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排序方式: 共有303条查询结果,搜索用时 15 毫秒
1.
Jennie O'Loughlin Silvia Napolitano Fahad Alkhathami Cillian O'Beirne Daniel Marhöfer Megan O'Shaughnessy Prof. Orla Howe Prof. Matthias Tacke Dr. Marina Rubini 《Chembiochem : a European journal of chemical biology》2021,22(6):1093-1098
Antibiotic resistance is a growing problem for public health and associated with increasing economic costs and mortality rates. Silver and silver-related compounds have been used for centuries due to their antimicrobial properties. In this work, we show that 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene silver(I) acetate/NHC*-Ag-OAc (SBC3) is a reversible, high affinity inhibitor of E. coli thioredoxin reductase (TrxR; Ki=10.8±1.2 nM). Minimal inhibition concentration (MIC) tests with different E. coli and P. aeruginosa strains demonstrated that SBC3 can efficiently inhibit bacterial cell growth, especially in combination with established antibiotics like gentamicin. Our results show that SBC3 is a promising antibiotic drug candidate targeting bacterial TrxR. 相似文献
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Rizwan Ullah Khan Haojie Yu Li Wang Lisong Teng Zain-ul-Abdin Ahsan Nazir Shah Fahad Tarig Elshaarani Fazal Haq Di Shen 《应用聚合物科学杂志》2020,137(46):49424
The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on-demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by 1H NMR, 31P NMR, FT-IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug-loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs-based nanoparticles may find their application as effective drug carriers for cancer therapy. 相似文献
5.
This paper presents a method of transferring voice using short messaging service in satellite communication system. The method is especially applicable in a situation where signal strength is low and voice call is not possible. In a tunnel, basement or environment with bad climate conditions, signal strength usually gets weak which make voice call difficult but SMS works in such situation. An application has been developed using J2ME language in order to test the proposed method. For experimentation, Thuraya SG-2520 satellite phone has been used. 相似文献
6.
Fahad Shahbaz Khan Shida Beigpour Joost van de Weijer Michael Felsberg 《Machine Vision and Applications》2014,25(6):1385-1397
Computer analysis of visual art, especially paintings, is an interesting cross-disciplinary research domain. Most of the research in the analysis of paintings involve medium to small range datasets with own specific settings. Interestingly, significant progress has been made in the field of object and scene recognition lately. A key factor in this success is the introduction and availability of benchmark datasets for evaluation. Surprisingly, such a benchmark setup is still missing in the area of computational painting categorization. In this work, we propose a novel large scale dataset of digital paintings. The dataset consists of paintings from 91 different painters. We further show three applications of our dataset namely: artist categorization, style classification and saliency detection. We investigate how local and global features popular in image classification perform for the tasks of artist and style categorization. For both categorization tasks, our experimental results suggest that combining multiple features significantly improves the final performance. We show that state-of-the-art computer vision methods can correctly classify 50 % of unseen paintings to its painter in a large dataset and correctly attribute its artistic style in over 60 % of the cases. Additionally, we explore the task of saliency detection on paintings and show experimental findings using state-of-the-art saliency estimation algorithms. 相似文献
7.
Adaptive interpolation scheme for NURBS curves with the integration of machining dynamics 总被引:13,自引:4,他引:13
Xianbing Liu Fahad Ahmad Kazuo Yamazaki Masahiko Mori 《International Journal of Machine Tools and Manufacture》2005,45(4-5):433-444
This paper develops a comprehensive interpolation scheme for non-uniform rational B-spline (NURBS) curves, which does not only simultaneously meet the requirements of both constant feedrate and chord accuracy, but also real-time integrates machining dynamics in the interpolation stage. Although the existing work in this regard has realized the importance to simultaneously consider chord error and machining dynamics, none has really incorporated these in one complete interpolation scheme. In this paper, machining dynamics is considered for three aspects: sharp corners or feedrate sensitive corners on the curves, components with high frequencies or frequencies matching machine natural ones and high jerks. A look-ahead module was developed for detecting and adaptively adjusting the feedrate at the sharp corners. By Fast Fourier Transform (FFT) analysis with a moving window in the interpolation stage identified were some special frequency components such as those containing high frequencies or with frequencies matching machine natural ones. Then, the notch filtering or time spacing method was used to eliminate these components. To more completely reduce feedrate and acceleration fluctuations, the jerk-limited algorithm was also developed. Finally, the interpolated feedrate was further smoothened with B-spline fitting method and the NURBS curves were re-interpolated with the smoothened feedrate. During the interpolation, the chord error was repeatedly checked and confined in the prescribed tolerance. Two NURBS curves were used as examples to test the feasibility of the developed interpolation scheme. 相似文献
8.
Adil Fahad Zahir Tari Ibrahim Khalil Ibrahim Habib Hussein Alnuweiri 《Computer Networks》2013,57(9):2040-2057
There is significant interest in the network management and industrial security community about the need to identify the “best” and most relevant features for network traffic in order to properly characterize user behaviour and predict future traffic. The ability to eliminate redundant features is an important Machine Learning (ML) task because it helps to identify the best features in order to improve the classification accuracy as well as to reduce the computational complexity related to the construction of the classifier. In practice, feature selection (FS) techniques can be used as a preprocessing step to eliminate irrelevant features and as a knowledge discovery tool to reveal the “best” features in many soft computing applications. In this paper, we investigate the advantages and disadvantages of such FS techniques with new proposed metrics (namely goodness, stability and similarity). We continue our efforts toward developing an integrated FS technique that is built on the key strengths of existing FS techniques. A novel way is proposed to identify efficiently and accurately the “best” features by first combining the results of some well-known FS techniques to find consistent features, and then use the proposed concept of support to select a smallest set of features and cover data optimality. The empirical study over ten high-dimensional network traffic data sets demonstrates significant gain in accuracy and improved run-time performance of a classifier compared to individual results produced by some well-known FS techniques. 相似文献
9.
Razzaq Saad Shah Babar Iqbal Farkhund Ilyas Muhammad Maqbool Fahad Rocha Alvaro 《Neural computing & applications》2023,35(11):8017-8026
Neural Computing and Applications - A lot of different methods are being opted for improving the educational standards through monitoring of the classrooms. The developed world uses Smart... 相似文献
10.
Faisal Bahadur Arif Iqbal Umar Insaf Ullah Fahad Algarni Muhammad Asghar Khan 《计算机系统科学与工程》2022,42(2):589-604
Scalability is one of the most important quality attribute of software-intensive systems, because it maintains an effective performance parallel to the large fluctuating and sometimes unpredictable workload. In order to achieve scalability, thread pool system (TPS) (which is also known as executor service) has been used extensively as a middleware service in software-intensive systems. TPS optimization is a challenging problem that determines the optimal size of thread pool dynamically on runtime. In case of distributed-TPS (DTPS), another issue is the load balancing b/w available set of TPSs running at backend servers. Existing DTPSs are overloaded either due to an inappropriate TPS optimization strategy at backend servers or improper load balancing scheme that cannot quickly recover an overload. Consequently, the performance of software-intensive system is suffered. Thus, in this paper, we propose a new DTPS that follows the collaborative round robin load balancing that has the effect of a double-edge sword. On the one hand, it effectively performs the load balancing (in case of overload situation) among available TPSs by a fast overload recovery procedure that decelerates the load on the overloaded TPSs up to their capacities and shifts the remaining load towards other gracefully running TPSs. And on the other hand, its robust load deceleration technique which is applied to an overloaded TPS sets an appropriate upper bound of thread pool size, because the pool size in each TPS is kept equal to the request rate on it, hence dynamically optimizes TPS. We evaluated the results of the proposed system against state of the art DTPSs by a client-server based simulator and found that our system outperformed by sustaining smaller response times. 相似文献