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排序方式: 共有655条查询结果,搜索用时 31 毫秒
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Ugur Gezer Ebru E. Y?rüker Metin Keskin Cemil Burak Kulle Yoganiranjana Dharuman Stefan Holdenrieder 《International journal of molecular sciences》2015,16(12):29654-29662
Circulating nucleic acids (CNAs) are under investigation as a liquid biopsy in cancer as potential non-invasive biomarkers, as stable structure in circulation nucleosomes could be valuable sources for detection of cancer-specific alterations in histone modifications. Our interest is in histone methylation marks with a focus on colorectal cancer, one of the leading cancers respective the incidence and mortality. Our previous work included the analysis of trimethylations of lysine 9 on histone 3 (H3K9me3) and of lysine 20 on histone 4 (H4K20me3) by chromatin immuno- precipitation-related PCR in circulating nucleosomes. Here we asked whether global immunologic measurement of histone marks in circulation could be a suitable approach to show their potential as biomarkers. In addition to H3K9me3 and H4K20me3 we also measured H3K27me3 in plasma samples from CRC patients (n = 63) and cancer free individuals (n = 40) by ELISA-based methylation assays. Our results show that of three marks, the amounts of H3K27me3 (p = 0.04) and H4K20me3 (p < 0.001) were significantly lower in CRC patients than in healthy controls. For H3K9me3 similar amounts were measured in both groups. Areas under the curve (AUC) in receiver operating characteristic (ROC) curves indicating the power of CRC detection were 0.620 for H3K27me3, 0.715 for H4K20me3 and 0.769 for the combination of both markers. In conclusion, findings of this preliminary study reveal the potential of blood-based detection of CRC by quantification of histone methylation marks and the additive effect of the marker combination. 相似文献
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Qingbin Cui Mehmet Emre Bayraktar Makarand Hastak Issam Minkarah 《Canadian Metallurgical Quarterly》2004,20(3):118-125
Since the introduction of warranty provisions in federal highway jobs, more and more state departments of transportation (DOTs) have considered the use of such provisions to protect their initial investment. This paper describes the pros and cons of warranty contracting in highway construction based on a survey of warranty practices in the United States. In particular, the need for state DOTs to buy a warranty for a well-built project is questioned. As an alternative, this paper introduces the warranty option, which gives the DOT the right to buy a warranty only if it becomes necessary at the end of construction. This option is exercised if the performance on site warrants it. This paper describes the mechanics of the warranty option and its advantages over the conventional warranty. A bid evaluation model is also developed for the warranty option approach. 相似文献
5.
Cinkilic Emre Moodispaw Michael Zhang Jianyue Miao Jiashi Luo Alan A. 《Metallurgical and Materials Transactions A》2022,53(8):2861-2873
Metallurgical and Materials Transactions A - The use of secondary aluminum for structural components in the automotive industry is limited by the high Fe contents in recycled alloys which often... 相似文献
6.
Atar Musa Keskin Hakan Güçlü Yavuzcan H. 《Journal of Coatings Technology and Research》2004,1(3):219-224
The impacts of impregnation and bleaching on the varnish layer hardness of Oriental beech (Fagus orientalist L.) wood were investigated. A number of bleaching combinations {[NaOH−H2O2], [NaOH−Ca(OH)2−H2O2], [NaOH−MgSO4−H2O2] [NaHSO3−H2C2O4], [NaSiO3−H2O2], [KMnO4+NaHSO3+H2O3]} were applied at 18% concentration for bleaching to both impregnated and unimpregnated specimens of Oriental beech wood.
Subsequently, water-based (WB) varnish was coated over the samples and the varnish layer hardness values were determined in
accordance with ASTM D 4366-95.
All of the chemicals used for bleaching reduced the surface hardness. However, after varnish coating, the hardness of most
samples was similar to that of the varnish-coated natural (control) samples. 相似文献
7.
Hiba Messaoudi Fayçal Djazi Mohamed Litim Bahadır Keskin Maamar Slimane Djillali Bekhiti 《Journal of Adhesion Science and Technology》2020,34(20):2216-2244
AbstractCorrosion inhibitors based on environmentally friendly and harmless products are currently being studied and developed. The corrosion inhibition properties of caffeine (1,3,7-trimethylxanthine) on copper corrosion in aqueous chloride solution (3.5?wt.% NaCl) are analysed here using stationary and transient electrochemical methods, and a theoretical study based on density functional theory is carried out. Caffeine is a very competitive compared to the chemical inhibitors that are often used for copper protection. Electrochemical and impedance experiments reveal that the protective efficiency of caffeine reaches a value of 96% at a concentration of 10?2?mol L?1. Based on these results, the Langmuir model appears to be the best representation of the adsorption of caffeine onto the copper surface. Scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and X-ray diffraction (XRD) were used to determine the surface morphology and the chemical composition of the copper surface in chloride media, in the absence and presence of caffeine. The results show the development of a mechanism of corrosion inhibition. In order to confirm the correlation between the inhibitory effect and the molecular structure of caffeine, quantum chemical parameters are used to calculate its electronic properties. 相似文献
8.
Hamed Salimkhani Emre Erdem Selmiye Alkan Gursel Alp Yurum 《Journal of the American Ceramic Society》2021,104(8):4257-4271
Recently, lanthanides have been employed by researchers to examine their impact on the structure and properties of Li7La3Zr2O12 (LLZO) garnets. In this regard, we developed Europium oxide (Eu2O3) doped LLZO (Li7+δEuxLa3−δZr2−δO12−δ) solid electrolyte which demonstrates a cubic phase with the symmetry of Iad (No.230) at room temperature. In this investigation, different concentrations of Eu ranging from 0.1 to 0.6 atoms per formula unit (pfu) were doped into Li7La3Zr2O12 to evaluate the impact of Eu on the stability of the cubic phase and thereby the ionic conductivity. The results unveiled that upon doping Eu3+ ions, the Eu2+ state is also formed and is then self-doped into the structure in which Rietveld refinement coupled with XPS, EPR, and solid-state NMR suggests that Eu3+ ions most probably partially occupy Zr4+ (16a) site, the Eu2+ ions occupy La3+ (24d) site, and the Li+ ions occupy two different sites (24d and 96h). It was further found that such a site preference induces distortion at LaO8 polyhedrons opening up the neck for Li-ions diffusion, thereby enhancing the ionic conductivity. Moreover, it was revealed that Li-ions probably hop from 96h to 24d and then to 96h site to generate the Li-ion movement. Overall, by introducing Eu ions into the LLZO structure, an enhanced bulk ionic conductivity of 0.30 × 10−3 S/cm at 298 K with a minimum electronic conductivity of 2.547 × 10−9 S/cm at 298 K was achieved. 相似文献
9.
Emre Akyurek Alexandre Dilly Fabrice Jourdan Zhu Liu Souraneel Chattoraj Itziar Berruezo Juandeaburre Michel Heinrich Leonid Paramonov Peter Turner Stelarc Tatiana Kalganova 《计算机技术与应用:英文》2013,(11):569-574
In the development of robotic limbs, the side of members is of importance to define the shape of artificial limbs and the range of movements. It is mainly significant tbr biomedical applications concerning patients suffering arms or legs injuries, fn this paper, the concept of an ambidextrous design lbr robot hands is introduced. The fingers can curl in one xvay or another, to imitate either a right hand or a left hand. The advantages and inconveniences of different models have been investigated to optimise the range and the maximum force applied by fingers. Besides, a remote control interthce is integrated to the system, allowing both to send comrnands through internet and to display a video streaming of the ambidextrous hand as feedback. Therefore, a robotic prosthesis could be used for the first time in telerehabilitation. The main application areas targeted are physiotherapy alter strokes or management of phantom pains/br amputees by/earning to control the ambidextrous hand. A client application is also accessible on Facehook social network, making the robotic limb easily reachable for the patients. Additionally the ambidextrous hand can be used tbr robotics research as well as artistic performances. 相似文献
10.
For robustness analysis with integral quadratic constraints, we formulate a new positivity condition on the solution of the corresponding linear matrix inequality which is necessary and sufficient for nominal stability of the underlying system. The application of this technical result is illustrated by a complete solution of the L2-gain and robust H2-estimator design problems if the uncertainties are characterized by dynamic integral quadratic constraints. 相似文献