patients’ management and for the development of efficient therapeutical strategies. This review gives an overview of major scientific advances, made during the past 5-years, to improve the comprehension of gastric adenocarcinoma. A focus was made on the different actors of gastric carcinogenesis, including, Helicobacter pylori cancer stem cells, tumour microenvironment and microbiota. New and recent potential biomarkers were assessed as well as emerging therapeutical strategies involving cancer stem cells targeting as well as immunotherapy. Finally, recent experimental models to study this highly complex disease were discussed, highlighting the importance of gastric cancer understanding in the hard-fought struggle against cancer relapse, metastasis and bad prognosis.     

Power MOSFET quality and robustness enhancement with a new QBD characterization performed at probe–die–wafer level

The quality of the gate oxide is a central parameter for power MOSFET devices dedicated to automotive applications. Reliability is systematically evaluated through electrical tests. The purpose of this study is to apply the Q_BD test directly at probe–die–wafer level and to correlate its results with reliability test conclusions. In other words, this new kind of Q_BD test is a monitor of power MOSFET robustness which helps identify extrinsic failures and the process steps responsible. In summary, it is an accurate and fast measurement method of identifying weakened parts and enhancing device quality.